Reactome | KDSR [endoplasmic reticulum membrane]

KDSR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428134

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-ketodihydrosphingosine reductase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q06136 KDSR

Gene Names

KDSR, FVT1, SDR35C1

Chain

signal peptide:1-25, chain:26-332

Reference Genes

BioGPS Gene:2531 KDSR

COSMIC (genes):KDSR KDSR

CTD Gene:2531 KDSR

dbSNP Gene:2531 KDSR

ENSEMBL:ENSG00000119537 KDSR

HGNC:4021 KDSR

KEGG:hsa:2531 KDSR

Monarch:2531 KDSR

NCBI Gene:2531 KDSR

OMIM:136440 KDSR

UCSC:Q06136 KDSR

Reference Transcript

RefSeq:NM_002035.2 KDSR

Other Identifiers

11730180_s_at

11730181_s_at

11751627_a_at

1558279_3p_a_at

1558279_PM_a_at

1558279_a_at

16855684

202419_PM_at

202419_at

229850_PM_at

229850_at

2531

36120_at

3811451

3811456

3811457

3811460

3811461

3811462

3811463

3811464

3811465

3811466

3811469

3811470

3811471

3811474

3811475

3811476

3811477

3811478

3811479

3811480

3811481

3811482

3811485

3811486

3811487

3811488

3811489

3811493

3811494

44592_at

56732_at

8023656

80607_i_at

80610_r_at

A_23_P27367

A_23_P38770

A_32_P515088

GE59896

GO:0000166

GO:0003824

GO:0005515

GO:0005615

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0006666

GO:0016020

GO:0016491

GO:0030148

GO:0043226

GO:0044255

GO:0047560

GO:0070402

HMNXSV003015511

Hs.32250.0.A1_3p_at

Hs2.96343.1.S1_3p_x_at

ILMN_2154052

ILMN_2154053

PH_hs_0004234

TC18000556.hg

TC18000953.hg

X63657_at

g4503816_3p_at

Inferred To

Kdsr [endoplasmic reticulum membrane] (Drosophila melanogaster)

Kdsr [endoplasmic reticulum membrane] (Rattus norvegicus)

kdsr [endoplasmic reticulum membrane] (Xenopus tropicalis)

KDSR [endoplasmic reticulum membrane] (Bos taurus)

KDSR [endoplasmic reticulum membrane] (Caenorhabditis elegans)

KDSR [endoplasmic reticulum membrane] (Canis familiaris)

KDSR [endoplasmic reticulum membrane] (Dictyostelium discoideum)

KDSR [endoplasmic reticulum membrane] (Mus musculus)

KDSR [endoplasmic reticulum membrane] (Plasmodium falciparum)

KDSR [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

KDSR [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

KDSR [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2463

ENSEMBL

ENST00000326575, ENST00000645214, ENSP00000494352, ENSP00000312939

OpenTargets

ENSG00000119537

IntEnz

1.1.1.102

HPA

ENSG00000119537-KDSR

PRO

Q06136

Pharos - Targets

Q06136

HMDB Protein

HMDBP03056

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q8IUW5 RELL1			0.527	2
UniProt:Q00765 REEP5			0.527	4
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	3