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Ins1 [extracellular region]
Stable Identifier
R-MMU-74673
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
2xHC-INS(25-54), P01325
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Peptide hormone metabolism (Mus musculus)
Synthesis, secretion, and deacylation of Ghrelin (Mus musculus)
Acyl Ghrelin and C-Ghrelin are secreted (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Autophosphorylation of insulin receptor (Mus musculus)
Insulin:Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin binds the insulin receptor (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
Binding of SHC1 to insulin receptor (Mus musculus)
GRB10:INSR [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
IRS activation (Mus musculus)
Binding of IRS to insulin receptor (Mus musculus)
GRB10:INSR [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Dissociation of IRS-P from insulin receptor (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Phosphorylation of IRS (Mus musculus)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Phosphorylation of SHC1 (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Signal attenuation (Mus musculus)
Binding of Grb10 to the insulin receptor (Mus musculus)
GRB10:INSR [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
Internalisation of the insulin receptor (Mus musculus)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
Insulin [extracellular region] (Mus musculus)
Ins1 [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P01325 Ins1
Gene Names
Ins1, Ins-1
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-85, peptide:88-108
Reference Genes
BioGPS Gene:16333 Ins1
CTD Gene:16333 Ins1
ENSEMBL:ENSMUSG00000035804.6 Ins1
KEGG Gene (Mus musculus):16333 Ins1
Monarch:16333 Ins1
NCBI Gene:16333 Ins1
UCSC:P01325 Ins1
Reference Transcript
RefSeq:NM_008386.4 Ins1
Other Identifiers
10463906
1422447_at
16333
165489_f_at
17360301
4432096
4631506
5097014
5434024
97658_f_at
97659_r_at
A_51_P312755
A_55_P1959318
GE118032
GO:0000278
GO:0001819
GO:0002020
GO:0002376
GO:0002674
GO:0003013
GO:0005158
GO:0005159
GO:0005179
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005829
GO:0005975
GO:0006006
GO:0006091
GO:0006520
GO:0006521
GO:0006629
GO:0006953
GO:0006954
GO:0007186
GO:0008284
GO:0008286
GO:0010033
GO:0010628
GO:0010629
GO:0010750
GO:0016192
GO:0023052
GO:0030154
GO:0030163
GO:0030297
GO:0030312
GO:0031012
GO:0031410
GO:0031623
GO:0032880
GO:0034097
GO:0034330
GO:0034774
GO:0038060
GO:0042060
GO:0042177
GO:0042311
GO:0042593
GO:0042802
GO:0043226
GO:0043410
GO:0043434
GO:0045725
GO:0045818
GO:0045821
GO:0045840
GO:0045861
GO:0045922
GO:0046326
GO:0046628
GO:0046631
GO:0048018
GO:0048856
GO:0050708
GO:0050709
GO:0050714
GO:0050995
GO:0051247
GO:0051591
GO:0051897
GO:0055085
GO:0055086
GO:0055089
GO:0060266
GO:0060267
GO:0062023
GO:0071333
GO:0072659
GO:0098542
GO:0098772
GO:0140014
GO:1900182
GO:1901135
GO:1901701
GO:1902952
GO:1903076
GO:1903427
GO:1904659
GO:1990535
GO:2000252
ILMN_2743236
Msa.2390.0_at
mMC008335
Participates
as a component of
Insulin [extracellular region] (Mus musculus)
Other forms of this molecule
6xHC-Ins1(25-108) [secretory granule lumen]
Ins1 [Golgi lumen]
Ins1 [secretory granule lumen]
Ins1 [endoplasmic reticulum lumen]
Ins1(57-85) [extracellular region]
Ins1(57-85) [secretory granule lumen]
Ins1 [extracellular region]
Ins1 [endosome lumen]
Ins1 [endosome lumen]
Ins1 [Golgi membrane]
Ins1 [transport vesicle]
Ins1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Ins1 [endoplasmic reticulum lumen]
Ins1(25-108) [endoplasmic reticulum lumen]
6xHC-Ins1(88-108) [extracellular region]
2xHC-Ins1(25-54) [extracellular region]
Ins1 [cytosol]
6xHC-Ins1(88-108) [secretory granule lumen]
2xHC-Ins1(25-54) [secretory granule lumen]
Inferred From
2xHC-INS(25-54) [extracellular region]
(Homo sapiens)
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 31 and 96 (in Homo sapiens)
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 43 and 109 (in Homo sapiens)
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_032412.3
Ensembl
ENSMUST00000039652
,
ENSMUSG00000035804
,
ENSMUSP00000049095
PRO
P01325
MGI
96572
PDB
3WS3
,
7QHP
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