Reactome | Intra-Golgi traffic

Intra-Golgi traffic

Stable Identifier

R-HSA-6811438

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

The mammalian Golgi consists of at least three biochemically distinct cisternae, cis-, medial- and trans (reviewed in Szul and Sztul, 2011; Day et al, 2013). The structure and function of the Golgi are tightly interconnected, such that proteins that are required for protein transport through the Golgi are often also required for the organization of the Golgi stacks, and vice versa (reviewed in Liu and Storrie, 2012; Liu and Storrie, 2015; Chia and Gleeson, 2014; Munro, 2011). Newly synthesized proteins from the ER and ERGIC are received at the cis face of the Golgi and flow through to the trans-Golgi before being released to the trans-Golgi network (TGN) for further secretion to the endolysosomal system, plasma membrane or extracellular region. Retrograde flow from the trans- to cis-cisternae moves endocytosed cargo from the extracellular region, the plasma membrane and the endolysosomal system back towards the ER. Intra-Golgi retrograde traffic also returns resident Golgi proteins to their appropriate cisternae, in this way facilitating cisternal remodeling or maturation (reviewed in Boncompain and Perez, 2013; Day et al, 2013). Intra-Golgi traffic in both directions is mediated by COPI carriers, with specificity of transport being determined at least in part by the complement of SNAREs, RABs and tethering proteins involved (reviewed in Szul and Sztul, 2011; Spang 2013; Willet et al, 2013; Chia and Gleeson, 2014).

Literature References

PubMed ID	Title	Journal	Year
22013193	COPII and COPI traffic at the ER-Golgi interface Szul, T, Sztul, E	Physiology (Bethesda)	2011
23846822	The many routes of Golgi-dependent trafficking Boncompain, G, Perez, F	Histochem. Cell Biol.	2013
25343031	Membrane tethering Chia, PZ, Gleeson, PA	F1000Prime Rep	2014
25708460	How Rab proteins determine Golgi structure Liu, S, Storrie, B	Int Rev Cell Mol Biol	2015
23881164	A three-stage model of Golgi structure and function Day, KJ, Staehelin, LA, Glick, BS	Histochem. Cell Biol.	2013
23732476	Retrograde traffic from the Golgi to the endoplasmic reticulum Spang, A	Cold Spring Harb Perspect Biol	2013
22581368	Are Rab proteins the link between Golgi organization and membrane trafficking? Liu, S, Storrie, B	Cell. Mol. Life Sci.	2012
21436057	The golgin coiled-coil proteins of the Golgi apparatus Munro, S	Cold Spring Harb Perspect Biol	2011
23839779	The Golgi puppet master: COG complex at center stage of membrane trafficking interactions Willett, R, Ungar, D, Lupashin, V	Histochem. Cell Biol.	2013