Reactome | CYTH proteins bind ARF1:GTP

CYTH proteins bind ARF1:GTP

Stable Identifier

R-HSA-8847880

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytohesin (CYTH) proteins 1, 2, 3 and 4 are ARF guanine nucleotide exchange factors (GEFs) for ARF1 as well as other ARFs. Recruitment to the membrane is mediated by direct interaction with ARF1:GTP as well as an interaction between the CYTH plexstrin homology (PH) domain and the lipid membrane (Chardin et al, 1996; Betz et al, 1998; Mossessova et al, 1998; Cherfils et al, 1998; Franco et al, 1998; Osagawara et al, 2000; Malaby et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
8945478	A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains Chardin, P, Jackson, CL, Béraud-Dufour, S, Paris, S, Robineau, S, Chabre, M, Antonny, B	Nature	1996
23940353	Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors Lambright, DG, van den Berg, B, Malaby, AW	Proc. Natl. Acad. Sci. U.S.A.	2013
10652308	Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors Togawa, A, Kirby, M, Vaughan, M, Ogasawara, M, Kim, SC, Adamik, R, Moss, J, Takeda, K, Ferrans, VJ	J. Biol. Chem.	2000
9476900	Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase Goldberg, J, Gulbis, JM, Mossessova, E	Cell	1998
9653114	Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1 Meadows, RP, Schnuchel, A, Wang, H, Fesik, SW, Harris, EA, Lipsky, BP, Olejniczak, ET, Betz, SF, Staunton, DE	Proc. Natl. Acad. Sci. U.S.A.	1998
9707577	ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function Chardin, P, Robineau, S, Goud, B, Monier, S, Boretto, J, Chavrier, P, Franco, M	Proc. Natl. Acad. Sci. U.S.A.	1998
9510256	Structure of the Sec7 domain of the Arf exchange factor ARNO Chardin, P, Béraud-Dufour, S, Robineau, S, Cherfils, J, Antonny, B, Ménétrey, J, Mathieu, M, Le Bras, G	Nature	1998