CYTH proteins bind ARF1:GTP

Stable Identifier
Reaction [binding]
Homo sapiens
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Cytohesin (CYTH) proteins 1, 2, 3 and 4 are ARF guanine nucleotide exchange factors (GEFs) for ARF1 as well as other ARFs. Recruitment to the membrane is mediated by direct interaction with ARF1:GTP as well as an interaction between the CYTH plexstrin homology (PH) domain and the lipid membrane (Chardin et al, 1996; Betz et al, 1998; Mossessova et al, 1998; Cherfils et al, 1998; Franco et al, 1998; Osagawara et al, 2000; Malaby et al, 2013).

Literature References
PubMed ID Title Journal Year
23940353 Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors

Malaby, AW, van den Berg, B, Lambright, DG

Proc. Natl. Acad. Sci. U.S.A. 2013
8945478 A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

Chardin, P, Paris, S, Antonny, B, Robineau, S, Béraud-Dufour, S, Jackson, CL, Chabre, M

Nature 1996
10652308 Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors

Ogasawara, M, Kim, SC, Adamik, R, Togawa, A, Ferrans, VJ, Takeda, K, Kirby, M, Moss, J, Vaughan, M

J. Biol. Chem. 2000
9476900 Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase

Mossessova, E, Gulbis, JM, Goldberg, J

Cell 1998
9653114 Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1

Betz, SF, Schnuchel, A, Wang, H, Olejniczak, ET, Meadows, RP, Lipsky, BP, Harris, EA, Staunton, DE, Fesik, SW

Proc. Natl. Acad. Sci. U.S.A. 1998
9707577 ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function

Franco, M, Boretto, J, Robineau, S, Monier, S, Goud, B, Chardin, P, Chavrier, P

Proc. Natl. Acad. Sci. U.S.A. 1998
9510256 Structure of the Sec7 domain of the Arf exchange factor ARNO

Cherfils, J, Ménétrey, J, Mathieu, M, Le Bras, G, Robineau, S, Béraud-Dufour, S, Antonny, B, Chardin, P

Nature 1998
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Orthologous Events
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