COPI vesicle uncoating

Stable Identifier
R-HSA-6809010
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
COPI vesicle uncoating
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The mechanisms of COPI vesicle uncoating are not well established (reviewed in Szul and Sztul, 2011). Coat dissociation may be promoted by changes in protein-protein interactions upon vesicle tethering, as has been suggested for retrograde COPI-traffic to the ER (Zink et al, 2009). After uncoating and membrane fusion, the SNARE complex exists as a four-helix bundle that must be "unzipped" (dissociated) by NSF for reuse, an energetically costly event (reviewed in Hong and Lev, 2014; Sudhof and Rothman, 2009).
Literature References
PubMed ID Title Journal Year
22013193 COPII and COPI traffic at the ER-Golgi interface

Szul, T, Sztul, E

Physiology (Bethesda) 2011
24119662 Tethering the assembly of SNARE complexes

Hong, W, Lev, S

Trends Cell Biol. 2014
19164740 Membrane fusion: grappling with SNARE and SM proteins

Südhof, TC, Rothman, JE

Science 2009
19758564 A link between ER tethering and COP-I vesicle uncoating

Zink, S, Wenzel, D, Wurm, CA, Schmitt, HD

Dev. Cell 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
COPI vesicle uncoating (Canis familiaris)
COPI vesicle uncoating (Mus musculus)
COPI vesicle uncoating (Rattus norvegicus)
Authored
Rothfels, K  (2015-11-03)
Reviewed
Gillespie, ME  (2015-09-02)
Created
Rothfels, K  (2015-11-09)
Cite Us!