ARF1:GTP binds Golgin TRIP11

Stable Identifier
Reaction [binding]
Homo sapiens
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TRIP11, also known as GMAP210, is a cis-Golgi localized coiled coil Golgin with roles in anterograde and retrograde intra-Golgi trafficking (Infante et al, 1999; Pernet-Gallay et al, 2002). TRIP11 has an N-terminal amphipathic lipid packing sensor (ALPS) domain which binds preferentially to highly curved membranes such as those on veiscles, and a GRIP-related ARF binding (GRAB) domain at its C-terminus that binds to ARF1:GTP. This asymmetric binding allows TRIP11 to tether vesicles to the Golgi membrane. This asymmetric binding of TRIP11 is maintained in part by the fact that ARFGAP1 also contains an ALPS domain and therefore stimulates the GTPase activity of any ARF1:GTP that is present in the vesicular membrane (Drin et al, 2008; Cardenas et al, 2009; Gillingham et al, 2004).

Literature References
PubMed ID Title Journal Year
10189370 GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein

Infante, C, Ramos-Morales, F, Fedriani, C, Rios, RM, Bornens, M

J. Cell Biol. 1999
12383348 The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus

Johannes, L, Pernet-Gallay, K, Rios, RM, Goud, B, Bornens, M, Antony, C

Traffic 2002
15504911 The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi

Boone, C, Tong, AH, Gillingham, AK, Munro, S

J. Cell Biol. 2004
18451304 Asymmetric tethering of flat and curved lipid membranes by a golgin

Gounon, P, Morello, V, Drin, G, Casella, JF, Antonny, B

Science 2008
19715559 Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms

Rios, RM, Goud, B, Bornens, M, Rivero, S, Cardenas, J

BMC Biol. 2009
Orthologous Events
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