Reactome | RXRB [nucleoplasm]

RXRB [nucleoplasm]

Stable Identifier

R-HSA-446163

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Retinoic acid receptor RXR-beta, RXRB_HUMAN

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ABCA1 (Homo sapiens)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        NR1H2,3:RXR [nucleoplasm] (Homo sapiens)
        
        NR1H3:RXRB [nucleoplasm] (Homo sapiens)
        
        RXRB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28702 RXRB

Gene Names

RXRB, NR2B2

Chain

chain:1-533

Reference Genes

BioGPS Gene:6257 RXRB

COSMIC (genes):RXRB RXRB

CTD Gene:6257 RXRB

dbSNP Gene:6257 RXRB

ENSEMBL:ENSG00000204231 RXRB

HGNC:10478 RXRB

KEGG:hsa:6257 RXRB

Monarch:6257 RXRB

NCBI Gene:6257 RXRB

OMIM:180246 RXRB

UCSC:P28702 RXRB

Reference Transcript

Participates

as a component of

as a member of

NR [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of RXRB [nucleoplasm] (Caenorhabditis elegans)

Homologues of RXRB [nucleoplasm] (Xenopus tropicalis)

nhr-91 [nucleoplasm] (Caenorhabditis elegans)

nhr-148 [nucleoplasm] (Caenorhabditis elegans)

rxrba [nucleoplasm] (Danio rerio)

Rxrb [nucleoplasm] (Mus musculus)

Rxrb [nucleoplasm] (Rattus norvegicus)

nhr-207 [nucleoplasm] (Caenorhabditis elegans)

nhr-209 [nucleoplasm] (Caenorhabditis elegans)

nhr-60 [nucleoplasm] (Caenorhabditis elegans)

nhr-221 [nucleoplasm] (Caenorhabditis elegans)

nhr-154 [nucleoplasm] (Caenorhabditis elegans)

rxrb [nucleoplasm] (Xenopus tropicalis)

nhr-206 [nucleoplasm] (Caenorhabditis elegans)

nhr-129 [nucleoplasm] (Caenorhabditis elegans)

usp [nucleoplasm] (Drosophila melanogaster)

nhr-120 [nucleoplasm] (Caenorhabditis elegans)

nhr-137 [nucleoplasm] (Caenorhabditis elegans)

nhr-141 [nucleoplasm] (Caenorhabditis elegans)

nhr-116 [nucleoplasm] (Caenorhabditis elegans)

nhr-204 [nucleoplasm] (Caenorhabditis elegans)

nhr-208 [nucleoplasm] (Caenorhabditis elegans)

nhr-149 [nucleoplasm] (Caenorhabditis elegans)

nhr-147 [nucleoplasm] (Caenorhabditis elegans)

nhr-173 [nucleoplasm] (Caenorhabditis elegans)

nhr-36 [nucleoplasm] (Caenorhabditis elegans)

nhr-168 [nucleoplasm] (Caenorhabditis elegans)

nhr-152 [nucleoplasm] (Caenorhabditis elegans)

nhr-153 [nucleoplasm] (Caenorhabditis elegans)

RXRB [nucleoplasm] (Bos taurus)

RXRB [nucleoplasm] (Canis familiaris)

RXRB [nucleoplasm] (Sus scrofa)

nhr-93 [nucleoplasm] (Caenorhabditis elegans)

nhr-136 [nucleoplasm] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

611

OpenTargets

ENSG00000204231

ENSEMBL

ENST00000374685, ENST00000431820, ENSG00000227322, ENSG00000228333, ENSG00000206289, ENSP00000410468, ENST00000436753, ENSP00000415199, ENSP00000411238, ENST00000456244, ENST00000374680, ENSP00000402590, ENST00000431161, ENSP00000363817, ENST00000415157, ENSP00000363812, ENSP00000393286, ENSG00000235712, ENSP00000372703, ENSP00000372704, ENSP00000400104, ENST00000443603, ENST00000415909, ENSG00000204231, ENSP00000402506, ENST00000383217, ENST00000455462, ENSP00000393870, ENSG00000231321, ENST00000383216

ZINC - FDA approved

RXRB_HUMAN

ZINC - Substances

RXRB_HUMAN

ZINC - Biogenic

RXRB_HUMAN

ZINC target

P28702

PRO

P28702

GlyGen

P28702

PDB

1H9U, 5KYJ, 7A78, 5I4V, 5HJP, 1UHL, 5KYA

ZINC - Investigational

RXRB_HUMAN

ZINC - Metabolites

RXRB_HUMAN

HPA

ENSG00000204231-RXRB

GeneCards

RXRB

Pharos - Targets

P28702

ZINC - Predictions - Purchasable

RXRB_HUMAN

HMDB Protein

HMDBP01915

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.949	16
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.666	4
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.632	5
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3

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