Reactome | KDSR [endoplasmic reticulum membrane]

KDSR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428134

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-ketodihydrosphingosine reductase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q06136 KDSR

Gene Names

KDSR, FVT1, SDR35C1

Chain

signal peptide:1-25, chain:26-332

Reference Genes

BioGPS Gene:2531 KDSR

COSMIC (genes):KDSR KDSR

CTD Gene:2531 KDSR

dbSNP Gene:2531 KDSR

ENSEMBL:ENSG00000119537 KDSR

ENSEMBL:ENSG00000119537.18 KDSR

HGNC:4021 KDSR

KEGG Gene (Homo sapiens):2531 KDSR

Monarch:2531 KDSR

NCBI Gene:2531 KDSR

OMIM:136440 KDSR

UCSC:Q06136 KDSR

Reference Transcript

RefSeq:NM_002035.2 KDSR

Other Identifiers

11730180_s_at

11730181_s_at

11751627_a_at

1558279_3p_a_at

1558279_PM_a_at

1558279_a_at

16855684

202419_PM_at

202419_at

229850_PM_at

229850_at

2531

36120_at

3811451

3811456

3811457

3811460

3811461

3811462

3811463

3811464

3811465

3811466

3811469

3811471

3811476

3811481

3811482

3811485

3811486

3811488

3811489

3811493

3811494

44592_at

56732_at

8023656

80607_i_at

80610_r_at

A_23_P27367

A_23_P38770

A_32_P515088

GE59896

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0006666

GO:0016020

GO:0016491

GO:0030148

GO:0043226

GO:0047560

HMNXSV003015511

Hs.32250.0.A1_3p_at

Hs2.96343.1.S1_3p_x_at

ILMN_2154052

ILMN_2154053

PH_hs_0004234

TC18000556.hg

TC18000953.hg

X63657_at

g4503816_3p_at

Inferred To

Kdsr [endoplasmic reticulum membrane] (Drosophila melanogaster)

Kdsr [endoplasmic reticulum membrane] (Rattus norvegicus)

fvt1 [endoplasmic reticulum membrane] (Danio rerio)

ksrA-1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

kdsr [endoplasmic reticulum membrane] (Xenopus tropicalis)

KDSR [endoplasmic reticulum membrane] (Bos taurus)

KDSR [endoplasmic reticulum membrane] (Caenorhabditis elegans)

KDSR [endoplasmic reticulum membrane] (Canis familiaris)

KDSR [endoplasmic reticulum membrane] (Mus musculus)

KDSR [endoplasmic reticulum membrane] (Plasmodium falciparum)

KDSR [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

KDSR [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

KDSR [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_002026.1

Guide to Pharmacology - Targets

2463

OpenTargets

ENSG00000119537

GeneCards

Q06136

HPA

ENSG00000119537-KDSR

Ensembl

ENSP00000494352, ENSP00000312939, ENST00000645214, ENST00000326575, ENSG00000119537

PRO

Q06136

Pharos - Targets

Q06136

HMDB Protein

HMDBP03056

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3

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