Reactome | AGRN(30-2045) [extracellular region]

AGRN(30-2045) [extracellular region]

Stable Identifier

R-HSA-375056

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

AGRN, Agrin, AGRIN_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00468 AGRN

Gene Names

AGRN, AGRIN

Chain

signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068

Reference Genes

BioGPS Gene:375790 O004686

COSMIC (genes):AGRN AGRN

CTD Gene:375790 O004686

dbSNP Gene:375790 O004686

ENSEMBL:ENSG00000188157 AGRN

HGNC:329 O004686

KEGG:hsa:375790 O004686

Monarch:375790 O004686

NCBI Gene:375790 O004686

OMIM:103320 O004686

UCSC:O00468 O004686

Reference Transcript

Participates

as a component of

as an input of

as a member of

AGRN, HSPG2 [extracellular region] (Homo sapiens)

Other forms of this molecule

HS(4)-AGRN [plasma membrane]

HS(6)-AGRN [plasma membrane]

HS(2)-AGRN [plasma membrane]

HS(1)-AGRN [plasma membrane]

HS(3)-AGRN [plasma membrane]

HS(5)-AGRN [plasma membrane]

AGRN(30-2045) [Golgi lumen]

XylS-AGRN(30-2045) [Golgi lumen]

Gal-Xyl-AGRN [Golgi lumen]

Gal-Gal-Xyl-AGRN [Golgi lumen]

GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]

HS(2)-AGRN [Golgi lumen]

HS(3)-AGRN [Golgi lumen]

HS(1)-AGRN [Golgi lumen]

Heparan(4)-AGRN [Golgi lumen]

Heparan(3)-AGRN [Golgi lumen]

Heparan(2)-AGRN [Golgi lumen]

Heparan(1)-AGRN [Golgi lumen]

Heparan-AGRN [Golgi lumen]

HS(4)-AGRN [Golgi lumen]

HS(5)-AGRN [Golgi lumen]

HS(6)-AGRN [Golgi lumen]

HS(6)-AGRN [lysosomal lumen]

AGRN(30-2045) [lysosomal lumen]

Inferred To

itx-1 [extracellular region] (Caenorhabditis elegans)

AGRN [extracellular region] (Bos taurus)

AGRN [extracellular region] (Canis familiaris)

AGRN [extracellular region] (Sus scrofa)

AGRN(30-2045) [extracellular region] (Caenorhabditis elegans)

AGRN(30-2045) [extracellular region] (Mus musculus)

AGRN(30-2045) [extracellular region] (Rattus norvegicus)

Homologues of AGRN(30-2045) [extracellular region] (Caenorhabditis elegans)

SP2353 [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

XP_005244806.1, NP_940978.2, NP_001292204.1

OpenTargets

ENSG00000188157

ENSEMBL

ENSP00000368678, ENST00000379370, ENSG00000188157

GeneCards

AGRN

HPA

ENSG00000188157-AGRN

PRO

O00468

Pharos - Targets

O00468

GlyGen

O00468

Orphanet

AGRN

PDB

8S9P

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.527	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.527	3
UniProt:P02741 CRP	1	CRP(19-224) [extracellular region] (R-HSA-976719)	0.527	3
UniProt:O15265 ATXN7	2	ATXN7 [nucleoplasm] (R-HSA-8869458) ATXN7 [cytosol] (R-HSA-201591)	0.508	2

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