Reactome | LPAR1 [plasma membrane]

LPAR1 [plasma membrane]

Stable Identifier

R-HSA-419354

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lysophosphatidic acid receptor 1, LPAR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LPA-binding receptors bind LPA (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92633 LPAR1

Gene Names

LPAR1, EDG2, LPA1

Chain

chain:1-364

Reference Genes

BioGPS Gene:1902 LPAR1

COSMIC - genes:LPAR1 LPAR1

CTD Gene:1902 LPAR1

dbSNP Gene:1902 LPAR1

ENSEMBL:ENSG00000198121 LPAR1

HGNC:3166 LPAR1

KEGG:hsa:1902 LPAR1

Monarch:1902 LPAR1

NCBI Gene:1902 LPAR1

OMIM:602282 LPAR1

UCSC:Q92633 LPAR1

Reference Transcript

Other Identifiers

11729750_a_at

11729751_a_at

11746409_a_at

11747839_a_at

17097132

1902

204036_PM_at

204036_at

204037_PM_at

204037_at

204038_PM_s_at

204038_s_at

3220385

3220386

3220387

3220388

3220389

3220390

3220391

3220410

3220411

3220414

3220415

3220416

3220417

3220422

3220434

3220435

3220436

3220437

3220438

40387_at

52170_at

77817_r_at

8163257

A_23_P502879

A_33_P3383326

GE59467

GE86272

GO:0001965

GO:0004930

GO:0005515

GO:0005543

GO:0005737

GO:0005768

GO:0005886

GO:0007165

GO:0007186

GO:0007189

GO:0007193

GO:0007200

GO:0007204

GO:0008289

GO:0008360

GO:0009986

GO:0010977

GO:0014003

GO:0016020

GO:0016192

GO:0021549

GO:0021554

GO:0022008

GO:0022038

GO:0030139

GO:0030154

GO:0030165

GO:0031410

GO:0032060

GO:0035025

GO:0035727

GO:0042552

GO:0042734

GO:0043001

GO:0043025

GO:0043065

GO:0043123

GO:0043197

GO:0043198

GO:0043410

GO:0045211

GO:0045724

GO:0048856

GO:0048870

GO:0051496

GO:0060326

GO:0060627

GO:0060999

GO:0061512

GO:0070915

GO:0071453

GO:0071673

GO:0072659

GO:0098693

GO:0098978

GO:0098982

GO:0099149

GO:0141162

GO:1902018

GO:1904566

HMNXSV003038033

Hs.75794.0.A3_3p_at

Hs.75794.0.A4_3p_at

ILMN_1674984

ILMN_1701441

ILMN_1791242

PH_hs_0027687

TC09001478.hg

U80811_at

g4503456_3p_a_at

Participates

as a member of

LPAR1,2,3,5 [plasma membrane] (Homo sapiens)

Inferred To

lpar1 [plasma membrane] (Danio rerio)

lpar1 [plasma membrane] (Xenopus tropicalis)

LPAR1 [plasma membrane] (Bos taurus)

LPAR1 [plasma membrane] (Canis familiaris)

LPAR1 [plasma membrane] (Gallus gallus)

LPAR1 [plasma membrane] (Mus musculus)

LPAR1 [plasma membrane] (Rattus norvegicus)

LPAR1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001338332.1, XP_047278859.1, NP_001374440.1, NP_476500.1, NP_001338334.1, NP_001374418.1, NP_001374439.1, NP_001374410.1, NP_001338327.1, NP_001374414.1, NP_001374412.1, NP_001374431.1, NP_001374443.1, NP_001374403.1, NP_001338338.1, NP_001374401.1, NP_001338326.1, NP_001374424.1, NP_001374441.1, NP_001338328.1, NP_001338349.1, NP_001374411.1, NP_001374399.1, NP_001374419.1, NP_001374436.1, NP_001338345.1, NP_001374434.1, NP_001338342.1, NP_001338339.1, NP_001374417.1, NP_001374421.1, NP_001374425.1, NP_001374442.1, NP_001374400.1, NP_001338335.1, NP_001338329.1, NP_001374408.1, NP_001374406.1, NP_001392.2, NP_001338348.1, NP_001374433.1, NP_001374437.1, NP_001338346.1, NP_001374416.1, NP_001338330.1, NP_001374435.1, NP_001338341.1, NP_001338336.1, NP_001374409.1, NP_001374422.1, NP_001374426.1, NP_001374405.1, NP_001374407.1, NP_001374420.1, NP_001338331.1, NP_001338347.1, NP_001374415.1, NP_001374432.1, NP_001338343.1, NP_001374413.1, NP_001374430.1, NP_001374438.1, NP_001338337.1, NP_001374444.1, NP_001338344.1, NP_001374402.1, NP_001374404.1, NP_001338333.1, NP_001374423.1, NP_001374427.1, NP_001338340.1

Guide to Pharmacology - Targets

272

OpenTargets

ENSG00000198121

ENSEMBL

ENST00000358883, ENST00000683809, ENSG00000198121, ENSP00000363553, ENSP00000363552, ENST00000374430, ENSP00000506912, ENST00000374431, ENSP00000351755

ZINC - Substances

LPAR1_HUMAN

ZINC - Biogenic

LPAR1_HUMAN

ZINC target

Q92633

PRO

Q92633

GlyGen

Q92633

PDB

9J5V, 4Z35, 4Z34, 4Z36, 7YU8, 7YU7, 7YU6, 7YU3, 7YU5, 7TD1, 7TD2, 7TD0, 9IZF, 9IZG, 9IZH, 7YU4

ZINC - Investigational

LPAR1_HUMAN

ZINC - Metabolites

LPAR1_HUMAN

HPA

ENSG00000198121-LPAR1

GeneCards

LPAR1

Pharos - Targets

Q92633

ZINC - Predictions - Purchasable

LPAR1_HUMAN

HMDB Protein

HMDBP02852

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.643	3
UniProt:P21333 FLNA	3	FLNA [cytosol] (R-HSA-210019) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712)	0.584	8
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.527	3
UniProt:P48960 ADGRE5	2	CD97(21-835) [secretory granule membrane] (R-HSA-6803297) CD97 [plasma membrane] (R-HSA-444764)	0.527	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.527	2
UniProt:A0PJW6 TMEM223	1	TMEM223 [mitochondrial inner membrane] (R-HSA-9865797)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	3
UniProt:Q8N6M3 FITM2	1	FITM2 [endoplasmic reticulum membrane] (R-HSA-8857678)	0.527	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.527	2
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.527	2
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	2
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.527	2
UniProt:Q15800 MSMO1	1	MSMO1 [endoplasmic reticulum membrane] (R-HSA-194648)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	2
UniProt:O43909 EXTL3	2	EXTL3 [Golgi membrane] (R-HSA-9941179) EXTL3 [endoplasmic reticulum membrane] (R-HSA-535476)	0.527	2
UniProt:Q969V6 MRTFA	3	monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm] (R-HSA-3900216) MKL1 [nucleoplasm] (R-HSA-3900220) MKL1 [cytosol] (R-HSA-5665975)	0.504	5

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