Reactome | RXRB [nucleoplasm]

RXRB [nucleoplasm]

Stable Identifier

R-HSA-446163

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Retinoic acid receptor RXR-beta, RXRB_HUMAN

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Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ABCA1 (Homo sapiens)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        NR1H2,3:RXR [nucleoplasm] (Homo sapiens)
        
        NR1H3:RXRB [nucleoplasm] (Homo sapiens)
        
        RXRB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28702 RXRB

Gene Names

RXRB, NR2B2

Chain

chain:1-533

Reference Genes

BioGPS Gene:6257 RXRB

COSMIC (genes):RXRB RXRB

CTD Gene:6257 RXRB

dbSNP Gene:6257 RXRB

ENSEMBL:ENSG00000204231 RXRB

ENSEMBL:ENSG00000204231.11 RXRB

ENSEMBL:ENSG00000206289.11 RXRB

ENSEMBL:ENSG00000227322.11 RXRB

ENSEMBL:ENSG00000228333.9 RXRB

ENSEMBL:ENSG00000231321.9 RXRB

ENSEMBL:ENSG00000235712.10 RXRB

HGNC:10478 RXRB

KEGG Gene (Homo sapiens):6257 RXRB

Monarch:6257 RXRB

NCBI Gene:6257 RXRB

OMIM:180246 RXRB

UCSC:P28702 RXRB

Reference Transcript

Other Identifiers

11717208_at

11717209_s_at

11754991_a_at

1362_s_at

17018110

17029917

17032604

17034924

17037404

17040110

209148_PM_at

209148_at

215099_PM_s_at

215099_s_at

2950475

2950476

2950477

2950479

2950480

2950481

2950483

2950485

2950486

2950487

2950488

2950489

2950492

2950493

2950494

2950495

2950499

2950500

2950501

37763_at

6257

8125638

8178903

8180111

A_23_P59179

GE80083

GO:0000785

GO:0000977

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0008270

GO:0009755

GO:0016071

GO:0023052

GO:0030154

GO:0030501

GO:0032526

GO:0042789

GO:0043226

GO:0043401

GO:0043565

GO:0044323

GO:0045893

GO:0045944

GO:0046872

GO:0048384

GO:0048856

GO:0060089

GO:0070564

GO:0090575

GO:0140110

GO:1990837

HMNXSV003017698

HMNXSV003042760

Hs.79372.1.A1_3p_a_at

ILMN_1774074

M84820_s_at

PH_hs_0024444

TC06001580.hg

TC6_cox_hap2000204.hg

TC6_dbb_hap3000190.hg

TC6_mann_hap4000172.hg

TC6_mcf_hap5000179.hg

TC6_qbl_hap6000192.hg

X63522_s_at

X65463_at

g12654658_3p_at

Participates

as a component of

as a member of

NR [nucleoplasm] (Homo sapiens)

Inferred To

rxrb [nucleoplasm] (Xenopus tropicalis)

RXRB [nucleoplasm] (Bos taurus)

RXRB [nucleoplasm] (Canis familiaris)

RXRB [nucleoplasm] (Sus scrofa)

rxrba [nucleoplasm] (Danio rerio)

usp [nucleoplasm] (Drosophila melanogaster)

Rxrb [nucleoplasm] (Mus musculus)

Rxrb [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001257330.1, NP_068811.1

ZINC - World Drugs

RXRB_HUMAN

Guide to Pharmacology - Targets

611

OpenTargets

ENSG00000204231

ZINC - FDA approved

RXRB_HUMAN

ZINC - Substances

RXRB_HUMAN

ZINC - Biogenic

RXRB_HUMAN

ZINC target

P28702

PRO

P28702

PDB

7A78, 5KYA, 1UHL, 1H9U, 5KYJ, 5HJP, 5I4V

ZINC - Investigational

RXRB_HUMAN

ZINC - Metabolites

RXRB_HUMAN

HPA

ENSG00000204231-RXRB

GeneCards

P28702

Ensembl

ENST00000455462, ENSP00000393286, ENSG00000206289, ENSP00000400104, ENSP00000372704, ENSP00000372703, ENSP00000402590, ENSP00000410468, ENSP00000411238, ENSP00000363817, ENST00000415157, ENST00000456244, ENST00000415909, ENSG00000227322, ENSG00000228333, ENSP00000402506, ENST00000374680, ENST00000374685, ENSG00000204231, ENST00000431161, ENSG00000231321, ENST00000443603, ENSP00000393870, ENST00000383216, ENST00000431820, ENSP00000415199, ENSP00000363812, ENST00000436753, ENSG00000235712, ENST00000383217

Pharos - Targets

P28702

ZINC - Predictions - Purchasable

RXRB_HUMAN

HMDB Protein

HMDBP01915

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.949	16
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.632	5
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3

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