RAB33B:GTP binds RIC1:RGP1

Stable Identifier
R-HSA-8847887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Medial Golgi protein RAB33B binds to both components of the RAB6 GEF complex RIC1:RGP1, and interacts with the RIC1 subunit at a site that is distinct from the RAB6-interacting site. Activated RAB33B does not change the RAB6-directed GEF activity of the RIC1:RGP1 complex, nor does it affect RAB6 binding, however overexpression of RAB33B leads to loss of RAB6 from the Golgi (Starr et al, 2010; Pusapati et al, 2012). The significance of the interaction between RAB33B and the RIC1:RGP1 complex remains to be elucidated, however it is possible that RAB6 and RAB33B form a sequential RAB cascade that contributes to COPI-dependent retrograde traffic from the trans- to medial- Golgi.

Literature References
PubMed ID Title Journal Year
20163571 Rab33b and Rab6 are functionally overlapping regulators of Golgi homeostasis and trafficking

Starr, T, Sun, Y, Wilkins, N, Storrie, B

Traffic 2010
23091056 Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase

Pusapati, GV, Luchetti, G, Pfeffer, SR

J. Biol. Chem. 2012
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