Reactome | ADCY4 [plasma membrane]

ADCY4 [plasma membrane]

Stable Identifier

R-HSA-379054

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase type 4, ADCY4_HUMAN

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
      - G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Adenylate cyclase produces cAMP (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NFM4 ADCY4

Gene Names

ADCY4

Chain

chain:1-1077

Reference Genes

BioGPS Gene:196883 ADCY4

COSMIC (genes):ADCY4 ADCY4

CTD Gene:196883 ADCY4

dbSNP Gene:196883 ADCY4

ENSEMBL:ENSG00000129467 ADCY4

HGNC:235 ADCY4

KEGG:hsa:196883 ADCY4

Monarch:196883 ADCY4

NCBI Gene:196883 ADCY4

OMIM:600292 ADCY4

UCSC:Q8NFM4 ADCY4

Reference Transcript

Other Identifiers

11755003_a_at

16791319

196883

230800_PM_at

230800_at

3558167

3558169

3558170

3558171

3558172

3558173

3558174

3558175

3558176

3558177

3558178

3558179

3558180

3558181

3558183

3558184

3558185

3558186

3558187

3558188

3558189

3558190

3558191

3558192

3558193

3558194

3558195

3558196

3558197

3558198

3558200

3558201

3558202

3558203

3558204

3558206

3558207

3558208

3558209

3558210

3558211

3558212

3558213

3558214

3558215

3558216

3558217

3558218

3558219

3558220

3558221

3558223

3558224

3558225

54407_at

7978285

A_23_P381261

A_33_P3337161

GE88276

GO:0003824

GO:0004016

GO:0005080

GO:0005515

GO:0005524

GO:0005737

GO:0005886

GO:0006171

GO:0007188

GO:0007189

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0030425

GO:0035556

GO:0046872

GO:0055086

GO:1901135

HMNXSV003011637

Hs.58043.0.S1_3p_at

ILMN_2148944

PH_hs_0025898

TC14002316.hg

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Homo sapiens)

as a member of

Adenylate cyclase [plasma membrane] (Homo sapiens)

Inferred To

Ac76E [plasma membrane] (Drosophila melanogaster)

ACXA [plasma membrane] (Drosophila melanogaster)

Adcy4 [plasma membrane] (Mus musculus)

Adcy4 [plasma membrane] (Rattus norvegicus)

ACXB [plasma membrane] (Drosophila melanogaster)

Homologues of ADCY4 [plasma membrane] (Drosophila melanogaster)

ACXE [plasma membrane] (Drosophila melanogaster)

ACXC [plasma membrane] (Drosophila melanogaster)

acy-2 [plasma membrane] (Caenorhabditis elegans)

ADCY4 [plasma membrane] (Bos taurus)

ADCY4 [plasma membrane] (Canis familiaris)

ADCY4 [plasma membrane] (Sus scrofa)

ACXD [plasma membrane] (Drosophila melanogaster)

CG8970 [plasma membrane] (Drosophila melanogaster)

adcy4 [plasma membrane] (Xenopus tropicalis)

acaA [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_640340.2, NP_001185497.1, NP_001185521.1

Guide to Pharmacology - Targets

1281

ENSEMBL

ENSP00000312126, ENSP00000494977, ENSP00000495316, ENSP00000494454, ENSP00000452250, ENST00000642645, ENST00000554068, ENSP00000393177, ENST00000418030, ENSG00000284814, ENST00000310677, ENST00000646612, ENSG00000129467, ENST00000644961

OpenTargets

ENSG00000129467

GeneCards

ADCY4

HPA

ENSG00000129467-ADCY4

PRO

Q8NFM4

Pharos - Targets

Q8NFM4

GlyGen

Q8NFM4

HMDB Protein

HMDBP00705

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.556	3

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