PIAS1,2-2 SUMOylate PPARG with SUMO1

Stable Identifier
R-HSA-4717461
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1,2-2 SUMOylate PPARG with SUMO1
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As inferred from mouse homologs, PIAS1,2-2 SUMOylate PPARG with SUMO1 at lysine-107 and lysine-395 (lysine-77 and lysine-365 of the shorter variant 1). SUMOylation decreases the transcriptional activation activity of PPARG. SUMOylation at lysine-395 is ligand-dependent and causes PPARG to recruit corepressors such as NCOR and HDAC3.
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Catalyst Activity

SUMO transferase activity of PIAS1,2-2 [nucleoplasm]

Physical Entity
PIAS1,2-2 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Pias1,2-2 Sumoylate Pparg with Sumo1 (Mus musculus)
Authored
May, B  (2013-10-11)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-18)
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