Reactome | COPI-mediated anterograde transport

COPI-mediated anterograde transport

Stable Identifier

R-HSA-6807878

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
22013193	COPII and COPI traffic at the ER-Golgi interface Szul, T, Sztul, E	Physiology (Bethesda)	2011
10825291	COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP	J Cell Sci	2000
8334707	Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo Pepperkok, R, Scheel, J, Horstmann, H, Hauri, HP, Griffiths, G, Kreis, TE	Cell	1993
9288971	ER-to-Golgi transport visualized in living cells Presley, JF, Cole, NB, Schroer, TA, Hirschberg, K, Zaal, KJ, Lippincott-Schwartz, J	Nature	1997
23732476	Retrograde traffic from the Golgi to the endoplasmic reticulum Spang, A	Cold Spring Harb Perspect Biol	2013
9323141	Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI Scales, SJ, Pepperkok, R, Kreis, TE	Cell	1997
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Lord, C, Ferro-Novick, S, Miller, EA	Cold Spring Harb Perspect Biol	2013
15632110	Live imaging of bidirectional traffic from the ERGIC Ben-Tekaya, H, Miura, K, Pepperkok, R, Hauri, HP	J. Cell. Sci.	2005