Reactome | ADCY4 [plasma membrane]

ADCY4 [plasma membrane]

Stable Identifier

R-HSA-379054

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase type 4, ADCY4_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Adenylate cyclase produces cAMP (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NFM4 ADCY4

Gene Names

ADCY4

Chain

chain:1-1077

Reference Genes

BioGPS Gene:196883 ADCY4

COSMIC (genes):ADCY4 ADCY4

CTD Gene:196883 ADCY4

dbSNP Gene:196883 ADCY4

ENSEMBL:ENSG00000129467 ADCY4

ENSEMBL:ENSG00000284814 ADCY4

HGNC:235 ADCY4

KEGG Gene (Homo sapiens):196883 ADCY4

Monarch:196883 ADCY4

NCBI Gene:196883 ADCY4

OMIM:600292 ADCY4

UCSC:Q8NFM4 ADCY4

Reference Transcript

Other Identifiers

0002450133

11755003_a_at

16791319

196883

230800_at

3558170

3558171

3558172

3558174

3558177

3558178

3558180

3558184

3558186

3558189

3558191

3558193

3558194

3558196

3558198

3558200

3558201

3558202

3558204

3558206

3558207

3558209

3558211

3558213

3558216

3558218

3558221

3558223

3558224

3558225

54407_at

7978285

A_23_P381261

A_33_P3337161

GE88276

GO:0000166

GO:0002376

GO:0002862

GO:0003091

GO:0003674

GO:0004016

GO:0005080

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005887

GO:0006171

GO:0006464

GO:0006950

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007190

GO:0007193

GO:0008150

GO:0009058

GO:0009190

GO:0016020

GO:0016021

GO:0016829

GO:0016849

GO:0019899

GO:0030425

GO:0034199

GO:0034641

GO:0035556

GO:0042592

GO:0043167

GO:0044281

GO:0046872

GO:0071377

HMNXSV003011637

Hs.58043.0.S1_3p_at

ILMN_1677893

ILMN_2148944

PH_hs_0025898

TC14002316.hg

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Homo sapiens)

as a member of

Adenylate cyclase [plasma membrane] (Homo sapiens)

Inferred To

Ac76E [plasma membrane] (Drosophila melanogaster)

ACXA [plasma membrane] (Drosophila melanogaster)

Adcy4 [plasma membrane] (Mus musculus)

Adcy4 [plasma membrane] (Rattus norvegicus)

CG12436 [plasma membrane] (Drosophila melanogaster)

ACXB [plasma membrane] (Drosophila melanogaster)

Homologues of ADCY4 [plasma membrane] (Danio rerio)

Homologues of ADCY4 [plasma membrane] (Drosophila melanogaster)

acy-4 [plasma membrane] (Caenorhabditis elegans)

adcy2b [plasma membrane] (Danio rerio)

ACXE [plasma membrane] (Drosophila melanogaster)

ACXC [plasma membrane] (Drosophila melanogaster)

ADCY4 [plasma membrane] (Bos taurus)

ADCY4 [plasma membrane] (Canis familiaris)

ADCY4 [plasma membrane] (Sus scrofa)

ACXD [plasma membrane] (Drosophila melanogaster)

CG8970 [plasma membrane] (Drosophila melanogaster)

adcy4 [plasma membrane] (Xenopus tropicalis)

adcy2a [plasma membrane] (Danio rerio)

acaA [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001185521.1, NP_640340.2, NP_001185497.1

Guide to Pharmacology - Targets

1281

OpenTargets

ENSG00000129467

GeneCards

Q8NFM4

HPA

ENSG00000129467-ADCY4

Ensembl

ENST00000646612, ENSP00000495316, ENSG00000284814, ENSP00000452250, ENST00000644961, ENSG00000129467, ENST00000642645, ENSP00000494977, ENST00000418030, ENSP00000494454, ENSP00000393177, ENSP00000312126, ENST00000554068, ENST00000310677

PRO

Q8NFM4

Pharos - Targets

Q8NFM4

GlyGen

Q8NFM4

HMDB Protein

HMDBP00705

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) SUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.556	3

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