Reactome | RBP4(19-201) [extracellular region]

RBP4(19-201) [extracellular region]

Stable Identifier

R-HSA-2453675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

RBP4, Retinol-binding protein 4, RET4_HUMAN, RBP

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of the neuronal system (Homo sapiens)
  - Diseases associated with visual transduction (Homo sapiens)
    - Retinoid cycle disease events (Homo sapiens)
      - Defective visual phototransduction due to STRA6 loss of function (Homo sapiens)
        
        Defective STRA6 does not transport atROL (Homo sapiens)
        
        TTR:RBP4:atROL:STRA6 mutants [plasma membrane] (Homo sapiens)
        
        TTR:RBP4:atROL [extracellular region] (Homo sapiens)
        
        RBP4:atROL [extracellular region] (Homo sapiens)
        
        RBP4(19-201) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02753 RBP4

Gene Names

RBP4, PRO2222

Chain

signal peptide:1-18, chain:19-201, chain:19-200, chain:19-199, chain:19-197, chain:19-194

Reference Genes

BioGPS Gene:5950 RBP4

COSMIC (genes):RBP4 RBP4

CTD Gene:5950 RBP4

dbSNP Gene:5950 RBP4

ENSEMBL:ENSG00000138207 RBP4

HGNC:9922 RBP4

KEGG:hsa:5950 RBP4

Monarch:5950 RBP4

NCBI Gene:5950 RBP4

OMIM:180250 RBP4

UCSC:P02753 RBP4

Reference Transcript

Other Identifiers

11718132_at

16716659

219140_PM_s_at

219140_s_at

32552_at

3300753

3300754

3300755

3300756

3300761

3300769

3300770

3300774

3300775

3300776

3300777

3300778

5950

7935116

A_23_P75283

GE58418

GO:0001654

GO:0002639

GO:0005215

GO:0005501

GO:0005515

GO:0005576

GO:0005615

GO:0005975

GO:0006094

GO:0006629

GO:0007507

GO:0007601

GO:0008289

GO:0016918

GO:0019841

GO:0022414

GO:0022600

GO:0030277

GO:0030324

GO:0032024

GO:0032526

GO:0034632

GO:0034633

GO:0042572

GO:0042593

GO:0043226

GO:0048562

GO:0048706

GO:0048738

GO:0048807

GO:0048856

GO:0050877

GO:0060044

GO:0060059

GO:0060065

GO:0060068

GO:0060157

GO:0060347

GO:0070062

HMNXSV003024730

ILMN_1814719

TC10001537.hg

X00129_at

g8400727_3p_a_at

Participates

as an input of

RBP4 binds atROL (Homo sapiens)

as a component of

Other forms of this molecule

RBP4 I41N [extracellular region]

RBP4 G75D [extracellular region]

Inferred To

rbp4 [extracellular region] (Xenopus tropicalis)

RBP4(19-201) [extracellular region] (Bos taurus)

RBP4(19-201) [extracellular region] (Canis familiaris)

RBP4(19-201) [extracellular region] (Danio rerio)

RBP4(19-201) [extracellular region] (Gallus gallus)

RBP4(19-201) [extracellular region] (Mus musculus)

RBP4(19-201) [extracellular region] (Rattus norvegicus)

RBP4(19-201) [extracellular region] (Sus scrofa)

lpr-2 [extracellular region] (Caenorhabditis elegans)

Cross References

ZINC - World Drugs

RET4_HUMAN

Guide to Pharmacology - Targets

2549

OpenTargets

ENSG00000138207

ENSEMBL

ENSP00000360519, ENST00000371467, ENST00000371464, ENSP00000360522

ZINC - FDA approved

RET4_HUMAN

ZINC - Substances

RET4_HUMAN

ZINC - Biogenic

RET4_HUMAN

ZINC target

P02753

PRO

P02753

PDB

5NTY, 1QAB, 3FMZ, 1JYD, 5NUA, 1BRQ, 1RLB, 2WR6, 5NUB, 5NU6, 5NU7, 4PSQ, 2WQ9, 1JYJ, 2WQA, 3BSZ, 1BRP, 1RBP, 6QBA, 4O9S, 5NU2, 5NU9, 5NU8

ZINC - Investigational

RET4_HUMAN

ZINC - Metabolites

RET4_HUMAN

HPA

ENSG00000138207-RBP4

Pharos - Targets

P02753

Orphanet

RBP4

ZINC - Predictions - Purchasable

RET4_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.646	4
UniProt:Q9UBX0 HESX1			0.564	2
UniProt:O55245 TTHY			0.558	2
UniProt:Q6UW68 TM205			0.527	2
UniProt:P05423 POLR3D	2	POLR3D [nucleoplasm] (R-HSA-83704) POLR3D [cytosol] (R-HSA-1964429)	0.527	2
UniProt:P53673 CRBA4			0.527	2
UniProt:P49006 MRP			0.527	2
UniProt:P02794 FTH1	5	FTH1 [cytosol] (R-HSA-434212) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [extracellular region] (R-HSA-2187212) FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [endocytic vesicle lumen] (R-HSA-2299670)	0.527	2