COPI vesicle uncoating

Stable Identifier
Reaction [uncertain]
Homo sapiens
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The mechanisms of COPI vesicle uncoating are not well established (reviewed in Szul and Sztul, 2011). Coat dissociation may be promoted by changes in protein-protein interactions upon vesicle tethering, as has been suggested for retrograde COPI-traffic to the ER (Zink et al, 2009). After uncoating and membrane fusion, the SNARE complex exists as a four-helix bundle that must be "unzipped" (dissociated) by NSF for reuse, an energetically costly event (reviewed in Hong and Lev, 2014; Sudhof and Rothman, 2009).

Literature References
PubMed ID Title Journal Year
22013193 COPII and COPI traffic at the ER-Golgi interface

Sztul, E, Szul, T

Physiology (Bethesda) 2011
24119662 Tethering the assembly of SNARE complexes

Hong, W, Lev, S

Trends Cell Biol. 2014
19164740 Membrane fusion: grappling with SNARE and SM proteins

S├╝dhof, TC, Rothman, JE

Science 2009
19758564 A link between ER tethering and COP-I vesicle uncoating

Wenzel, D, Zink, S, Schmitt, HD, Wurm, CA

Dev. Cell 2009
Orthologous Events
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