Reactome | DNAJA2 [cytosol]

DNAJA2 [cytosol]

Stable Identifier

R-SCE-3371555

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P25491

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Saccharomyces cerevisiae)
    - ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)
      - HSP40:HSP70:ADP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP40:HSP70:ATP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)
    - HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)
      - HSP40:HSP70:ATP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP40:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)
    - STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)
      - HSP40:HSP70:ADP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP40s [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)
        
        DNAJA2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P25491

Reference Genes

BioGPS Gene:855661

ENSEMBL:YNL064C

KEGG:sce:YNL064C

Monarch:855661

NCBI Gene:855661

SGD:YNL064C

UCSC:P25491

Reference Transcript

RefSeq:NM_001182902.1

Other Identifiers

1775968_at

855661

8924_at

GO:0001671

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0006457

GO:0006458

GO:0006511

GO:0006605

GO:0006626

GO:0006970

GO:0007005

GO:0008150

GO:0008270

GO:0009267

GO:0009408

GO:0015031

GO:0015931

GO:0017053

GO:0030433

GO:0030544

GO:0031072

GO:0034605

GO:0035719

GO:0036503

GO:0042026

GO:0042221

GO:0042594

GO:0042787

GO:0043167

GO:0045047

GO:0045892

GO:0046872

GO:0048471

GO:0051082

GO:0051087

GO:0051131

GO:0051169

GO:0051603

GO:0070482

GO:0071470

GO:0072380

Participates

as a member of

Homologues of DNAJA2 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

SOH-C149,C150-DNAJA1 [cytosol]

DNAJA4 [cytosol]

