The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).
Sztul, E, Szul, T
Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R
Scheel, J, Hauri, HP, Griffiths, G, Horstmann, H, Kreis, TE, Pepperkok, R
Presley, JF, Lippincott-Schwartz, J, Hirschberg, K, Cole, NB, Zaal, KJ, Schroer, TA
Spang, A
Scales, SJ, Kreis, TE, Pepperkok, R
Ferro-Novick, S, Miller, EA, Lord, C
Hauri, HP, Ben-Tekaya, H, Pepperkok, R, Miura, K
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