The COG tethering complex interacts with numerous SNAREs at the Golgi membrane

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Octameric COG (Conserved Oligomeric Golgi) is a Golgi localized tethering complex that aids in the capture of vesicles during intra-Golgi traffic as well as the capture of retrograde vesicles from the endosome at the trans-Golgi network (Zolov and Lupashin, 2005; reviewed in Willet et al, 2013a). Consistent with this, the COG complex interacts with many of the proteins involved in vesicle targeting, including SNAREs, coat proteins and RABs, among others. At the Golgi, COG has been shown to interact with Golgi SNAREs STX6, STX6, STX16, GOSR1, GOSR2, BET1L, SNAP29, VPS45 and VTI1A, but not other Golgi SNAREs and not ERGIC-resident SNAREs (Suvorora et al, 2002; Laufman et al, 2009; Laufman et al, 2011; Laufman et al, 2013; Shestakova et al, 2007; Willet et al, 2013b). The function of each of these COG-Golgi SNARE interactions has not yet been characterized in full detail (reviewed in Willet et al, 2013a).

Literature References
PubMed ID Title Journal Year
19536132 Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing

Laufman, O, Kedan, A, Hong, W, Lev, S

EMBO J. 2009
21807881 The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport

Laufman, O, Hong, W, Lev, S

J. Cell Biol. 2011
23378023 The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes

Laufman, O, Hong, W, Lev, S

J. Cell. Sci. 2013
15728195 Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells

Zolov, SN, Lupashin, VV

J. Cell Biol. 2005
12011112 The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins

Suvorova, ES, Duden, R, Lupashin, VV

J. Cell Biol. 2002
23462996 COG complexes form spatial landmarks for distinct SNARE complexes

Willett, R, Kudlyk, T, Pokrovskaya, I, Schönherr, R, Ungar, D, Duden, R, Lupashin, V

Nat Commun 2013
18086915 Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability

Shestakova, A, Suvorova, E, Pavliv, O, Khaidakova, G, Lupashin, V

J. Cell Biol. 2007
23839779 The Golgi puppet master: COG complex at center stage of membrane trafficking interactions

Willett, R, Ungar, D, Lupashin, V

Histochem. Cell Biol. 2013
Participant Of
Orthologous Events
Cite Us!