Reactome | RAB33B:GTP binds RIC1:RGP1

RAB33B:GTP binds RIC1:RGP1

Stable Identifier

R-HSA-8847887

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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Medial Golgi protein RAB33B binds to both components of the RAB6 GEF complex RIC1:RGP1, and interacts with the RIC1 subunit at a site that is distinct from the RAB6-interacting site. Activated RAB33B does not change the RAB6-directed GEF activity of the RIC1:RGP1 complex, nor does it affect RAB6 binding, however overexpression of RAB33B leads to loss of RAB6 from the Golgi (Starr et al, 2010; Pusapati et al, 2012). The significance of the interaction between RAB33B and the RIC1:RGP1 complex remains to be elucidated, however it is possible that RAB6 and RAB33B form a sequential RAB cascade that contributes to COPI-dependent retrograde traffic from the trans- to medial- Golgi.

Literature References

PubMed ID	Title	Journal	Year
23091056	Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase Pfeffer, SR, Luchetti, G, Pusapati, GV	J. Biol. Chem.	2012
20163571	Rab33b and Rab6 are functionally overlapping regulators of Golgi homeostasis and trafficking Storrie, B, Wilkins, N, Starr, T, Sun, Y	Traffic	2010