Reactome | Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex

Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex

Stable Identifier

R-HSA-6809006

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)

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Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex

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Vesicles tethering at the cis-Golgi is mediated both by long coiled-coil tethers and by large multisubunit complexes. Vesicle-bound USO1 homodimers associate with the Golgi localized GOLGA2:GORASP1 complex and with the Golgi-localized octameric COG tethering complex (Allan et al, 2000; Moyer et al, 2001; Weide et al, 2001; Nakamura et al, 1997; Seeman et al, 2000; Sohda et al, 2007). GOLGB1 is another Golgi localized tether that may facilitate vesicle tethering at the cis-Golgi, although it is also implicated in intra-Golgi retrograde trafficking (Linstedt and Hauri, 1993; Sonnichsen et al, 1998; Alvarez et al, 2001; Beard et al, 2005; reviewed in Appenzeller-Herzog et al, 2006). In addition to binding to USO1, the COG complex also interacts with components of the COPI coat, as well as with SNARE proteins and the TMEM115 protein (Suvorova et al, 2002; Zolov et al, 2005; Shestakova et al, 2007; Ong et al, 2014; reviewed in Willet et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
15728195	Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells Lupashin, VV, Zolov, SN	J. Cell Biol.	2005
17274799	The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity Ogata, S, Sohda, M, Ikehara, Y, Fusano, T, Sakisaka, S, Nakamura, N, Misumi, Y, Yoshimura, S	Traffic	2007
9150144	The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner Warren, G, Levine, TP, Lowe, M, Rabouille, C, Nakamura, N	Cell	1997
11035033	The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic Hauri, HP, Sztul, E, Alvarez, C, Garcia-Mata, R	J. Biol. Chem.	2001
11306556	The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b Weide, T, Köster, M, Barnekow, A, Bayer, M, Siebrasse, JP, Peters, R	EMBO Rep.	2001
10903204	Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion Allan, BB, Balch, WE, Moyer, BD	Science	2000
23839779	The Golgi puppet master: COG complex at center stage of membrane trafficking interactions Ungar, D, Lupashin, V, Willett, R	Histochem. Cell Biol.	2013
9490716	A role for giantin in docking COPI vesicles to Golgi membranes Warren, G, Dirac-Svejstrup, B, Lowe, M, Levine, T, Jämsä, E, Sönnichsen, B	J. Cell Biol.	1998
11285137	Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering Allan, BB, Balch, WE, Moyer, BD	Traffic	2001
7691276	Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa Hauri, HP, Linstedt, AD	Mol. Biol. Cell	1993
16723730	The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function Hauri, HP, Appenzeller-Herzog, C	J. Cell. Sci.	2006
18086915	Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability Shestakova, A, Suvorova, E, Pavliv, O, Lupashin, V, Khaidakova, G	J. Cell Biol.	2007
24806965	TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport Hong, W, Ong, YS, Gounko, NV, Tran, TH	J. Cell. Sci.	2014
15878873	A cryptic Rab1-binding site in the p115 tethering protein Warren, G, Satoh, A, Shorter, J, Beard, M	J. Biol. Chem.	2005
10679020	The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo Seemann, J, Jokitalo, EJ, Warren, G	Mol. Biol. Cell	2000