Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/212)
Date Identifier Pathway Reference
2021-03-30 R-HSA-9725370 Signaling by ALK fusions and activated point mutants BibTex
2021-03-30 R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer BibTex
2021-03-30 R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling BibTex
2021-03-22 R-HSA-9700206 Signaling by ALK in cancer BibTex
2021-03-22 R-HSA-9700649 Drug resistance of ALK mutants BibTex
2021-03-22 R-HSA-9717323 ceritinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717326 crizotinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717329 lorlatinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717264 ASP-3026- resistant ALK mutants BibTex
2021-03-22 R-HSA-9717319 brigatinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717301 NVP-TAE684-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717316 alectinib resistant ALK mutants BibTex
2021-03-22 R-HSA-9700645 ALK mutants bind TKIs BibTex
2021-02-17 R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 BibTex
2020-11-06 R-HSA-9682385 FLT3 signaling in disease BibTex
Authored Reactions (15/1,281)
Date Identifier Reaction Reference
2021-05-03 R-RNO-201531 ALK dimerization BibTex
2021-03-30 R-HSA-9725338 NPM-ALK-dependent BCL2A1 gene expression BibTex
2021-03-30 R-HSA-9725357 NPM-ALK-dependent CEBPB gene expression BibTex
2021-03-30 R-HSA-9725342 NPM-ALK-dependent JUNB gene transcription BibTex
2021-03-30 R-HSA-9725345 NPM-ALK-dependent JUNB translation BibTex
2021-03-30 R-HSA-9725009 NPM-ALK translocates to the nucleus BibTex
2021-03-30 R-HSA-9725023 NPM-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 BibTex
2021-03-30 R-HSA-9725030 MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner BibTex
2021-03-30 R-HSA-9700200 PTPRZ dephosphorylates ligand-bound ALK dimers BibTex
2021-03-30 R-NUL-9700661 Active ALK binds Src BibTex
2021-03-30 R-HSA-9700648 Active ALK binds SRC BibTex
2021-03-30 R-NUL-9700655 Active ALK phosphorylates Src BibTex
2021-03-30 R-HSA-9700647 Active ALK phosphorylates SRC BibTex
2021-03-30 R-HSA-9725117 ALK gene expression BibTex
2021-03-30 R-HSA-9700149 Active ALK binds PLCG1 BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand BibTex
Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2017-02-22 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2017-02-22 R-HSA-9725885 P4 bind PGR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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