Reactome | TP73 [nucleoplasm]

TP73 [nucleoplasm]

Stable Identifier

R-HSA-6798094

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Tumor protein p73

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds PPP1R13L (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        TP53 family members bind the CASP1 gene (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 family members stimulate CASP1 expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members bind the FAS gene (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 family members bind the BAX promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 family members stimulate BAX transcription (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        TP73 tetramer translocates to the nucleus (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        YAP1 binds TP73 (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        p-Y407-YAP1:TP73 tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of PUMA and translocation to mitochondria (Homo sapiens)
        
        TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        p-S15,S20-TP53,TP63,TP73 [nucleoplasm] (Homo sapiens)
        
        TP73 Tetramer [nucleoplasm] (Homo sapiens)
        
        TP73 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15350 TP73

Gene Names

TP73, P73

Chain

chain:1-636

Reference Genes

BioGPS Gene:7161 TP73

COSMIC (genes):TP73 TP73

CTD Gene:7161 TP73

dbSNP Gene:7161 TP73

ENSEMBL:ENSG00000078900 TP73

ENSEMBL:ENSG00000078900.15 TP73

HGNC:12003 TP73

KEGG Gene (Homo sapiens):7161 TP73

Monarch:7161 TP73

NCBI Gene:7161 TP73

OMIM:601990 TP73

UCSC:O15350 TP73

Reference Transcript

Other Identifiers

11736821_x_at

11736822_a_at

11738188_a_at

11738189_x_at

11738527_x_at

11751371_a_at

11751372_x_at

11752787_a_at

11756355_a_at

1554379_PM_a_at

1554379_a_at

16658192

220804_PM_s_at

220804_s_at

2317348

2317349

2317356

2317357

2317358

2317365

2317366

2317367

2317368

2317369

2317370

2317380

2317381

2317387

2317388

2317389

2317391

2317392

2317393

2317394

2317396

2317397

2317399

2317400

2317401

2317402

2317403

2317404

2317405

2317406

2317407

2317460

2317461

2317462

2317463

2317465

2317466

2317468

232546_PM_at

232546_at

7161

7897179

A_14_P123511

A_14_P134062

A_23_P74081

A_24_P413470

A_33_P3296831

GE61233

GO:0000278

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001222

GO:0001228

GO:0001822

GO:0002039

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0005829

GO:0006281

GO:0006298

GO:0006351

GO:0006355

GO:0006357

GO:0006915

GO:0006974

GO:0007049

GO:0007346

GO:0008285

GO:0008630

GO:0009410

GO:0010243

GO:0010468

GO:0012501

GO:0019901

GO:0023052

GO:0030054

GO:0030154

GO:0042771

GO:0042802

GO:0043065

GO:0043226

GO:0043231

GO:0043410

GO:0043565

GO:0045665

GO:0045893

GO:0045944

GO:0046872

GO:0048714

GO:0048856

GO:0051262

GO:0051726

GO:0060044

GO:0061629

GO:0065003

GO:0097371

GO:0140110

GO:0140297

GO:1901248

HMNXSV003017681

Hs.247753.1.S1_3p_at

ILMN_1778188

PH_hs_0022923

TC01000071.hg

Y11416_at

g4885644_3p_s_at

Participates

as a component of

TP73 Tetramer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PolyUb-TP73 [cytosol]

TP73 [cytosol]

Inferred To

TP73 [nucleoplasm] (Bos taurus)

TP73 [nucleoplasm] (Canis familiaris)

TP73 [nucleoplasm] (Danio rerio)

TP73 [nucleoplasm] (Drosophila melanogaster)

TP73 [nucleoplasm] (Gallus gallus)

TP73 [nucleoplasm] (Mus musculus)

TP73 [nucleoplasm] (Rattus norvegicus)

TP73 [nucleoplasm] (Sus scrofa)

TP73 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001191119.1, NP_001191114.1, NP_001191116.1, NP_001191120.1, NP_001119712.1, NP_001191115.1, NP_001119713.1, NP_005418.1, NP_001191121.1, NP_001191118.1, NP_001119714.1, NP_001191117.1, NP_001191113.1

OpenTargets

ENSG00000078900

HPA

ENSG00000078900-TP73

GeneCards

O15350

Ensembl

ENST00000346387, ENSP00000350366, ENST00000603362, ENSP00000367545, ENSP00000340740, ENSP00000367537, ENST00000604074, ENSP00000367534, ENST00000604479, ENSP00000367539, ENSG00000078900, ENST00000357733, ENST00000354437, ENST00000378288, ENSP00000474322, ENSP00000475143, ENST00000378290, ENST00000378285, ENSP00000346423, ENST00000378295, ENSP00000474626

PRO

O15350

Pharos - Targets

O15350

Orphanet

23400

PDB

6IJQ, 5HOB, 4G83, 1COK, 3VD2, 1DXS, 2WQI, 4A63, 2WTT, 6FGS, 3VD0, 4GUQ, 2MPS, 7EZJ, 2XWC, 2NB1, 2WQJ, 2KBY, 4G82, 4GUO, 3VD1, 5HOC, 5KBD

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96J02 ITCH	2	Ub-C871-ITCH [cytosol] (R-HSA-8864515) ITCH [cytosol] (R-HSA-975995)	0.75	5
UniProt:P46937 YAP1	7	p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.73	5
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.653	3
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.637	11
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.632	11
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.623	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.558	4
UniProt:Q9ESJ1 Cables1	3	Cables1 [nucleoplasm] (R-MMU-1013861) Cables1 [cytosol] (R-MMU-1013843) Cables1 [nucleoplasm] (R-MMU-1013870)	0.482	3

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