Reactome | ARFGAPs stimulate ARF GTPase activity

ARFGAPs stimulate ARF GTPase activity

Stable Identifier

R-HSA-6807877

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)

General

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The ARFGAP proteins stimulates ARF GTPase activity, promoting the release of the nascent COPI vesicle from the membrane and release of ARF:ADP (Tanigawa et al, 1993; reviewed in Beck et al, 2009; East and Kahn, 2011). Although this reaction shows their dissociation, it is not clear whether ARFGAPs persist on the COPI vesicle after GTP hydrolysis, nor is it known when GBF is released from the nascent COPI vesicle.

Literature References

PubMed ID	Title	Journal	Year
19631211	The COPI system: molecular mechanisms and function Beck, R, Rawet, M, Ravet, M, Wieland, FT, Cassel, D	FEBS Lett.	2009
8253837	Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles Tanigawa, G, Orci, L, Amherdt, M, Ravazzola, M, Helms, JB, Rothman, JE	J. Cell Biol.	1993
20637885	Models for the functions of Arf GAPs East, MP, Kahn, RA	Semin. Cell Dev. Biol.	2011

Participants

Input

RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Output

Participates

as an event of

COPI-mediated anterograde transport (Homo sapiens)

Catalyst Activity

GTPase activity of RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane]

Physical Entity

RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Activity

GTPase activity (GO:0003924)

Orthologous Events

ARFGAPs stimulate ARF GTPase activity (Bos taurus)

ARFGAPs stimulate ARF GTPase activity (Caenorhabditis elegans)

ARFGAPs stimulate ARF GTPase activity (Canis familiaris)

ARFGAPs stimulate ARF GTPase activity (Danio rerio)

ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)

ARFGAPs stimulate ARF GTPase activity (Drosophila melanogaster)

ARFGAPs stimulate ARF GTPase activity (Gallus gallus)