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INS [extracellular region]
Stable Identifier
R-SSC-74673
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
2xHC-INS(25-54), P01315
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Sus scrofa)
Peptide hormone metabolism (Sus scrofa)
Synthesis, secretion, and deacylation of Ghrelin (Sus scrofa)
Acyl Ghrelin and C-Ghrelin are secreted (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Sus scrofa)
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by Insulin receptor (Sus scrofa)
Autophosphorylation of insulin receptor (Sus scrofa)
Insulin:Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin binds the insulin receptor (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin receptor signalling cascade (Sus scrofa)
Binding of SHC1 to insulin receptor (Sus scrofa)
GRB10:INSR [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
IRS activation (Sus scrofa)
Binding of IRS to insulin receptor (Sus scrofa)
GRB10:INSR [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Dissociation of IRS-P from insulin receptor (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Phosphorylation of IRS (Sus scrofa)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Phosphorylation of SHC1 (Sus scrofa)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Signal attenuation (Sus scrofa)
Binding of Grb10 to the insulin receptor (Sus scrofa)
GRB10:INSR [plasma membrane] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
Internalisation of the insulin receptor (Sus scrofa)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
Insulin [extracellular region] (Sus scrofa)
INS [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:P01315
Gene Names
INS
Reference Genes
BioGPS Gene:397415 INS
ENSEMBL:ENSSSCG00000033740.1 INS
ENSEMBL:ENSSSCG00015004005.1 INS
ENSEMBL:ENSSSCG00025023773.1 INS
ENSEMBL:ENSSSCG00030073948.1 INS
ENSEMBL:ENSSSCG00035019667.1 INS
ENSEMBL:ENSSSCG00040017207.1 INS
ENSEMBL:ENSSSCG00045005189.1 INS
ENSEMBL:ENSSSCG00050008342.1 INS
ENSEMBL:ENSSSCG00055016292.1
ENSEMBL:ENSSSCG00060035069.1 INS
ENSEMBL:ENSSSCG00065063887.1 INS
ENSEMBL:ENSSSCG00070015252.1 INS
KEGG Gene (Sus scrofa):397415 INS
Monarch:397415 INS
NCBI Gene:397415 INS
Reference Transcript
RefSeq:NM_001109772.1 INS
Other Identifiers
397415
GO:0000278
GO:0001819
GO:0002020
GO:0002376
GO:0002674
GO:0003013
GO:0005158
GO:0005159
GO:0005179
GO:0005576
GO:0005615
GO:0005975
GO:0006091
GO:0006520
GO:0006521
GO:0006629
GO:0006953
GO:0006954
GO:0007186
GO:0008284
GO:0008286
GO:0010628
GO:0010629
GO:0010750
GO:0023052
GO:0030154
GO:0030163
GO:0032880
GO:0034330
GO:0038060
GO:0042060
GO:0042177
GO:0042311
GO:0042593
GO:0042802
GO:0043410
GO:0045725
GO:0045818
GO:0045821
GO:0045840
GO:0045861
GO:0045922
GO:0046326
GO:0046628
GO:0046631
GO:0048018
GO:0048856
GO:0050708
GO:0050709
GO:0050995
GO:0051247
GO:0051897
GO:0055085
GO:0055086
GO:0055089
GO:0060266
GO:0060267
GO:0072659
GO:0098542
GO:0098772
GO:0140014
GO:1900182
GO:1901135
GO:1902952
GO:1903076
GO:1903427
GO:1990535
GO:2000252
Ssc.583.1.S1_at
Participates
as a component of
Insulin [extracellular region] (Sus scrofa)
Other forms of this molecule
INS [Golgi lumen]
INS [secretory granule lumen]
INS [endoplasmic reticulum lumen]
INS [endoplasmic reticulum lumen]
INS [endoplasmic reticulum-Golgi intermediate compartment membrane]
INS [transport vesicle]
INS [Golgi membrane]
INS [endosome lumen]
INS [endosome lumen]
INS [extracellular region]
Inferred From
2xHC-INS(25-54) [extracellular region]
(Homo sapiens)
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 31 and 96 (in Homo sapiens)
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 43 and 109 (in Homo sapiens)
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_001103242.1
OpenTargets
ENSG00000254647
Ensembl
ENSSSCT00000064136
,
ENSSSCP00000044635
,
ENSSSCG00000033740
VGNC
99778
PDB
1IZB
,
3T2A
,
1B2E
,
1MPJ
,
1IZA
,
1ZNI
,
4INS
,
3FHP
,
1B19
,
6INS
,
1WAV
,
1DEI
,
5D5E
,
1B18
,
5LIS
,
1B17
,
5FB6
,
3RTO
,
1M5A
,
2G4M
,
6Z7Z
,
3INS
,
1ZEI
,
2ZPP
,
1B2B
,
1B2A
,
1B2D
,
1B2F
,
1B2C
,
1B2G
,
3MTH
,
4A7E
,
1SDB
,
9INS
,
7INS
,
7AC4
,
3GKY
,
2EFA
,
5D52
,
5D53
,
2TCI
,
5D54
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01315
11
INS [Golgi lumen]
(R-SSC-264890)
INS [secretory granule lumen]
(R-SSC-264984)
INS [endoplasmic reticulum lumen]
(R-SSC-265075)
INS [endoplasmic reticulum lumen]
(R-SSC-264893)
INS [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-SSC-6807734)
INS [transport vesicle]
(R-SSC-6808712)
INS [Golgi membrane]
(R-SSC-6808710)
INS [endosome lumen]
(R-SSC-141720)
INS [endosome lumen]
(R-SSC-141723)
INS [extracellular region]
(R-SSC-74672)
INS [extracellular region]
(R-SSC-74673)
0.663
3
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