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TP73 [nucleoplasm]
Stable Identifier
R-HSA-6798094
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Tumor protein p73
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
TP53 binds PPP1R13L (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
TP53 family members bind the CASP1 gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate CASP1 expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
TP53 family members bind the FAS gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate FAS gene expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 family members bind the BAX promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate BAX transcription (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
TP73 tetramer translocates to the nucleus (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
YAP1 binds TP73 (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
p-Y407-YAP1:TP73 tetramer [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
TP73 Tetramer [nucleoplasm] (Homo sapiens)
TP73 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15350 TP73
Gene Names
TP73, P73
Chain
chain:1-636
Reference Genes
COSMIC (genes):TP73 TP73
ENSEMBL:ENSG00000078900 TP73
Participates
as a component of
TP73 Tetramer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PolyUb-TP73 [cytosol]
TP73 [cytosol]
Inferred To
TP73 [nucleoplasm]
(Bos taurus)
TP73 [nucleoplasm]
(Danio rerio)
TP73 [nucleoplasm]
(Drosophila melanogaster)
TP73 [nucleoplasm]
(Gallus gallus)
TP73 [nucleoplasm]
(Mus musculus)
TP73 [nucleoplasm]
(Rattus norvegicus)
TP73 [nucleoplasm]
(Sus scrofa)
TP73 [nucleoplasm]
(Xenopus tropicalis)
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.75
5
UniProt:P46937 YAP1
8
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
0.73
5
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.653
3
UniProt:Q9NZC7 WWOX
1
WWOX [cytosol]
(R-HSA-1253335)
0.641
4
UniProt:P38646 HSPA9
6
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [cytosol]
(R-HSA-5251993)
0.637
11
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.632
11
UniProt:P46934 NEDD4
1
NEDD4 [cytosol]
(R-HSA-975992)
0.623
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.602
4
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.558
4
UniProt:Q9ESJ1 Cables1
3
Cables1 [nucleoplasm]
(R-MMU-1013861)
Cables1 [cytosol]
(R-MMU-1013843)
Cables1 [nucleoplasm]
(R-MMU-1013870)
0.482
3
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