Reactome | WIPF2 [cytosol]

WIPF2

Stable Identifier

R-HSA-2197666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

WAS/WASL-interacting protein family member 2, WIPF2_HUMAN, WICH, WIRE

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Activation of WASP/N-WASP by WIP family and SH3 domain proteins (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - Phosphorylation of WASP/N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases (Homo sapiens)
  - RHO GTPase Effectors (Homo sapiens)
    - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
      - Activation of WASP/N-WASP by WIP family and SH3 domain proteins (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - Phosphorylation of WASP/N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Homo sapiens)
        
        WIP family proteins [cytosol] (Homo sapiens)
        
        WIPF2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TF74 WIPF2

Gene Names

WIPF2, WICH, WIRE, PP10631

Chain

chain:1-440

Reference Genes

BioGPS Gene:147179 WIPF2

COSMIC (genes):WIPF2 WIPF2

CTD Gene:147179 WIPF2

dbSNP Gene:147179 WIPF2

ENSEMBL:ENSG00000171475 WIPF2

HGNC:30923 WIPF2

KEGG Gene (Homo sapiens):hsa:147179 WIPF2

Monarch:147179 WIPF2

NCBI Gene:147179 WIPF2

OMIM:609692 WIPF2

UCSC:Q8TF74 WIPF2

Reference Transcript

Other Identifiers

0004150050

11720975_a_at

11720976_at

11749248_a_at

11756713_a_at

11758840_at

147179

16834045

212049_at

212050_at

212051_at

231251_at

24000

24001

24467

3720856

3720867

3720868

3720870

3720871

3720875

3720879

3720880

3720881

3720882

3720883

3720884

3720885

3720886

40787_at

48933_at

8007058

83787_at

A8MWR2

A_23_P136325

A_23_P366455

A_24_P838748

A_33_P3274304

CCDS11364

ENSG00000171475

ENSP00000320924

ENSP00000462350

ENSP00000462826

ENST00000323571

ENST00000583130

ENST00000585043

EntrezGene:147179

GE518121

GE59552

GE84991

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0038096

HGNC:30923

HPA024000

HPA024001

HPA024467

Hs.13996.0.S1_3p_at

Hs.13996.0.S2_3p_at

Hs.13996.0.S3_3p_at

Hs.157716.0.A1_3p_at

ILMN_1775171

ILMN_1786229

MIM:609692

NM_133264

NP_573571

PF02205

PH_hs_0025147

SM00246

TC17000493.hg

U90911_at

uc002hug.2

uc002hui.2

uc010cwy.2

UPI000004D250

WIPF2

WIPF2-201

WIPF2-207

WIPF2-210

XM_005257083

XM_005257084

XM_011524412

XM_011524413

XP_005257140

XP_005257141

XP_011522714

XP_011522715

Participant Of

hasMember

WIP family proteins [cytosol]

Inferred To

Homologues of WIPF2 [cytosol] (Canis familiaris)

Homologues of WIPF2 [cytosol] (Danio rerio)

WIPF2 [cytosol] (Bos taurus)

WIPF2 [cytosol] (Canis familiaris)

WIPF2 [cytosol] (Danio rerio)

WIPF2 [cytosol] (Gallus gallus)

WIPF2 [cytosol] (Mus musculus)

WIPF2 [cytosol] (Rattus norvegicus)

WIPF2 [cytosol] (Sus scrofa)

WIPF2 [cytosol] (Taeniopygia guttata)

WIPF2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_573571.1, XP_011522715.1, XP_005257141.1, XP_005257140.1

GeneCards

Q8TF74

PRO

Q8TF74

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.667	3
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.621	3