4xHC-INS(90-110) [extracellular region]

Stable Identifier
R-HSA-74672
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
insulin A chain
Icon
4xHC-INS(90-110) [extracellular region] icon
4xHC-INS(90-110) [extracellular region] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
BioGPS Gene:3630 INS
COSMIC (genes):INS INS
CTD Gene:3630 INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
ENSEMBL:ENSG00000254647.7 INS
HGNC:6081 INS
KEGG Gene (Homo sapiens):3630 INS
Monarch:3630 INS
NCBI Gene:3630 INS
OMIM:176730 INS
UCSC:P01308 INS
Reference Transcript
Other Identifiers
11741851_s_at
160038_s_at
206598_PM_at
206598_at
3359172
3359173
3359174
3359176
3359177
3359178
3359179
3630
A_23_P1981
GE59971
GO:0000139
GO:0000278
GO:0001819
GO:0002020
GO:0002376
GO:0002674
GO:0003013
GO:0005158
GO:0005159
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005975
GO:0006006
GO:0006091
GO:0006351
GO:0006355
GO:0006520
GO:0006521
GO:0006629
GO:0006953
GO:0006954
GO:0007165
GO:0007186
GO:0007267
GO:0008284
GO:0008286
GO:0010628
GO:0010629
GO:0010750
GO:0012501
GO:0014068
GO:0022898
GO:0023052
GO:0030133
GO:0030154
GO:0030163
GO:0030307
GO:0030335
GO:0031410
GO:0031904
GO:0031954
GO:0032148
GO:0032880
GO:0033116
GO:0033861
GO:0034330
GO:0034774
GO:0036211
GO:0038060
GO:0042060
GO:0042177
GO:0042311
GO:0042593
GO:0042802
GO:0043226
GO:0043410
GO:0045597
GO:0045721
GO:0045725
GO:0045818
GO:0045821
GO:0045840
GO:0045861
GO:0045922
GO:0046326
GO:0046628
GO:0046631
GO:0046889
GO:0048018
GO:0048167
GO:0048856
GO:0048870
GO:0050708
GO:0050709
GO:0050714
GO:0050877
GO:0050890
GO:0050995
GO:0051000
GO:0051092
GO:0051247
GO:0051897
GO:0055085
GO:0055086
GO:0055089
GO:0060266
GO:0060267
GO:0072659
GO:0090277
GO:0090336
GO:0098542
GO:0098772
GO:0140014
GO:1900182
GO:1900273
GO:1901135
GO:1902176
GO:1902952
GO:1903076
GO:1903427
GO:1990535
GO:2000252
HMNXSV003049612
ILMN_1666966
J00268_s_at
PH_hs_0005022
PH_hs_0031401
V00565_s_at
g4557670_3p_at
Participates
as a component of
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
C Peptide [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
6xHC-INS(25-110) [Golgi membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
INS(90-110) [endosome lumen]
INS(25-54) [endosome lumen]
2xHC-INS(25-54) [extracellular region]
Inferred To
INS [extracellular region] (Bos taurus)
INS [extracellular region] (Canis familiaris)
INS [extracellular region] (Gallus gallus)
INS [extracellular region] (Sus scrofa)
Ins2 [extracellular region] (Mus musculus)
Ins2 [extracellular region] (Rattus norvegicus)
ins [extracellular region] (Danio rerio)
fbxw8 [extracellular region] (Xenopus tropicalis)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 95 and 100
