Reactome | AGRN binds Beta amyloid fibril via GAG chains

AGRN binds Beta amyloid fibril via GAG chains

Stable Identifier

R-HSA-2467665

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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AGRN binds Beta amyloid fibril via GAG chains

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Several agrin (AGRN) ligands require the presence of heparan-sulfate GAG sidechains and probably represent interactions with them. Extracellular ligands include Beta-amyloid (Donahue et al. 1999, Cotman et al. 2000). Other ligands (unconfirmed in humans) include alpha-synuclein fibrils (chicken - Liu et al. 2005), HB-GAM/pleiotropin (Dagget et al. 1996), thrombospondin and FGF2 (Cotman et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10339611	Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma Donahue, JE, Berzin, TM, Rafii, MS, Glass, DJ, Yancopoulos, GD, Fallon, JR, Stopa, EG	Proc. Natl. Acad. Sci. U.S.A.	1999
10673326	Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain Cotman, SL, Halfter, W, Cole, GJ	Mol. Cell. Neurosci.	2000