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Heparan-AGRN [Golgi lumen]
Stable Identifier
R-HSA-2076530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GlcA-Gal-Gal-Xyl-AGRN, Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
BioGPS Gene:375790 O004686
COSMIC (genes):AGRN AGRN
CTD Gene:375790 O004686
dbSNP Gene:375790 O004686
ENSEMBL:ENSG00000188157 AGRN
HGNC:329 O004686
KEGG:hsa:375790 O004686
Monarch:375790 O004686
NCBI Gene:375790 O004686
OMIM:103320 O004686
UCSC:O00468 O004686
Reference Transcript
RefSeq:NM_001305275.1 O004686
RefSeq:NM_198576.3 O004686
RefSeq:XM_005244749.3 O004686
Participates
as a member of
Heparan-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HS(4)-AGRN [plasma membrane]
HS(6)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(1)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(5)-AGRN [plasma membrane]
AGRN(30-2045) [extracellular region]
AGRN(30-2045) [Golgi lumen]
XylS-AGRN(30-2045) [Golgi lumen]
Gal-Xyl-AGRN [Golgi lumen]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
HS(1)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(1)-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(5)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
Inferred To
Heparan-AGRN [Golgi lumen]
(Caenorhabditis elegans)
Heparan-AGRN [Golgi lumen]
(Mus musculus)
Heparan-AGRN [Golgi lumen]
(Rattus norvegicus)
Homologues of Heparan-AGRN [Golgi lumen]
(Caenorhabditis elegans)
SP2353 [Golgi lumen]
(Drosophila melanogaster)
itx-1 [Golgi lumen]
(Caenorhabditis elegans)
AGRN [Golgi lumen]
(Bos taurus)
AGRN [Golgi lumen]
(Canis familiaris)
AGRN [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63645) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
XP_005244806.1
,
NP_940978.2
,
NP_001292204.1
OpenTargets
ENSG00000188157
ENSEMBL
ENSP00000368678
,
ENST00000379370
,
ENSG00000188157
GeneCards
AGRN
HPA
ENSG00000188157-AGRN
PRO
O00468
Pharos - Targets
O00468
GlyGen
O00468
Orphanet
AGRN
PDB
8S9P
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
PDPK1 [plasma membrane]
(R-HSA-61459)
PDPK1 [cytosol]
(R-HSA-202210)
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [nucleoplasm]
(R-HSA-8869458)
ATXN7 [cytosol]
(R-HSA-201591)
0.508
2
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