Coordinate
95
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 109 and 43
Coordinate
109
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 96 and 31
Coordinate
96
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
OpenTargets
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
1RWE, 5MT3, 6VET, 1KMF, 4UNE, 6S4J, 7SL7, 1XDA, 1HIS, 7JP3, 6SOF, 1AIY, 2KXK, 6JK8, 4GBC, 2MLI, 6Z7Y, 7NMG, 2OMH, 3P33, 8GUY, 3BXQ, 4EY1, 5CO9, 2HIU, 5USV, 1EVR, 1OS4, 4UNH, 3ROV, 2N2X, 7PG2, 2AIY, 1XGL, 4FG3, 4EYN, 1TYL, 5MWQ, 7KD6, 1ZEG, 1SJT, 2CEU, 7QGF, 2WRU, 4AJX, 1FUB, 6X4X, 4IYF, 1BEN, 3IR0, 5BOQ, 7SL1, 4F0O, 4Z78, 2KJU, 7RZE, 2L1Y, 5URT, 2WS1, 2OMI, 2H67, 2L1Z, 4GBN, 7SL3, 4EWZ, 3E7Y, 3UTT, 4F1C, 4F4T, 5C0D, 2QIU, 7BWA, 5CNY, 1JCO, 6TYH, 2KJJ, 5UDP, 5MT9, 6CE9, 2JV1, 2WS4, 1AI0, 6HN5, 5UOZ, 4GBI, 3W7Z, 1EV6, 8EYY, 2WS6, 5HPU, 5WOB, 4EY9, 1T1P, 1J73, 1G7B, 1T0C, 2OLZ, 6Z7W, 6GV0, 4CXL, 6O17, 1QIZ, 1MSO, 2C8R, 2JZQ, 7Z5L, 7SL4, 1IOH, 3TT8, 2M1D, 3ZI3, 2M2O, 5HYJ, 4F8F, 2JUU, 2M1E, 6B70, 3FQ9, 4F1A, 2R36, 5HPR, 5CJO, 4XC4, 4EYP, 6TC2, 4IUZ, 3AIY, 4EFX, 4F1D, 5EMS, 7STJ, 3ZQR, 1SF1, 3W11, 1JK8, 4EX0, 1T1Q, 4CXN, 2WRV, 4AJZ, 6VEP, 3UTQ, 2MPG, 3P2X, 3E7Z, 4Y19, 4UNG, 1LKQ, 4CY7, 5MHD, 5URU, 7MD5, 2WRW, 1OS3, 3V1G, 7PG0, 5BPO, 2VJZ, 5AIY, 5MAM, 5BQQ, 7MQR, 4AKJ, 7SL2, 3EXX, 2HHO, 1HUI, 7NHU, 2WS7, 1SJU, 6S34, 6VES, 3I3Z, 3W7Y, 1ZEH, 1HIQ, 5USP, 1B9E, 5UU3, 5CO2, 1JCA, 1EV3, 7RZF, 7SL6, 1XW7, 7V3P, 2OMG, 4NIB, 2N2W, 1G7A, 4EYD, 3U4N, 3W13, 2MPI, 2M2M, 4Z76, 2JMN, 4OGA, 2KQQ, 6NWV, 5UQA, 2R34, 2W44, 4F1B, 1EFE, 6CE7, 7MD4, 8GSG, 7RKD, 1MHJ, 1Q4V, 5EN9, 2OM1, 1TYM, 7STK, 3W80, 4FKA, 7YQ3, 3Q6E, 2LGB, 5T7R, 3ILG, 5UU2, 4F1F, 7RZI, 4F4V, 6U46, 1HLS, 2LWZ, 4Y1A, 2WBY, 3UTS, 7U6E, 2C8Q, 4EWW, 4GBK, 4WDI, 7PG4, 6BFC, 4AK0, 6H3M, 2M2N, 7MQS, 5WDM, 1FU2, 2WRX, 1VKT, 5HQI, 4EX1, 1QIY, 5WBT, 5ENA, 3ZS2, 2JUM, 6CEB, 7MQO, 1HIT, 5USS, 2R35, 2G54, 7QID, 3KQ6, 1MHI, 5CO6, 4RXW, 6CK2, 3JSD, 4F1G, 5VIZ, 2RN5, 1T1K, 3INC, 6VER, 6P4Z, 6S4I, 2WC0, 2K91, 2MVC, 1UZ9, 8EYX, 7STI, 1W8P, 2N2V, 3V19, 2OLY, 4EXX, 1K3M, 3ZU1, 7YQ5, 6GNQ, 1IOG, 1GUJ, 2OMQ, 7STH, 2M2P, 4P65, 2VK0, 2G56, 5UU4, 5HRQ, 7YQ4, 2K9R, 4IYD, 3I40, 8EZ0, 3HYD, 2JUV, 7BW8, 1LPH, 4F51, 1HTV, 7BW7, 7Z5Q, 7S4Y, 2HH4, 4GBL, 3W12, 4EWX, 4F0N, 7PG3, 1A7F, 2MVD, 5BTS, 6K59, 1TRZ, 5E7W, 1ZNJ, 6JR3, 1QJ0, 4AIY, 2KQP, 6B3Q, 2OM0, 2WS0, 4Z77
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01308 INS  20 0.971 21
 UniProt:P06213-2 INSR      0.697 6
 UniProt:P14735-1 IDE      0.618 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:P0DPK4 NT2NC      0.556 3
 UniProt:Q8IUG1 KRTAP1-3  1 0.556 3
 UniProt:Q07627 KRTAP1-1  1 0.556 3
 UniProt:A8MQ03 CRTP1      0.556 3
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