Reactome | NPC2 [azurophil granule lumen]

NPC2 [azurophil granule lumen]

Stable Identifier

R-HSA-6799163

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Epididymal secretory protein E1, NPC2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P61916 NPC2

Gene Names

NPC2, HE1

Chain

signal peptide:1-19, chain:20-151

Reference Genes

BioGPS Gene:10577 NPC2

COSMIC (genes):NPC2 NPC2

CTD Gene:10577 NPC2

dbSNP Gene:10577 NPC2

ENSEMBL:ENSG00000119655 NPC2

ENSEMBL_homo_sapiens_GENE:ENSG00000119655.11 NPC2

HGNC:14537 NPC2

KEGG Gene (Homo sapiens):10577 NPC2

Monarch:10577 NPC2

NCBI Gene:10577 NPC2

OMIM:601015 NPC2

UCSC:P61916 NPC2

Reference Transcript

RefSeq:NM_006432.3 NPC2

Other Identifiers

10577

11716828_a_at

11745902_a_at

11760369_at

16794705

200701_PM_at

200701_at

3571928

3571929

3571931

3571934

3571935

3571936

3571937

39345_at

7980146

A_23_P48717

GE59939

GO:0005215

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0006629

GO:0006869

GO:0008202

GO:0008203

GO:0008289

GO:0009615

GO:0010467

GO:0010878

GO:0015485

GO:0015914

GO:0015918

GO:0016125

GO:0019747

GO:0019899

GO:0030301

GO:0031410

GO:0032366

GO:0032367

GO:0032934

GO:0033344

GO:0035578

GO:0042632

GO:0043202

GO:0043226

GO:0046836

GO:0061024

GO:0070062

GO:0120009

GO:0120020

HMNXSV003030013

ILMN_1716678

PH_hs_0020101

PH_hs_0033319

TC14001307.hg

X67698_at

g5453677_3p_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

NPC2 [lysosomal lumen]

NPC2 [extracellular region]

Inferred To

LOC119876012 [azurophil granule lumen] (Canis familiaris)

npc2 [azurophil granule lumen] (Danio rerio)

npc2 [azurophil granule lumen] (Schizosaccharomyces pombe)

npc2 [azurophil granule lumen] (Xenopus tropicalis)

Homologues of NPC2 [azurophil granule lumen] (Canis familiaris)

Homologues of NPC2 [azurophil granule lumen] (Danio rerio)

Homologues of NPC2 [azurophil granule lumen] (Dictyostelium discoideum)

Npc2a [azurophil granule lumen] (Drosophila melanogaster)

ctnC [azurophil granule lumen] (Dictyostelium discoideum)

heh-1 [azurophil granule lumen] (Caenorhabditis elegans)

Npc2 [azurophil granule lumen] (Mus musculus)

Npc2 [azurophil granule lumen] (Rattus norvegicus)

npc2.2 [azurophil granule lumen] (Danio rerio)

NPC2 [azurophil granule lumen] (Bos taurus)

NPC2 [azurophil granule lumen] (Canis familiaris)

NPC2 [azurophil granule lumen] (Dictyostelium discoideum)

NPC2 [azurophil granule lumen] (Gallus gallus)

NPC2 [azurophil granule lumen] (Saccharomyces cerevisiae)

NPC2 [azurophil granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_006423.1

OpenTargets

ENSG00000119655

HPA

ENSG00000119655-NPC2

GeneCards

P61916

Ensembl

ENST00000541064, ENST00000555619, ENSG00000119655, ENSP00000442488, ENSP00000451112

PRO

P61916

Pharos - Targets

P61916

Orphanet

16562

HMDB Protein

HMDBP02675

PDB

6W5V, 5KWY

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
cholesterol [ChEBI:16113]	20	CHOL [lipid droplet] (R-ALL-163586) CHOL [early endosome] (R-ALL-2429660) CHOL [mitochondrial matrix] (R-ALL-193840) CHOL [cornified envelope] (R-ALL-8847704) cholesterol [mitochondrial intermembrane space] (R-ALL-196084) CHOL [mitochondrial outer membrane] (R-ALL-8951853) CHOL [mitochondrial inner membrane] (R-ALL-193156) CHOL [lysosomal membrane] (R-ALL-8876478) cholesterol [endosome lumen] (R-ALL-171083) cholesterol [endosome membrane] (R-ALL-171135) cholesterol [clathrin-coated endocytic vesicle membrane] (R-ALL-171069) CHOL [endoplasmic reticulum lumen] (R-ALL-174672) CHOL [smooth endoplasmic reticulum] (R-ALL-8866305) CHOL [transport vesicle membrane] (R-ALL-216762) CHOL [lysosomal lumen] (R-ALL-8848047) CHOL [cytosol] (R-ALL-176478) cholesterol [endocytic vesicle lumen] (R-ALL-2239405) CHOL [plasma membrane] (R-ALL-171095) CHOL [endoplasmic reticulum membrane] (R-ALL-193384) CHOL [extracellular region] (R-ALL-171149)	0.783	6
UniProt:O15118 NPC1	1	NPC1 [lysosomal membrane] (R-HSA-5216153)	0.667	3
UniProt:Q7Z3B1 NEGR1	2	cleaved GPI-NEGR1 [extracellular region] (R-HSA-8941102) GPI-NEGR1 [plasma membrane] (R-HSA-8940719)	0.639	9
UniProt:P00751 CFB	4	CFB(26-259) [extracellular region] (R-HSA-173744) CFB(26-764) [extracellular region] (R-HSA-173738) CFB(260-764) [plasma membrane] (R-HSA-173746) CFB(260-764) [extracellular region] (R-HSA-182453)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [extracellular region] (R-HSA-1462022) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215)	0.527	2
UniProt:P52790 HK3	4	HK3 [secretory granule lumen] (R-HSA-6801511) HK3 [extracellular region] (R-HSA-6806457) HK3 [ficolin-1-rich granule lumen] (R-HSA-6801527) HK3 [cytosol] (R-HSA-70412)	0.527	2
UniProt:Q7L523 RRAGA	2	K63polyUb-K142,K220,K230,K244-RRAGA [cytosol] (R-HSA-8938830) RRAGA [cytosol] (R-HSA-5653577)	0.527	2
UniProt:Q8WZA9 IRGQ			0.527	2
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.527	2
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.527	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2

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