Reactome | ARP3 [cytosol]

ARP3 [cytosol]

Stable Identifier

R-BTA-419940

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

Actin-related protein 3, ACTR3, ARP3_BOVIN, ACTR3

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Nervous system development (Bos taurus)
  - Axon guidance (Bos taurus)
    - EPH-Ephrin signaling (Bos taurus)
      - EPHB-mediated forward signaling (Bos taurus)
        
        N-WASP binds ARP2/3 and G-actin (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - Branching and elongation of mother and daughter filaments (Bos taurus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - Detachment of WASP/WAVE (Bos taurus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)
        
        Actin filament bound Myosin-X [plasma membrane] (Bos taurus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
  - Signaling by Rho GTPases (Bos taurus)
    - RHO GTPase Effectors (Bos taurus)
      - RHO GTPases Activate WASPs and WAVEs (Bos taurus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Branching and elongation of mother and daughter filaments (Bos taurus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Detachment of WASP/WAVE (Bos taurus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        ARP2/3 complex [cytosol] (Bos taurus)
        
        ACTR3:ATP [cytosol] (Bos taurus)
        
        ARP3 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P61157 ACTR3

Gene Names

ACTR3, ARP3

Chain

initiator methionine:1, chain:2-418

Reference Genes

BioGPS Gene:281597 ACTR3

KEGG:bta:281597 ACTR3

Monarch:281597 ACTR3

NCBI Gene:281597 ACTR3

UCSC:P61157 ACTR3

Reference Transcript

RefSeq:NM_174226.2 ACTR3

Other Identifiers

281597

Bt.4292.1.S1_at

GO:0000910

GO:0005903

GO:0005911

GO:0007018

GO:0007163

GO:0008356

GO:0016344

GO:0022414

GO:0030027

GO:0033206

GO:0051321

GO:0051653

GO:0071346

Participates

as a component of

Inferred From

ACTR3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_776651.1

ENSEMBL

ENSBTAT00000070638, ENSBTAP00000066597, ENSBTAG00000003401

PRO

P61157

VGNC

50033

PDB

4XEI, 4JD2, 2P9L, 7TPT, 8TAH, 2P9K, 2P9P, 2P9N, 4XF2, 3RSE, 1K8K, 2P9I, 1TYQ, 2P9U, 2P9S, 3UKU, 6DEC, 9M5E, 3DXK, 1U2V, 3UKR, 3DXM, 9DLX, 9DLZ, 3ULE, 7T5Q, 7JPN, 9M64

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60598 Cttn	2	p-S113-Cttn [cytosol] (R-MMU-442839) Cttn [cytosol] (R-MMU-442836)	0.702	4
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.702	3

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