Reactome | COPI-mediated anterograde transport

COPI-mediated anterograde transport

Stable Identifier

R-HSA-6807878

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
10825291	COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R	J Cell Sci	2000
8334707	Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo Scheel, J, Hauri, HP, Griffiths, G, Horstmann, H, Kreis, TE, Pepperkok, R	Cell	1993
9288971	ER-to-Golgi transport visualized in living cells Presley, JF, Lippincott-Schwartz, J, Hirschberg, K, Cole, NB, Zaal, KJ, Schroer, TA	Nature	1997
23732476	Retrograde traffic from the Golgi to the endoplasmic reticulum Spang, A	Cold Spring Harb Perspect Biol	2013
9323141	Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI Scales, SJ, Kreis, TE, Pepperkok, R	Cell	1997
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Ferro-Novick, S, Miller, EA, Lord, C	Cold Spring Harb Perspect Biol	2013
15632110	Live imaging of bidirectional traffic from the ERGIC Hauri, HP, Ben-Tekaya, H, Pepperkok, R, Miura, K	J. Cell. Sci.	2005