Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/250)
Date Identifier Pathway Reference
2025-01-06 R-HSA-9932444 ATP-dependent chromatin remodelers BibTex
2025-01-06 R-HSA-9932451 SWI/SNF chromatin remodelers BibTex
2025-01-06 R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex BibTex
2025-01-06 R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex BibTex
2025-01-06 R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) BibTex
2025-01-06 R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex BibTex
2025-01-06 R-HSA-9933937 Formation of the canonical BAF (cBAF) complex BibTex
2024-12-13 R-HSA-9931929 Defective GALM causes GALAC4 BibTex
2024-07-29 R-HSA-9865118 Diseases of branched-chain amino acid catabolism BibTex
2024-07-29 R-HSA-9915355 Beta-ketothiolase deficiency BibTex
2024-07-29 R-HSA-9865114 Maple Syrup Urine Disease BibTex
2024-07-29 R-HSA-9865113 Loss-of-function mutations in DBT cause MSUD2 BibTex
2024-07-29 R-HSA-9912529 H139Hfs13* PPM1K causes a mild variant of MSUD BibTex
2024-07-29 R-HSA-9907570 Loss-of-function mutations in DLD cause MSUD3/DLDD BibTex
2024-07-29 R-HSA-9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BibTex
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Authored Reactions (15/1,556)
Date Identifier Reaction Reference
2025-01-06 R-HSA-9932443 BICRA, BICRAL and BRD9 bind SMARCC dimer:SMARCDs BibTex
2025-01-06 R-HSA-9933236 SS18-containing ATPase complex binds SMARCC dimer:SMARCDs:BICRAs:BRD9 BibTex
2025-01-06 R-HSA-9934023 Formation of neural BAF (nBAF) BibTex
2025-01-06 R-HSA-9934021 Formation of neuronal progenitor BAF (npBAF) BibTex
2025-01-06 R-HSA-9934024 SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10 BibTex
2025-01-06 R-HSA-9934022 DPF2, PHF10 bind SMARCC1:SMARCC2 dimer:SMARD1:ARID1A BibTex
2025-01-06 R-HSA-9934028 ARID1A binds SMARCC1:SMARCC2 dimer:SMARCD1:SMARCE1:SMARCB1 BibTex
2025-01-06 R-HSA-9934026 SMARCE1 and SMARCB1 bind SMARCC1:SMARCC2 dimer:SMARCD1 BibTex
2025-01-06 R-HSA-9934027 SMARCC1 and SMARCC2 bind SMARCD1 BibTex
2025-01-06 R-MMU-9934111 Formation of neural BAF (nBaf) BibTex
2025-01-06 R-HSA-9933237 PBRM1-containing ATPase complex binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD&:PHF10 BibTex
2025-01-06 R-HSA-9932843 PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7 BibTex
2025-01-06 R-HSA-9932832 BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 BibTex
2025-01-06 R-HSA-9932440 ARID2 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1 BibTex
2025-01-06 R-HSA-9932449 SMARCE1 and SMARCB1 bind SMARCC dimer:SMARCDs BibTex
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Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand BibTex
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Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9725885 P4 bind PGR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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