Reactome | LPAR1 [plasma membrane]

LPAR1

Stable Identifier

R-HSA-419354

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lysophosphatidic acid receptor 1, LPAR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        GPCRs that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LPA-binding receptors bind LPA (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92633 LPAR1

Gene Names

LPAR1, EDG2, LPA1

Chain

chain:1-364

Reference Genes

BioGPS Gene:1902 LPAR1

COSMIC (genes):LPAR1 LPAR1

CTD Gene:1902 LPAR1

dbSNP Gene:1902 LPAR1

ENSEMBL:ENSG00000198121 LPAR1

HGNC:3166 LPAR1

KEGG Gene (Homo sapiens):hsa:1902 LPAR1

Monarch:1902 LPAR1

NCBI Gene:1902 LPAR1

OMIM:602282 LPAR1

UCSC:Q92633 LPAR1

Reference Transcript

Other Identifiers

0005390707

11729750_a_at

11729751_a_at

11746409_a_at

11747839_a_at

17097132

1902

204036_at

204037_at

204038_s_at

3220386

3220387

3220388

3220389

3220390

3220391

3220411

3220414

3220415

3220416

3220417

3220422

3220435

40387_at

4Z34

4Z35

4Z36

50667

52170_at

77817_r_at

8163257

A_23_P502879

A_33_P3383326

AAC00530

AAC51139

AAH30615

AAH36034

AAP84359

AC007157

AK022808

AK290287

AK296374

AL157881

AL442064

AY322546

BAF82976

BAG51118

BAG59048

BC030615

BC036034

CAA70686

CAA70687

CCDS6777

CH471105

EAW59068

EAW59069

ENSG00000198121

ENSP00000351755

ENSP00000363552

ENSP00000363553

ENST00000358883

ENST00000374430

ENST00000374431

EntrezGene:1902

g4503456_3p_a_at

GE59467

GE86272

GO:0000187

GO:0000902

GO:0001965

GO:0003674

GO:0004871

GO:0004930

GO:0005515

GO:0005543

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0006464

GO:0007010

GO:0007165

GO:0007186

GO:0007193

GO:0007202

GO:0007204

GO:0007420

GO:0008150

GO:0008219

GO:0008289

GO:0008360

GO:0009986

GO:0010942

GO:0010977

GO:0014003

GO:0016020

GO:0016021

GO:0021549

GO:0021554

GO:0022008

GO:0022038

GO:0022607

GO:0030139

GO:0030154

GO:0030165

GO:0031410

GO:0032060

GO:0035025

GO:0035727

GO:0040011

GO:0042552

GO:0042592

GO:0043005

GO:0043025

GO:0043065

GO:0043123

GO:0043167

GO:0043197

GO:0043198

GO:0043226

GO:0043410

GO:0043951

GO:0048856

GO:0048870

GO:0051482

GO:0051496

GO:0060326

GO:0060999

GO:0070915

GO:0071453

GO:0071673

GO:1904566

HGNC:3166

HPA050667

Hs.75794.0.A3_3p_at

Hs.75794.0.A4_3p_at

ILMN_1674984

ILMN_1701441

IPR000276

IPR002277

IPR004065

IPR017452

LPAR1

LPAR1-201

LPAR1-202

LPAR1-203

MIM:602282

NM_001351402

NM_001351403

NM_001351404

NM_001351405

NM_001351406

NM_001351417

NM_001351419

NM_001351420

NM_001401

NM_057159

NP_001338326

NP_001338327

NP_001338328

NP_001338329

NP_001338330

NP_001338331

NP_001338332

NP_001338333

NP_001338334

NP_001338335

NP_001338336

NP_001338337

NP_001338338

NP_001338339

NP_001338340

NP_001338341

NP_001338342

NP_001338343

NP_001338344

NP_001338345

NP_001338346

NP_001338347

NP_001338348

NP_001338349

NP_001392

NP_476500

PF00001

PH_hs_0027687

PR00237

PR01148

PR01527

Q5VZX0

Q6GPG7

SM01381

U78192

U80811

U80811_at

uc004bfa.4

uc004bfb.4

uc004bfc.4

UPI000011DBF9

XM_005251781

XM_005251782

XM_017014383

XM_017014384

XM_017014385

XM_017014386

XM_017014387

XM_017014388

XM_017014389

XM_017014390

XM_017014391

XM_017014392

XM_017014393

XM_017014394

XM_017014395

XM_017014396

XM_017014397

XM_017014398

XM_017014399

XM_017014400

XM_017014401

XM_017014402

XM_017014403

XM_017014404

XM_017014405

XM_017014406

XM_017014407

XP_005251838

XP_005251839

XP_016869872

XP_016869873

XP_016869874

XP_016869875

XP_016869876

XP_016869877

XP_016869878

XP_016869879

XP_016869880

XP_016869881

XP_016869882

XP_016869883

XP_016869884

XP_016869885

XP_016869886

XP_016869887

XP_016869888

XP_016869889

XP_016869890

XP_016869891

XP_016869892

XP_016869893

XP_016869894

XP_016869895

XP_016869896

Y09479

Participant Of

hasMember

LPAR1,2,3,5 [plasma membrane]

Inferred To

Homologues of LPAR1 [plasma membrane] (Canis familiaris)

Homologues of LPAR1 [plasma membrane] (Danio rerio)

Homologues of LPAR1 [plasma membrane] (Gallus gallus)

Homologues of LPAR1 [plasma membrane] (Sus scrofa)

LPAR1 [plasma membrane] (Bos taurus)

LPAR1 [plasma membrane] (Canis familiaris)

LPAR1 [plasma membrane] (Danio rerio)

LPAR1 [plasma membrane] (Gallus gallus)

LPAR1 [plasma membrane] (Mus musculus)

LPAR1 [plasma membrane] (Rattus norvegicus)

LPAR1 [plasma membrane] (Sus scrofa)

LPAR1 [plasma membrane] (Taeniopygia guttata)

LPAR1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_476500.1, XP_016869874.1, XP_016869875.1, XP_005251838.1, XP_016869876.1, XP_016869878.1, XP_016869890.1, XP_016869877.1, XP_016869891.1, XP_016869879.1, XP_016869894.1, XP_016869895.1, XP_016869892.1, XP_016869893.1, XP_016869896.1, NP_001392.2, XP_016869881.1, XP_016869872.1, XP_016869880.1, XP_016869884.1, XP_016869883.1, XP_016869885.1, XP_016869882.1, XP_016869888.1, XP_016869873.1, XP_016869889.1, XP_016869886.1, XP_016869887.1, XP_005251839.1

ZINC - Metabolites

LPAR1_HUMAN

ZINC - Substances

LPAR1_HUMAN

GeneCards

Q92633

DOCK Blaster

4Z35, 4Z36, 4Z34

ZINC target

Q92633

ZINC - Biogenic

LPAR1_HUMAN

PRO

Q92633

ZINC - Predictions - Purchasable

LPAR1_HUMAN

Orphanet

24681

HMDB Protein

HMDBP02852

PDB

4Z36, 4Z34, 4Z35