Reactome | GBF1 stimulates ARF nucleotide exchange

GBF1 stimulates ARF nucleotide exchange

Stable Identifier

R-HSA-6807868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        GBF1 stimulates ARF nucleotide exchange (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GBF1 facilitates the exchange of GDP for GTP, activating ARF (Niu et al, 2005; Szul et al, 2005; Szul et al, 2007; Kawamoto et al, 2002; reviewed in Szul and Sztul, 2011).

Literature References

PubMed ID	Title	Journal	Year
15616190	Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi Niu, TK, Pfeifer, AC, Lippincott-Schwartz, J, Jackson, CL	Mol. Biol. Cell	2005
12047556	GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat Kawamoto, K, Yoshida, Y, Tamaki, H, Torii, S, Shinotsuka, C, Yamashina, S, Nakayama, K	Traffic	2002
22013193	COPII and COPI traffic at the ER-Golgi interface Szul, T, Sztul, E	Physiology (Bethesda)	2011
15813748	Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1 Szul, T, Garcia-Mata, R, Brandon, E, Shestopal, S, Alvarez, C, Sztul, E	Traffic	2005
17956946	Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking Szul, T, Grabski, R, Lyons, S, Morohashi, Y, Shestopal, S, Lowe, M, Sztul, E	J. Cell. Sci.	2007