Unlike COPII-mediated traffic from the ER, COPI traffic to the Golgi is microtubule- and dynein-dependent (Scales et al, 1997; Presley et al, 1997; Ben-Tekaya et al, 2005). Recruitment of the dynein:dynactin complex may in turn rely on interaction with the ankyrin-spectrin network, which may contact integral membrane cargo proteins as they are incorporated into nascent COPI vesicles (Devarajan et al, 1997; Godi et al, 1998; Holleran et al, 1996; Holleran et al, 2001). Although not depicted in this reaction, dynein-dependent vesicle transport is energy dependent.
Morrow, JS, Stankewich, MC, Ligon, LA, Tokito, M, Holzbaur, EL, Holleran, EA
Presley, JF, Lippincott-Schwartz, J, Hirschberg, K, Cole, NB, Zaal, KJ, Schroer, TA
Karki, S, Holzbaur, EL, Tokito, MK, Holleran, EA
Scales, SJ, Kreis, TE, Pepperkok, R
Godi, A, Di Tullio, G, Morrow, JS, Santone, I, Stabach, PR, Luini, A, Polishchuk, R, Devarajan, P, Pertile, P, De Matteis, MA, Petrucci, TC
Hauri, HP, Ben-Tekaya, H, Pepperkok, R, Miura, K
Morrow, JS, Stabach, PR, Devarajan, P, De Matteis, MA
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