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NPC2 [extracellular region]
Stable Identifier
R-HSA-6806224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Epididymal secretory protein E1, NPC2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
NPC2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61916 NPC2
Gene Names
NPC2, HE1
Chain
signal peptide:1-19, chain:20-151
Reference Genes
BioGPS Gene:10577 NPC2
COSMIC (genes):NPC2 NPC2
CTD Gene:10577 NPC2
dbSNP Gene:10577 NPC2
ENSEMBL:ENSG00000119655 NPC2
ENSEMBL_homo_sapiens_GENE:ENSG00000119655.11 NPC2
HGNC:14537 NPC2
KEGG Gene (Homo sapiens):10577 NPC2
Monarch:10577 NPC2
NCBI Gene:10577 NPC2
OMIM:601015 NPC2
UCSC:P61916 NPC2
Reference Transcript
RefSeq:NM_006432.3 NPC2
Other Identifiers
10577
11716828_a_at
11745902_a_at
11760369_at
16794705
200701_PM_at
200701_at
3571928
3571929
3571931
3571934
3571935
3571936
3571937
39345_at
7980146
A_23_P48717
GE59939
GO:0005215
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005783
GO:0006629
GO:0006869
GO:0008202
GO:0008203
GO:0008289
GO:0009615
GO:0010467
GO:0010878
GO:0015485
GO:0015914
GO:0015918
GO:0016125
GO:0019747
GO:0019899
GO:0030301
GO:0031410
GO:0032366
GO:0032367
GO:0032934
GO:0033344
GO:0035578
GO:0042632
GO:0043202
GO:0043226
GO:0046836
GO:0061024
GO:0070062
GO:0120009
GO:0120020
HMNXSV003030013
ILMN_1716678
PH_hs_0020101
PH_hs_0033319
TC14001307.hg
X67698_at
g5453677_3p_at
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
NPC2 [lysosomal lumen]
NPC2 [azurophil granule lumen]
Inferred To
NPC2 [extracellular region]
(Bos taurus)
NPC2 [extracellular region]
(Canis familiaris)
NPC2 [extracellular region]
(Dictyostelium discoideum)
NPC2 [extracellular region]
(Gallus gallus)
NPC2 [extracellular region]
(Saccharomyces cerevisiae)
NPC2 [extracellular region]
(Sus scrofa)
ctnC [extracellular region]
(Dictyostelium discoideum)
Homologues of NPC2 [extracellular region]
(Canis familiaris)
Homologues of NPC2 [extracellular region]
(Danio rerio)
Homologues of NPC2 [extracellular region]
(Dictyostelium discoideum)
npc2.2 [extracellular region]
(Danio rerio)
Npc2a [extracellular region]
(Drosophila melanogaster)
heh-1 [extracellular region]
(Caenorhabditis elegans)
npc2 [extracellular region]
(Danio rerio)
npc2 [extracellular region]
(Schizosaccharomyces pombe)
npc2 [extracellular region]
(Xenopus tropicalis)
LOC119876012 [extracellular region]
(Canis familiaris)
Npc2 [extracellular region]
(Mus musculus)
Npc2 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_006423.1
OpenTargets
ENSG00000119655
HPA
ENSG00000119655-NPC2
GeneCards
P61916
Ensembl
ENST00000541064
,
ENST00000555619
,
ENSG00000119655
,
ENSP00000442488
,
ENSP00000451112
PRO
P61916
Pharos - Targets
P61916
Orphanet
16562
HMDB Protein
HMDBP02675
PDB
6W5V
,
5KWY
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
cholesterol [ChEBI:16113]
20
CHOL [lipid droplet]
(R-ALL-163586)
CHOL [early endosome]
(R-ALL-2429660)
CHOL [mitochondrial matrix]
(R-ALL-193840)
CHOL [cornified envelope]
(R-ALL-8847704)
cholesterol [mitochondrial intermembrane space]
(R-ALL-196084)
CHOL [mitochondrial outer membrane]
(R-ALL-8951853)
CHOL [mitochondrial inner membrane]
(R-ALL-193156)
CHOL [lysosomal membrane]
(R-ALL-8876478)
cholesterol [endosome lumen]
(R-ALL-171083)
cholesterol [endosome membrane]
(R-ALL-171135)
cholesterol [clathrin-coated endocytic vesicle membrane]
(R-ALL-171069)
CHOL [endoplasmic reticulum lumen]
(R-ALL-174672)
CHOL [smooth endoplasmic reticulum]
(R-ALL-8866305)
CHOL [transport vesicle membrane]
(R-ALL-216762)
CHOL [lysosomal lumen]
(R-ALL-8848047)
CHOL [cytosol]
(R-ALL-176478)
cholesterol [endocytic vesicle lumen]
(R-ALL-2239405)
CHOL [plasma membrane]
(R-ALL-171095)
CHOL [endoplasmic reticulum membrane]
(R-ALL-193384)
CHOL [extracellular region]
(R-ALL-171149)
0.783
6
UniProt:O15118 NPC1
1
NPC1 [lysosomal membrane]
(R-HSA-5216153)
0.667
3
UniProt:Q7Z3B1 NEGR1
2
cleaved GPI-NEGR1 [extracellular region]
(R-HSA-8941102)
GPI-NEGR1 [plasma membrane]
(R-HSA-8940719)
0.639
9
UniProt:P00751 CFB
4
CFB(26-259) [extracellular region]
(R-HSA-173744)
CFB(26-764) [extracellular region]
(R-HSA-173738)
CFB(260-764) [plasma membrane]
(R-HSA-173746)
CFB(260-764) [extracellular region]
(R-HSA-182453)
0.527
2
UniProt:P59665 DEFA1
9
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
0.527
2
UniProt:P52790 HK3
4
HK3 [secretory granule lumen]
(R-HSA-6801511)
HK3 [extracellular region]
(R-HSA-6806457)
HK3 [ficolin-1-rich granule lumen]
(R-HSA-6801527)
HK3 [cytosol]
(R-HSA-70412)
0.527
2
UniProt:Q7L523 RRAGA
2
K63polyUb-K142,K220,K230,K244-RRAGA [cytosol]
(R-HSA-8938830)
RRAGA [cytosol]
(R-HSA-5653577)
0.527
2
UniProt:Q8WZA9 IRGQ
0.527
2
UniProt:O60361 NME2P1
1
NME2P1 [cytosol]
(R-HSA-6806876)
0.527
2
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.527
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.527
2
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