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SUMF2 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-1614305
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Sulfatase-modifying factor 2, SUMF2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)
SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)
SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
The activation of arylsulfatases (Homo sapiens)
SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)
SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)
SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NBJ7 SUMF2
Gene Names
SUMF2, PSEC0171, UNQ1968/PRO4500
Chain
signal peptide:1-25, chain:26-301
Reference Genes
BioGPS Gene:25870 SUMF2
COSMIC (genes):SUMF2 SUMF2
CTD Gene:25870 SUMF2
dbSNP Gene:25870 SUMF2
ENSEMBL:ENSG00000129103 SUMF2
ENSEMBL_homo_sapiens_GENE:ENSG00000129103.19 SUMF2
HGNC:20415 SUMF2
KEGG Gene (Homo sapiens):25870 SUMF2
Monarch:25870 SUMF2
NCBI Gene:25870 SUMF2
OMIM:607940 SUMF2
UCSC:Q8NBJ7 SUMF2
Reference Transcript
RefSeq:NM_001130069.2 SUMF2
RefSeq:NM_001146333.1 SUMF2
RefSeq:NM_015411.2 SUMF2
RefSeq:NM_001042470.1 SUMF2
RefSeq:NM_001042469.1 SUMF2
Other Identifiers
11725026_a_at
11734411_x_at
11741066_a_at
11741067_x_at
11741689_s_at
11741690_x_at
11748021_x_at
17046284
225002_PM_s_at
225002_s_at
25870
3003229
3003230
3003231
3003233
3003236
3003241
3003242
3003243
3003245
3003246
3003247
3003250
3003251
3003253
3003254
3003255
3003256
3003257
3003258
48704_at
8132964
A_14_P133827
A_23_P123265
GE56232
GO:0005515
GO:0005783
GO:0005788
GO:0042802
GO:0043226
GO:0046872
HMNXSV003042878
HMNXSV003048583
Hs.78605.0.S1_3p_a_at
ILMN_1685371
ILMN_2345872
PH_hs_0014382
TC07000341.hg
Participates
as an input of
SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)
as a component of
SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)
Inferred To
Sumf2 [endoplasmic reticulum lumen]
(Rattus norvegicus)
SUMF2 [endoplasmic reticulum lumen]
(Bos taurus)
SUMF2 [endoplasmic reticulum lumen]
(Canis familiaris)
SUMF2 [endoplasmic reticulum lumen]
(Gallus gallus)
SUMF2 [endoplasmic reticulum lumen]
(Mus musculus)
SUMF2 [endoplasmic reticulum lumen]
(Sus scrofa)
Cross References
RefSeq
NP_001123541.1
,
NP_001035934.2
,
NP_056226.2
,
NP_001035935.2
,
NP_001139805.1
OpenTargets
ENSG00000129103
GeneCards
Q8NBJ7
HPA
ENSG00000129103-SUMF2
Ensembl
ENST00000434526
,
ENST00000395435
,
ENSG00000129103
,
ENSP00000275607
,
ENSP00000400922
,
ENSP00000378823
,
ENSP00000341938
,
ENST00000275607
,
ENST00000342190
PRO
Q8NBJ7
Pharos - Targets
Q8NBJ7
PDB
1Y4J
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.659
3
UniProt:Q8NBK3 SUMF1
1
SUMF1 [endoplasmic reticulum lumen]
(R-HSA-1614316)
0.637
9
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P07339 CTSD
12
CTSD(65-161) [lysosomal lumen]
(R-HSA-9023739)
CTSD(65-412) [extracellular region]
(R-HSA-2990853)
CTSD(65-412) [plasma membrane]
(R-HSA-2990852)
CTSD(65-412) [tertiary granule lumen]
(R-HSA-6801276)
CTSD(65-412) [ficolin-1-rich granule lumen]
(R-HSA-6801321)
CTSD(65-412) [specific granule lumen]
(R-HSA-6801272)
CTSD(169-412) [endosome lumen]
(R-HSA-9816128)
CTSD(65-161) [endosome lumen]
(R-HSA-9816123)
CTSD(169-412) [extracellular region]
(R-HSA-2471614)
CTSD(65-161) [extracellular region]
(R-HSA-2228718)
CTSD(65-412) [lysosomal lumen]
(R-HSA-1181223)
CTSD(169-412) [lysosomal lumen]
(R-HSA-9023737)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:P22304 IDS
6
IDS (456-550) R468L [lysosomal lumen]
(R-HSA-2210364)
IDS (34-455) R443* [lysosomal lumen]
(R-HSA-2210360)
IDS (456-550) R468W [lysosomal lumen]
(R-HSA-2210368)
IDS (456-550) R468Q [lysosomal lumen]
(R-HSA-2457604)
IDS(34-455) [lysosomal lumen]
(R-HSA-1678626)
IDS(456-550) [lysosomal lumen]
(R-HSA-1678681)
0.499
2
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