Reactome | ERGIC-to-Golgi vesicles bind dynein:dynactin

ERGIC-to-Golgi vesicles bind dynein:dynactin

Stable Identifier

R-HSA-6809003

Type

Reaction [binding]

Species

Homo sapiens

Compartment

transport vesicle

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)

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ERGIC-to-Golgi vesicles bind dynein:dynactin

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Unlike COPII-mediated traffic from the ER, COPI traffic to the Golgi is microtubule- and dynein-dependent (Scales et al, 1997; Presley et al, 1997; Ben-Tekaya et al, 2005). Recruitment of the dynein:dynactin complex may in turn rely on interaction with the ankyrin-spectrin network, which may contact integral membrane cargo proteins as they are incorporated into nascent COPI vesicles (Devarajan et al, 1997; Godi et al, 1998; Holleran et al, 1996; Holleran et al, 2001). Although not depicted in this reaction, dynein-dependent vesicle transport is energy dependent.

Literature References

PubMed ID	Title	Journal	Year
11461920	beta III spectrin binds to the Arp1 subunit of dynactin Holleran, EA, Ligon, LA, Tokito, M, Stankewich, MC, Morrow, JS, Holzbaur, EL	J. Biol. Chem.	2001
9288971	ER-to-Golgi transport visualized in living cells Presley, JF, Cole, NB, Schroer, TA, Hirschberg, K, Zaal, KJ, Lippincott-Schwartz, J	Nature	1997
8991093	Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles Holleran, EA, Tokito, MK, Karki, S, Holzbaur, EL	J. Cell Biol.	1996
9323141	Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI Scales, SJ, Pepperkok, R, Kreis, TE	Cell	1997
9671725	ADP ribosylation factor regulates spectrin binding to the Golgi complex Godi, A, Santone, I, Pertile, P, Devarajan, P, Stabach, PR, Morrow, JS, Di Tullio, G, Polishchuk, R, Petrucci, TC, Luini, A, De Matteis, MA	Proc. Natl. Acad. Sci. U.S.A.	1998
15632110	Live imaging of bidirectional traffic from the ERGIC Ben-Tekaya, H, Miura, K, Pepperkok, R, Hauri, HP	J. Cell. Sci.	2005
9380700	Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells Devarajan, P, Stabach, PR, De Matteis, MA, Morrow, JS	Proc. Natl. Acad. Sci. U.S.A.	1997