Reactome | RAB1:GTP recruits GBF1 to the ERGIC

RAB1:GTP recruits GBF1 to the ERGIC

Stable Identifier

R-HSA-6807864

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)

General

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In its GTP-bound active state, RAB1 recruits the ARF GEF GBF1 to the ERGIC (Monetta et al, 2007). GBF1 is the only ARF activator required for the formation of COPI coats, and it therefore has roles in the anterograde ERGIC-to-cis-Golgi pathway as well as in COPI-mediated retrograde transport within the Golgi and back to the ERGIC and ER (Kawamoto et al, 2002; Szul et al, 2005; Zhao et al, 2006; Szul et al, 2007; reviewed in Szul and Sztul, 2011). GBF1 activates ARF4 which is concentrated at the ERGIC compartment, but also ARF1 and ARF5 which have more generalized localization within the secretory pathway (Volpicelli-Daley et al, 2005; Chun et al, 2008; reviewed in D'Souza-Schorey and Chavrier, 2006). GBF1 also interacts with the USO1 homodimer, a long coiled-coil tethering factor (Garcia-Mata and Sztul, 2003).

Literature References

PubMed ID	Title	Journal	Year
12634853	The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor Sztul, E, Garcia-Mata, R	EMBO Rep.	2003
12047556	GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat Yoshida, Y, Tamaki, H, Kawamoto, K, Yamashina, S, Nakayama, K, Torii, S, Shinotsuka, C	Traffic	2002
18524849	Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1 Presley, JF, Melançon, P, Chun, J, Dejgaard, SY, Shapovalova, Z	Mol. Biol. Cell	2008
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
17429068	Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association Slavin, I, Monetta, P, Romero, N, Alvarez, C	Mol. Biol. Cell	2007
16030262	Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic Volpicelli-Daley, LA, Zhang, CJ, Li, Y, Kahn, RA	Mol. Biol. Cell	2005
15813748	Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1 Shestopal, S, Sztul, E, Szul, T, Alvarez, C, Brandon, E, Garcia-Mata, R	Traffic	2005
16926190	GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic Presley, JF, Melançon, P, Claude, A, Zhao, X, Chun, J, Shields, DJ	J. Cell. Sci.	2006
16633337	ARF proteins: roles in membrane traffic and beyond Chavrier, P, D'Souza-Schorey, C	Nat. Rev. Mol. Cell Biol.	2006
17956946	Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking Grabski, R, Shestopal, S, Morohashi, Y, Lyons, S, Sztul, E, Szul, T, Lowe, M	J. Cell. Sci.	2007