Reactome | TP73 [cytosol]

TP73 [cytosol]

Stable Identifier

R-HSA-8957239

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tumor protein p73

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15350 TP73

Gene Names

TP73, P73

Chain

chain:1-636

Reference Genes

COSMIC (genes):TP73 TP73

ENSEMBL:ENSG00000078900 TP73

Participates

as a component of

TP73 Tetramer [cytosol] (Homo sapiens)

Other forms of this molecule

PolyUb-TP73 [cytosol]

TP73 [nucleoplasm]

Inferred To

TP73 [cytosol] (Bos taurus)

TP73 [cytosol] (Danio rerio)

TP73 [cytosol] (Drosophila melanogaster)

TP73 [cytosol] (Gallus gallus)

TP73 [cytosol] (Mus musculus)

TP73 [cytosol] (Rattus norvegicus)

TP73 [cytosol] (Sus scrofa)

TP73 [cytosol] (Xenopus tropicalis)

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96J02 ITCH	2	Ub-C871-ITCH [cytosol] (R-HSA-8864515) ITCH [cytosol] (R-HSA-975995)	0.75	5
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.73	5
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.653	3
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.641	4
UniProt:P38646 HSPA9	6	HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.637	11
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.632	11
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.623	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.558	4
UniProt:Q9ESJ1 Cables1	3	Cables1 [nucleoplasm] (R-MMU-1013861) Cables1 [cytosol] (R-MMU-1013843) Cables1 [nucleoplasm] (R-MMU-1013870)	0.482	3

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