Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/165)
Date Identifier Pathway Reference
2020-04-22 R-HSA-9679509 Virion Assembly and Release BibTex
2020-04-01 R-HSA-9669938 Signaling by KIT in disease BibTex
2020-04-01 R-HSA-9669933 Signaling by kinase domain mutants of KIT BibTex
2020-04-01 R-HSA-9669935 Signaling by juxtamembrane domain KIT mutants BibTex
2020-04-01 R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants BibTex
2020-04-01 R-HSA-9669937 Drug resistance of KIT mutants BibTex
2020-04-01 R-HSA-9669917 Imatinib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669934 Sunitinib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669929 Regorafenib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669914 Dasatinib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669924 Masitinib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669926 Nilotinib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669936 Sorafenib-resistant KIT mutants BibTex
2020-04-01 R-HSA-9669921 KIT mutants bind TKIs BibTex
2020-03-24 R-HSA-9680187 Signaling by extracellular domain mutants of KIT BibTex
Authored Reactions (15/1,088)
Date Identifier Reaction Reference
2020-04-22 R-HSA-9686174 Accessory proteins are recruited to the maturing virion BibTex
2020-04-22 R-HSA-9685531 SARS virus buds into ERGIC lumen BibTex
2020-04-22 R-HSA-9685542 Viral release BibTex
2020-04-22 R-HSA-9684229 SUMO-p-N protein dimer binds genomic RNA BibTex
2020-04-22 R-HSA-9684234 Encapsidation of SARS coronavirus genomic RNA BibTex
2020-04-22 R-HSA-9684218 M protein oligomerization BibTex
2020-04-22 R-HSA-9684238 E and N are recruited to the M lattice BibTex
2020-04-22 R-HSA-9684241 Recruitment of Spike trimer to assembling virion BibTex
2020-04-01 R-HSA-9669893 KIT binds type I TKIs BibTex
2020-04-01 R-HSA-9680248 Phosphorylation of extracellular domain KIT mutants BibTex
2020-04-01 R-HSA-9670426 Disassociation and translocation of STATs to the nucleus downstream of KIT mutants BibTex
2020-04-01 R-HSA-9670428 KIT mutants bind GRB2-SOS BibTex
2020-04-01 R-HSA-9670436 p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS BibTex
2020-04-01 R-HSA-9670416 Recruitment of STATs by KIT mutants BibTex
2020-04-01 R-HSA-9670412 Phosphorylation of STATs downstream of KIT mutants BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) BibTex
Reviewed Reactions (12/12)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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