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NSF and SNAPs bind the cis-SNARE at the Golgi
Stable Identifier
R-HSA-8847637
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The cis-SNARE complex of STX5:PalmC-YKT6:BET1L:GOSR1 binds the NSF hexamer and alpha-SNAPs prior to the energy dependent disassembly for reuse (reviewed in Sudhof and Rothman, 2009; Hong and Lev, 2014).
Literature References
PubMed ID
Title
Journal
Year
24119662
Tethering the assembly of SNARE complexes
Hong, W
,
Lev, S
Trends Cell Biol.
2014
19164740
Membrane fusion: grappling with SNARE and SM proteins
Südhof, TC
,
Rothman, JE
Science
2009
Participants
Input
NSF hexamer [cytosol]
(Homo sapiens)
x 3
SNAPs [cytosol]
(Homo sapiens)
STX:PalmC-YKT6:BET1L:GOSR1 [Golgi membrane]
(Homo sapiens)
Output
STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane]
(Homo sapiens)
Participates
as an event of
Intra-Golgi traffic (Homo sapiens)
Orthologous Events
NSF and SNAPs bind the cis-SNARE at the Golgi (Bos taurus)
NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)
NSF and SNAPs bind the cis-SNARE at the Golgi (Canis familiaris)
NSF and SNAPs bind the cis-SNARE at the Golgi (Danio rerio)
NSF and SNAPs bind the cis-SNARE at the Golgi (Dictyostelium discoideum)
NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)
NSF and SNAPs bind the cis-SNARE at the Golgi (Gallus gallus)
NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)
NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)
NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)
NSF and SNAPs bind the cis-SNARE at the Golgi (Saccharomyces cerevisiae)
NSF and SNAPs bind the cis-SNARE at the Golgi (Schizosaccharomyces pombe)
NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)
Authored
Rothfels, K (2015-11-09)
Reviewed
Gillespie, ME (2016-02-02)
Created
Rothfels, K (2015-12-02)
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