Reactome | PAK4 [cytosol]

PAK4 [cytosol]

Stable Identifier

R-HSA-428461

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase PAK 4, PAK4_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Activation of RAC1 (Homo sapiens)
        
        Recruitment of PAK to NCK (Homo sapiens)
        
        PAK [cytosol] (Homo sapiens)
        
        PAK4 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:NCK:PAK [plasma membrane] (Homo sapiens)
        
        PAK [cytosol] (Homo sapiens)
        
        PAK4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O96013 PAK4

Gene Names

PAK4, KIAA1142

Chain

chain:1-591

Reference Genes

BioGPS Gene:10298 PAK4

COSMIC (genes):PAK4 PAK4

CTD Gene:10298 PAK4

dbSNP Gene:10298 PAK4

ENSEMBL:ENSG00000130669 PAK4

HGNC:16059 PAK4

KEGG:hsa:10298 PAK4

Monarch:10298 PAK4

NCBI Gene:10298 PAK4

OMIM:605451 PAK4

UCSC:O96013 PAK4

Reference Transcript

Participates

as a candidate of

as a member of

Inferred To

Homologues of PAK4 [cytosol] (Dictyostelium discoideum)

Homologues of PAK4 [cytosol] (Saccharomyces cerevisiae)

Homologues of PAK4 [cytosol] (Schizosaccharomyces pombe)

PAK4 [cytosol] (Bos taurus)

PAK4 [cytosol] (Caenorhabditis elegans)

PAK4 [cytosol] (Canis familiaris)

PAK4 [cytosol] (Dictyostelium discoideum)

PAK4 [cytosol] (Drosophila melanogaster)

PAK4 [cytosol] (Mus musculus)

PAK4 [cytosol] (Rattus norvegicus)

PAK4 [cytosol] (Saccharomyces cerevisiae)

PAK4 [cytosol] (Schizosaccharomyces pombe)

PAK4 [cytosol] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

2136

OpenTargets

ENSG00000130669

ENSEMBL

ENSP00000326864, ENSG00000130669, ENSP00000471157, ENST00000599386, ENST00000599470, ENST00000321944, ENSP00000470284, ENST00000593690, ENST00000358301, ENST00000360442, ENSP00000353625, ENSP00000351049, ENSP00000469413

ZINC - FDA approved

PAK4_HUMAN

ZINC - Substances

PAK4_HUMAN

ZINC - Biogenic

PAK4_HUMAN

ZINC target

O96013

PRO

O96013

GlyGen

O96013

PDB

6WLX, 2BVA, 4APP, 5I0B, 4XBU, 4JDH, 4NJD, 7CP3, 4JDI, 6WLY, 4JDJ, 4JDK, 4FIJ, 8AHH, 7S46, 5UPL, 7CMB, 4FIE, 4O0X, 4XBR, 8AHG, 5XVA, 4FIF, 8AHI, 5XVG, 4O0Y, 7CP4, 2CDZ, 5BMS, 5ZJW, 4L67, 7S47, 2J0I, 4FIG, 2Q0N, 2X4Z, 4FIH, 5VEF, 7S48, 4FII, 5XVF, 8YHK, 4O0V, 2OV2, 5UPK, 5VED, 5VEE

ZINC - Investigational

PAK4_HUMAN

HPA

ENSG00000130669-PAK4

GeneCards

PAK4

Pharos - Targets

O96013

ZINC - Predictions - Purchasable

PAK4_HUMAN

HMDB Protein

HMDBP01267

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.916	10
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.88	9
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.825	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.763	10
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.628	5
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.619	8

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