Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/260)
Date Identifier Pathway Reference
2025-07-02 R-HSA-9955698 Diseases of the urea cycle BibTex
2025-07-02 R-HSA-9956520 ASS1 variants cause citrullinemia BibTex
2025-07-02 R-HSA-9955542 CPS1 variants cause CPS1 deficiency BibTex
2025-07-02 R-HSA-9956514 ARG1 variants cause hyperargininemia BibTex
2025-07-02 R-HSA-9956529 ASL variants cause argininosuccinate aciduria BibTex
2025-07-02 R-HSA-9955693 NAGS variants cause NAGS deficiency BibTex
2025-07-02 R-HSA-9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome BibTex
2025-07-02 R-HSA-9956551 OTC leader sequence variants cause OTC deficiency BibTex
2025-07-02 R-HSA-9956553 OTC main chain variants cause OTC deficiency BibTex
2025-07-02 R-HSA-9956522 OTC variants cause OTC deficiency BibTex
2025-01-06 R-HSA-9932444 ATP-dependent chromatin remodelers BibTex
2025-01-06 R-HSA-9932451 SWI/SNF chromatin remodelers BibTex
2025-01-06 R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex BibTex
2025-01-06 R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex BibTex
2025-01-06 R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) BibTex
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Authored Reactions (15/1,574)
Date Identifier Reaction Reference
2025-07-02 R-HSA-9956517 ASS1 variants don't synthesize arginosuccinate BibTex
2025-07-02 R-HSA-9956502 OTC precursor is targeted to the mitochondrial matrix and processed BibTex
2025-07-02 R-HSA-9955504 SIRT5 deglutarylates CPS1 BibTex
2025-07-02 R-HSA-9955518 SIRT5 desuccinylates CPS1 BibTex
2025-07-02 R-MMU-9955513 Sirt5 desuccinylates Cps1 BibTex
2025-07-02 R-HSA-9959863 TP53 binds OTC gene BibTex
2025-07-02 R-HSA-9959860 TP53 binds CPS1 gene BibTex
2025-07-02 R-HSA-9959857 TP53 binds ARG1 gene BibTex
2025-07-02 R-HSA-9959871 ARG1 gene expression BibTex
2025-07-02 R-HSA-9959874 CPS1 gene expression BibTex
2025-07-02 R-HSA-9959881 OTC gene expression BibTex
2025-07-02 R-HSA-9955543 CPS1 variants don't synthesize carbamoyl phosphate BibTex
2025-07-02 R-HSA-9956512 ARG1 variants don't synthesize urea and ornithine BibTex
2025-07-02 R-HSA-9956524 ASL variants don't synthesize fumarate and arginine BibTex
2025-07-02 R-HSA-9955697 NAGS variants don't synthesize N-acetylglutamate BibTex
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Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand BibTex
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Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9725885 P4 bind PGR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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