Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T183-Prkaa1 [cytosol]
Stable Identifier
R-RNO-9619495
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
p-T183-Ampk-alpha1
Locations in the PathwayBrowser
Expand all
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
ULK complex translocates to the ER (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
ULK1 phosphorylates Beclin-1 (Rattus norvegicus)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK:AMP binds the ULK complex (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
SESN1,2,3 bind AMPK (Rattus norvegicus)
SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MTOR signalling (Rattus norvegicus)
Energy dependent regulation of mTOR by LKB1-AMPK (Rattus norvegicus)
AMPK is dephosphorylated (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
Activation of cytosolic AMPK by phosphorylation (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
Phosphorylated AMPK binds AMP (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)
p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
p-AMPK alpha [cytosol] (Rattus norvegicus)
p-T183-Prkaa1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P54645 Prkaa1
Gene Names
Prkaa1, Ampk1
Chain
chain:1-559
Reference Genes
BioGPS Gene:65248 Prkaa1
KEGG:rno:65248 Prkaa1
Monarch:65248 Prkaa1
NCBI Gene:65248 Prkaa1
UCSC:P54645 Prkaa1
Reference Transcript
RefSeq:NM_019142.4 Prkaa1
Other Identifiers
10813336
1369104_at
1375970_at
17736126
5625918
5736803
5817455
5891119
5978769
6193152
6249209
6263186
6438074
6522655
65248
6586023
6737836
6740939
A_44_P168265
A_44_P212102
GE13688
GE21974
GO:0000045
GO:0000166
GO:0000785
GO:0002181
GO:0002841
GO:0002842
GO:0003013
GO:0003682
GO:0003824
GO:0004672
GO:0004674
GO:0004679
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005815
GO:0005829
GO:0005929
GO:0005975
GO:0006006
GO:0006325
GO:0006338
GO:0006355
GO:0006468
GO:0006629
GO:0006631
GO:0006633
GO:0006646
GO:0006656
GO:0006694
GO:0006695
GO:0006914
GO:0007040
GO:0008202
GO:0008203
GO:0008284
GO:0008610
GO:0009267
GO:0009410
GO:0009411
GO:0009631
GO:0010332
GO:0010508
GO:0010628
GO:0010629
GO:0014823
GO:0016055
GO:0016126
GO:0016301
GO:0016324
GO:0016607
GO:0016740
GO:0017148
GO:0019395
GO:0030163
GO:0030424
GO:0030425
GO:0031000
GO:0031146
GO:0031588
GO:0031648
GO:0031669
GO:0032007
GO:0032991
GO:0033554
GO:0034198
GO:0034599
GO:0036064
GO:0038202
GO:0042149
GO:0042542
GO:0042557
GO:0042593
GO:0042752
GO:0043025
GO:0043066
GO:0043114
GO:0043161
GO:0043226
GO:0043627
GO:0044877
GO:0045722
GO:0045821
GO:0045893
GO:0045947
GO:0045948
GO:0046321
GO:0046326
GO:0046627
GO:0046872
GO:0047322
GO:0048511
GO:0048643
GO:0050821
GO:0050868
GO:0050870
GO:0050995
GO:0055089
GO:0060627
GO:0061462
GO:0061744
GO:0061762
GO:0062028
GO:0065003
GO:0070050
GO:0070301
GO:0070507
GO:0071277
GO:0071333
GO:0071361
GO:0071380
GO:0071456
GO:0071466
GO:0085020
GO:0097009
GO:0106310
GO:0140096
GO:0140823
GO:1900181
GO:1903109
GO:1903829
GO:1903944
GO:1903955
GO:1904179
GO:1904262
GO:1904263
GO:1904428
GO:1905691
GO:1990044
ILMN_1357292
PH_rn_0012139
U40819_at
rc_AI010423_at
Participates
as a component of
p-T183-AMPKalpha1beta1gamma1 [cytosol] (Rattus norvegicus)
as a member of
p-AMPK alpha [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-T183-PRKAA1 [endoplasmic reticulum lumen]
phospho-p-T183-PRKAA1 [nucleoplasm]
Prkaa1 [cytosol]
Inferred From
p-T183-PRKAA1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 183
Coordinate
183
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_062015.2
ENSEMBL
ENSRNOG00000012799
,
ENSRNOP00000017626
,
ENSRNOT00000017626
ZINC target
P54645
PRO
P54645
RGD
3387
PDB
2YA3
,
4QFS
,
6E4U
,
4CFH
,
4F2L
,
4EAJ
,
4QFR
,
4EAI
,
2Y8Q
,
4QFG
,
5T5T
,
4EAL
,
6E4T
,
4EAK
,
2Y8L
,
6E4W
,
2V92
,
5KQ5
,
2V8Q
,
2V9J
,
5UFU
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61589
6
RHOA [endoplasmic reticulum membrane]
(R-RNO-5672082)
RHOA [ficolin-1-rich granule membrane]
(R-RNO-6804971)
RHOA [secretory granule membrane]
(R-RNO-6804980)
RHOA [cytosol]
(R-RNO-194866)
RHOA [cell junction]
(R-RNO-2134503)
RHOA [plasma membrane]
(R-RNO-194510)
0.499
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text