Reactome | ARF1:GTP binds Golgin TRIP11

ARF1:GTP binds Golgin TRIP11

Stable Identifier

R-HSA-8847875

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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TRIP11, also known as GMAP210, is a cis-Golgi localized coiled coil Golgin with roles in anterograde and retrograde intra-Golgi trafficking (Infante et al, 1999; Pernet-Gallay et al, 2002). TRIP11 has an N-terminal amphipathic lipid packing sensor (ALPS) domain which binds preferentially to highly curved membranes such as those on veiscles, and a GRIP-related ARF binding (GRAB) domain at its C-terminus that binds to ARF1:GTP. This asymmetric binding allows TRIP11 to tether vesicles to the Golgi membrane. This asymmetric binding of TRIP11 is maintained in part by the fact that ARFGAP1 also contains an ALPS domain and therefore stimulates the GTPase activity of any ARF1:GTP that is present in the vesicular membrane (Drin et al, 2008; Cardenas et al, 2009; Gillingham et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
10189370	GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein Infante, C, Ramos-Morales, F, Fedriani, C, Rios, RM, Bornens, M	J. Cell Biol.	1999
12383348	The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus Johannes, L, Pernet-Gallay, K, Rios, RM, Goud, B, Bornens, M, Antony, C	Traffic	2002
15504911	The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi Boone, C, Tong, AH, Gillingham, AK, Munro, S	J. Cell Biol.	2004
18451304	Asymmetric tethering of flat and curved lipid membranes by a golgin Gounon, P, Morello, V, Drin, G, Casella, JF, Antonny, B	Science	2008
19715559	Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms Rios, RM, Goud, B, Bornens, M, Rivero, S, Cardenas, J	BMC Biol.	2009