Reactome | COPI vesicle uncoating

COPI vesicle uncoating

Stable Identifier

R-HSA-6809010

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)

General

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The mechanisms of COPI vesicle uncoating are not well established (reviewed in Szul and Sztul, 2011). Coat dissociation may be promoted by changes in protein-protein interactions upon vesicle tethering, as has been suggested for retrograde COPI-traffic to the ER (Zink et al, 2009). After uncoating and membrane fusion, the SNARE complex exists as a four-helix bundle that must be "unzipped" (dissociated) by NSF for reuse, an energetically costly event (reviewed in Hong and Lev, 2014; Sudhof and Rothman, 2009).

Literature References

PubMed ID	Title	Journal	Year
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
24119662	Tethering the assembly of SNARE complexes Hong, W, Lev, S	Trends Cell Biol.	2014
19164740	Membrane fusion: grappling with SNARE and SM proteins Südhof, TC, Rothman, JE	Science	2009
19758564	A link between ER tethering and COP-I vesicle uncoating Wenzel, D, Zink, S, Schmitt, HD, Wurm, CA	Dev. Cell	2009