Inferred From

DNAJA2 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

YNL064C_mRNA, YNL064C, YNL064C

PRO

P25491

PDB

1XAO, 1NLT, 5VSO

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06839 RAD3	2	apo-RAD3 [cytosol] (R-SCE-2564780) ERCC2 [nucleoplasm] (R-SCE-67443)	0.643	4
UniProt:Q12118 SGT2	2	SGT2 [cytosol] (R-SCE-9629049) SGT2 [cytosol] (R-SCE-5423595)	0.641	3
UniProt:P02829	11	HSP90AA1 [cytosol] (R-SCE-192864) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477)	0.621	3
UniProt:P89105	1	CTR9 [nucleoplasm] (R-SCE-8866694)	0.564	2
UniProt:Q7LKB1 Q7LKB1			0.544	3
UniProt:P38116	2	MyrG-ARL1 [cytosol] (R-SCE-6813896) MyrG-ARL1 [trans-Golgi network membrane] (R-SCE-6813898)	0.527	2
UniProt:P40850 MKT1			0.527	2
UniProt:P31384 CCR4			0.527	2
UniProt:P14540 ALF			0.527	2
UniProt:P26309	2	CDC20 [nucleoplasm] (R-SCE-174112) CDC20 [cytosol] (R-SCE-141412)	0.527	2
UniProt:P12385 SUP45	4	Erf-1 [cytosol] (R-SCE-141665) SUP45 [cytosol] (R-SCE-6800157) SUP45 [cytosol] (R-SCE-9629948) SUP45 [cytosol] (R-SCE-54433)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	2
UniProt:P08458	1	NRBP1 [nucleoplasm] (R-SCE-376332)	0.527	2
UniProt:Q08273	3	RBX1 [nucleoplasm] (R-SCE-1234142) RNF7 (RBX2) [cytosol] (R-SCE-8863132) RBX1 [cytosol] (R-SCE-180582)	0.527	2
UniProt:P25846 MSH1			0.527	2
UniProt:P53295	2	3OHK21-DRG2 [cytosol] (R-SCE-9629595) DRG2 [cytosol] (R-SCE-9629597)	0.527	2
UniProt:P00549	6	PKM [secretory granule lumen] (R-SCE-6801401) PKM [extracellular region] (R-SCE-6806491) PKM [ficolin-1-rich granule lumen] (R-SCE-6801387) PolyUb-PKM-1 [cytosol] (R-SCE-9861692) PKLR-2 [cytosol] (R-SCE-211388) PKM-2 [cytosol] (R-SCE-450658)	0.527	2
UniProt:P10081	2	EIF4A2 [cytosol] (R-SCE-72575) EIF4A1 [cytosol] (R-SCE-72573)	0.527	3
UniProt:P53599 SSK2			0.527	2
UniProt:P19097 FAS2			0.527	2
UniProt:P23287	2	PPP3CA [cytosol] (R-SCE-201771) PPP3CB [cytosol] (R-SCE-2025869-2)	0.527	2
UniProt:P18759	1	NSF [cytosol] (R-SCE-264471)	0.527	2
UniProt:P15108	6	HSP90AA1 [secretory granule lumen] (R-SCE-6801515-2) HSP90AA1 [extracellular region] (R-SCE-3221946-2) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470-2) HSP90AA1 [plasma membrane] (R-SCE-534996-2) HSP90AA1 [nucleoplasm] (R-SCE-5082401-2) HSP90AA1 [cytosol] (R-SCE-192864-2)	0.527	2
UniProt:P32589	5	SSE1 [nucleoplasm] (R-SCE-5252053) SSE1 [nucleoplasm] (R-SCE-5251998) SSE1 [cytosol] (R-SCE-5251943) SSE1 [cytosol] (R-SCE-5251946) SSE1 [cytosol] (R-SCE-3299412)	0.527	3
UniProt:P10659 METK1			0.527	2
UniProt:P36009 DHR2	1	DHR2 [nucleoplasm] (R-SCE-6790615)	0.527	2
UniProt:Q99247	1	DUF1 [nucleoplasm] (R-SCE-419549)	0.527	2
UniProt:P25294 SIS1			0.527	2
UniProt:P18851	3	STE4 [cytosol] (R-SCE-6814200) STE4 [cytosol] (R-SCE-6814203) STE4 [cytosol] (R-SCE-6814204)	0.527	2
UniProt:P32324 EFT1	11	EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [cytosol] (R-SCE-156901) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) nascent EEF2 [cytosol] (R-SCE-5358472) diphthine EEF2 [cytosol] (R-SCE-5358501) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EFT1 [cytosol] (R-SCE-5367015) Me3K525-EEF2 [cytosol] (R-SCE-8932237)	0.527	4
UniProt:P32641	1	RAD17 [nucleoplasm] (R-SCE-3008665)	0.527	3
UniProt:P10591	17	SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252009-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-5251981-2) SSA1 [cytosol] (R-SCE-3371521-2)	0.527	3
UniProt:P42841	1	PFS2 [nucleoplasm] (R-SCE-8938784)	0.527	2
UniProt:P12753 RAD50	1	DNA repair protein RAD50 [nucleoplasm] (R-SCE-981774)	0.527	2
UniProt:P36046 MIA40	1	MIA40 [mitochondrial intermembrane space] (R-SCE-1252148)	0.527	2
UniProt:P54115	4	ALDH2 [mitochondrial matrix] (R-SCE-71718-3) ALDH1A3 [cytosol] (R-SCE-2980896-3) ALDH1A2 [cytosol] (R-SCE-2980945-3) ALDH1A1 [cytosol] (R-SCE-71688-3)	0.527	2
UniProt:P21672 RIR3			0.527	2
UniProt:P25453 DMC1			0.527	2
UniProt:Q08496 DIA2			0.527	2
UniProt:P22202	17	SSA4 [cytosol] (R-SCE-3371521-5) SSA4 [cytosol] (R-SCE-5251981-5) SSA4 [cytosol] (R-SCE-5251948-5) SSA4 [nucleoplasm] (R-SCE-5252009-5) SSA4 [nucleoplasm] (R-SCE-5252088-5) SSA4 [nucleoplasm] (R-SCE-5252082-5) SSA4 [nucleoplasm] (R-SCE-5082367-5) SSA4 [nucleoplasm] (R-SCE-912480-5) SSA4 [nucleoplasm] (R-SCE-6792605-5) SSA4 [secretory granule lumen] (R-SCE-6801472-5) SSA4 [extracellular region] (R-SCE-6806500-5) SSA4 [extracellular region] (R-SCE-6805872-5) SSA4 [ficolin-1-rich granule lumen] (R-SCE-6801496-5) SSA4 [ficolin-1-rich granule lumen] (R-SCE-6801512-5) SSA4 [cytosol] (R-SCE-6792602-5) SSA4 [cytosol] (R-SCE-3371408-5) SSA4 [cytosol] (R-SCE-3371410-5)	0.527	2
UniProt:P00950 PMG1			0.527	2
UniProt:Q12329 HSP42			0.527	2
UniProt:Q12449 AHA1			0.527	2
UniProt:P23595 PP2A2			0.527	2
UniProt:Q12285 MDY2	1	MDY2 [cytosol] (R-SCE-9629072)	0.524	2
UniProt:P38737 ECM29			0.508	2
UniProt:P33892 GCN1	1	GCN1 [cytosol] (R-SCE-9633502)	0.508	2
UniProt:P04150 NR3C1	3	NR3C1 [nucleoplasm] (R-HSA-879837) NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106)	0.499	5

Cite Us!