Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-T183-PRKAA1 [cytosol]
Stable Identifier
R-DME-380964
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
O18645
Locations in the PathwayBrowser
Expand all
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
ULK complex translocates to the ER (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
ULK1 phosphorylates ATG13 and RB1CC1 (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
SESN1,2,3 bind AMPK (Drosophila melanogaster)
SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MTOR signalling (Drosophila melanogaster)
Energy dependent regulation of mTOR by LKB1-AMPK (Drosophila melanogaster)
AMPK is dephosphorylated (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
Phosphorylated AMPK binds AMP (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)
p-AMPK heterotrimer:AMP [cytosol] (Drosophila melanogaster)
p-AMPK heterotrimer [cytosol] (Drosophila melanogaster)
p-AMPK alpha [cytosol] (Drosophila melanogaster)
phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O18645
Reference Genes
BioGPS Gene:43904
ENSEMBL:FBgn0023169
FlyBase:FBgn0023169
KEGG:dme:Dmel_CG3051
Monarch:43904
NCBI Gene:43904
UCSC:O18645
Reference Transcript
RefSeq:NM_206604.2
RefSeq:NM_166880.2
RefSeq:NM_057965.4
Other Identifiers
152453_at
1629357_s_at
43904
GO:0000166
GO:0000278
GO:0001558
GO:0003824
GO:0004672
GO:0004674
GO:0004679
GO:0004703
GO:0005524
GO:0005634
GO:0005737
GO:0005768
GO:0006468
GO:0006629
GO:0007163
GO:0008284
GO:0009267
GO:0010508
GO:0016239
GO:0016301
GO:0016740
GO:0030730
GO:0031588
GO:0032007
GO:0042149
GO:0042595
GO:0043050
GO:0044058
GO:0045197
GO:0045792
GO:0048813
GO:0106310
GO:0120025
GO:0140096
GO:1902669
GO:1904262
GO:1904263
GO:1904504
GO:1990044
GO:1990794
GO:2000786
Participates
as a member of
p-AMPK alpha [cytosol] (Drosophila melanogaster)
Other forms of this molecule
PRKAA2 [nucleoplasm]
phospho-p-T172-PRKAA2 [nucleoplasm]
phospho-p-T183-PRKAA1 [nucleoplasm]
PRKAA1 [cytosol]
phospho-p-T172-PRKAA2 [cytosol]
PRKAA2 [cytosol]
Inferred From
p-T183-PRKAA1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 183 (in Homo sapiens)
Coordinate
183
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_996327.1
,
NP_477313.1
,
NP_726730.1
FlyBase
FBgn0023169
PDB
4EAG
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P80386 Prkab1
3
Prkab1 [endoplasmic reticulum lumen]
(R-RNO-9931300)
Prkab1 [nucleoplasm]
(R-RNO-2151199)
Prkab1 [cytosol]
(R-RNO-9619496)
0.591
3
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text