Reactome | LPAR1 [plasma membrane]

LPAR1 [plasma membrane]

Stable Identifier

R-HSA-419354

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lysophosphatidic acid receptor 1, LPAR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LPA-binding receptors bind LPA (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92633 LPAR1

Gene Names

LPAR1, EDG2, LPA1

Chain

chain:1-364

Reference Genes

BioGPS Gene:1902 LPAR1

COSMIC (genes):LPAR1 LPAR1

CTD Gene:1902 LPAR1

dbSNP Gene:1902 LPAR1

ENSEMBL:ENSG00000198121 LPAR1

HGNC:3166 LPAR1

KEGG Gene (Homo sapiens):1902 LPAR1

Monarch:1902 LPAR1

NCBI Gene:1902 LPAR1

OMIM:602282 LPAR1

UCSC:Q92633 LPAR1

Reference Transcript

Other Identifiers

0005390707

11729750_a_at

11729751_a_at

11746409_a_at

11747839_a_at

17097132

1902

204036_at

204037_at

204038_s_at

3220385

3220386

3220387

3220388

3220389

3220390

3220391

3220411

3220414

3220415

3220416

3220417

3220422

3220435

3220436

40387_at

52170_at

77817_r_at

8163257

A_23_P502879

A_33_P3383326

GE59467

GE86272

GO:0000187

GO:0000902

GO:0001965

GO:0003674

GO:0004930

GO:0005515

GO:0005543

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0006464

GO:0007010

GO:0007165

GO:0007186

GO:0007189

GO:0007193

GO:0007202

GO:0007204

GO:0007420

GO:0008150

GO:0008219

GO:0008289

GO:0008360

GO:0009986

GO:0010942

GO:0010977

GO:0014003

GO:0016020

GO:0016021

GO:0019222

GO:0021549

GO:0021554

GO:0022008

GO:0022038

GO:0022607

GO:0030139

GO:0030154

GO:0030165

GO:0031410

GO:0032060

GO:0035025

GO:0035727

GO:0040011

GO:0042552

GO:0042592

GO:0043005

GO:0043025

GO:0043065

GO:0043123

GO:0043167

GO:0043197

GO:0043198

GO:0043226

GO:0043410

GO:0043951

GO:0048856

GO:0048870

GO:0051482

GO:0051496

GO:0060326

GO:0060999

GO:0070915

GO:0071453

GO:0071673

GO:1904566

HMNXSV003038033

Hs.75794.0.A3_3p_at

Hs.75794.0.A4_3p_at

ILMN_1674984

ILMN_1701441

PH_hs_0027687

TC09001478.hg

U80811_at

g4503456_3p_a_at

Participates

as a member of

LPAR1,2,3,5 [plasma membrane] (Homo sapiens)

Inferred To

lpar1 [plasma membrane] (Danio rerio)

Lpar1 [plasma membrane] (Mus musculus)

Lpar1 [plasma membrane] (Rattus norvegicus)

LPAR1 [plasma membrane] (Bos taurus)

LPAR1 [plasma membrane] (Canis familiaris)

LPAR1 [plasma membrane] (Gallus gallus)

LPAR1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_016869886.1, XP_016869894.1, XP_016869893.1, XP_016869882.1, XP_016869875.1, XP_016869879.1, XP_016869892.1, XP_016869885.1, XP_016869881.1, NP_001392.2, XP_016869874.1, XP_016869878.1, XP_016869889.1, XP_016869891.1, XP_016869888.1, XP_016869896.1, XP_016869884.1, XP_016869880.1, XP_016869873.1, NP_476500.1, XP_005251839.1, XP_016869877.1, XP_016869887.1, XP_016869890.1, XP_016869895.1, XP_016869883.1, XP_016869872.1, XP_005251838.1, XP_016869876.1

OpenTargets

ENSG00000198121

ZINC - Substances

LPAR1_HUMAN

ZINC - Biogenic

LPAR1_HUMAN

ZINC target

Q92633

PRO

Q92633

PDB

4Z34, 4Z36, 4Z35

ZINC - Investigational

LPAR1_HUMAN

ZINC - Metabolites

LPAR1_HUMAN

HPA

ENSG00000198121-LPAR1

GeneCards

Q92633

Ensembl

ENST00000374431, ENST00000374430, ENSP00000351755, ENST00000358883, ENSG00000198121, ENSP00000363553, ENSP00000363552

ZINC - Predictions - Purchasable

LPAR1_HUMAN

Orphanet

24681

HMDB Protein

HMDBP02852

Cite Us!