The COG complex binds RABs at the Golgi membrane

Stable Identifier
R-HSA-8849748
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
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The COG complex binds RABs at the Golgi membrane
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Large scale screens have identified numerous RAB proteins that interact with components of the COG complex (Fukuda et al, 2008; Miller et al, 2013; reviewed in Willet et al, 2013). Although RAB proteins are known to play key roles in trafficking and Golgi structure and function, the significance of some of these interactions is not yet clear (Kelly et al, 2012; Liu et al, 2013; reviewed in Liu and Storrie, 2015).
Literature References
PubMed ID Title Journal Year
25708460 How Rab proteins determine Golgi structure

Storrie, B, Liu, S

Int Rev Cell Mol Biol 2015
23239882 Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF)

Ungar, D, Lowe, M, Lupashin, VV, Rofe, AP, Sharma, P, Miller, VJ, Watson, IJ, Frost, L, Kudlyk, TA, Duden, R

J. Biol. Chem. 2013
23936529 Rab41 is a novel regulator of Golgi apparatus organization that is needed for ER-to-Golgi trafficking and cell growth

Hunt, L, Storrie, B, Liu, S

PLoS ONE 2013
18256213 Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity

Fukuda, M, Itoh, T, Kanno, E, Ishibashi, K

Mol. Cell Proteomics 2008
22188167 Rab30 is required for the morphological integrity of the Golgi apparatus

McCaffrey, MW, Kelly, EE, Jollivet, F, Giordano, F, Raposo, G, Horgan, CP

Biol. Cell 2012
23839779 The Golgi puppet master: COG complex at center stage of membrane trafficking interactions

Ungar, D, Lupashin, V, Willett, R

Histochem. Cell Biol. 2013
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Orthologous Events
The COG complex binds RABs at the Golgi membrane (Bos taurus)
The COG complex binds RABs at the Golgi membrane (Caenorhabditis elegans)
The COG complex binds RABs at the Golgi membrane (Canis familiaris)
The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)
The COG complex binds RABs at the Golgi membrane (Drosophila melanogaster)
The COG complex binds RABs at the Golgi membrane (Gallus gallus)
The COG complex binds RABs at the Golgi membrane (Mus musculus)
The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)
The COG complex binds RABs at the Golgi membrane (Sus scrofa)
The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-12-17)
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