Reactome | CERS2 [endoplasmic reticulum membrane]

CERS2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428171

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LASS2, LAG1 homolog, ceramide synthase 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96G23 CERS2

Gene Names

CERS2, LASS2, TMSG1

Chain

chain:1-380

Reference Genes

BioGPS Gene:29956 CERS2

COSMIC (genes):CERS2 CERS2

CTD Gene:29956 CERS2

dbSNP Gene:29956 CERS2

ENSEMBL:ENSG00000143418 CERS2

HGNC:14076 CERS2

KEGG:hsa:29956 CERS2

Monarch:29956 CERS2

NCBI Gene:29956 CERS2

OMIM:606920 CERS2

UCSC:Q96G23 CERS2

Reference Transcript

Other Identifiers

11720200_s_at

11744724_a_at

16692892

222212_PM_s_at

222212_s_at

2434717

2434718

2434719

2434720

2434721

2434722

2434723

2434724

2434725

2434726

2434727

2434728

2434729

2434730

2434731

2434732

2434733

2434734

2434735

2434736

2434737

2434738

2434740

2434741

2434742

2434743

29956

56446_at

7919856

A_23_P63010

GE61615

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0010626

GO:0016020

GO:0016410

GO:0016740

GO:0019216

GO:0030148

GO:0035902

GO:0043226

GO:0046513

GO:0048681

GO:0050291

GO:1900148

GO:1905045

HMNXSV003044157

Hs.285976.2.S1_3p_a_at

ILMN_1726108

ILMN_2400500

PH_hs_0014794

TC01003215.hg

Participates

as a member of

Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

crsA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

LAG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

cers2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

schlank [endoplasmic reticulum membrane] (Drosophila melanogaster)

LAC1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

lag1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

cers2a [endoplasmic reticulum membrane] (Danio rerio)

CERS2 [endoplasmic reticulum membrane] (Bos taurus)

CERS2 [endoplasmic reticulum membrane] (Canis familiaris)

CERS2 [endoplasmic reticulum membrane] (Gallus gallus)

CERS2 [endoplasmic reticulum membrane] (Plasmodium falciparum)

CERS2 [endoplasmic reticulum membrane] (Sus scrofa)

Homologues of CERS2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Homologues of CERS2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of CERS2 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

lac1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cers2 [endoplasmic reticulum membrane] (Mus musculus)

Cers2 [endoplasmic reticulum membrane] (Rattus norvegicus)

hyl-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

hyl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

2475

ENSEMBL

ENST00000271688, ENST00000368954, ENSP00000357950, ENSP00000271688

OpenTargets

ENSG00000143418

HPA

ENSG00000143418-CERS2

PRO

Q96G23

Pharos - Targets

Q96G23

GlyGen

Q96G23

HMDB Protein

HMDBP11630

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.73	4
UniProt:O15245 SLC22A1	2	SLC22A1 [plasma membrane] (R-HSA-549126) SLC22A1 [basolateral plasma membrane] (R-HSA-9794526)	0.646	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.643	4
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:P25103 TACR1	2	TACR1 [plasma membrane] (R-HSA-380103) TACR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869122)	0.527	3
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.524	2
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	2

Cite Us!