ERGIC-to-Golgi vesicles bind dynein:dynactin

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Unlike COPII-mediated traffic from the ER, COPI traffic to the Golgi is microtubule- and dynein-dependent (Scales et al, 1997; Presley et al, 1997; Ben-Tekaya et al, 2005). Recruitment of the dynein:dynactin complex may in turn rely on interaction with the ankyrin-spectrin network, which may contact integral membrane cargo proteins as they are incorporated into nascent COPI vesicles (Devarajan et al, 1997; Godi et al, 1998; Holleran et al, 1996; Holleran et al, 2001). Although not depicted in this reaction, dynein-dependent vesicle transport is energy dependent.

Literature References
PubMed ID Title Journal Year
9288971 ER-to-Golgi transport visualized in living cells

Presley, JF, Cole, NB, Schroer, TA, Hirschberg, K, Zaal, KJ, Lippincott-Schwartz, J

Nature 1997
11461920 beta III spectrin binds to the Arp1 subunit of dynactin

Holleran, EA, Ligon, LA, Tokito, M, Stankewich, MC, Morrow, JS, Holzbaur, EL

J. Biol. Chem. 2001
8991093 Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles

Holleran, EA, Tokito, MK, Karki, S, Holzbaur, EL

J. Cell Biol. 1996
9323141 Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI

Scales, SJ, Pepperkok, R, Kreis, TE

Cell 1997
9671725 ADP ribosylation factor regulates spectrin binding to the Golgi complex

Godi, A, Santone, I, Pertile, P, Devarajan, P, Stabach, PR, Morrow, JS, Di Tullio, G, Polishchuk, R, Petrucci, TC, Luini, A, De Matteis, MA

Proc. Natl. Acad. Sci. U.S.A. 1998
15632110 Live imaging of bidirectional traffic from the ERGIC

Ben-Tekaya, H, Miura, K, Pepperkok, R, Hauri, HP

J. Cell. Sci. 2005
9380700 Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells

Devarajan, P, Stabach, PR, De Matteis, MA, Morrow, JS

Proc. Natl. Acad. Sci. U.S.A. 1997
Participant Of
Orthologous Events
Cite Us!