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AGRN binds Laminins with gamma-1 subunit
Stable Identifier
R-HSA-2396124
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Agrin binds Laminins with gamma-1 subunit
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
AGRN binds Laminins with gamma-1 subunit (Homo sapiens)
General
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Agrin (AGRN) is a large (>400 kDa) multi-domain heparan sulfate proteoglycan found in basement membranes. It is a critical organizer of postsynaptic differentiation at the skeletal neuromuscular junction; synaptogenesis is profoundly disrupted in its absence (Gautam et al. 1996). Two alternate N-termini exist with differential expression, tissue localization and function. The predominant longer LN form (Burgess et al. 2000) starts with a secretion signal sequence and a laminin-binding domain (Denzer et al. 1995, Kammerer et al. 1999); the shorter SN form associates with the plasma membrane (Burgess et al. 2000, Neumann et al. 2001). Following the SN or LN regions are 8 follistatin repeats, known to bind growth factors and inhibit proteases in other proteins. The central region has two repeats homologous to domain III of laminin. The C-terminal portion, which is responsible for the molecule's known signalling functions, contains four EGF repeats and three LG (G) domains homologous to those found in laminin alpha chains, neurexins and slits (Timpl et al. 2000).
The N-terminus of the LN form of AGRN binds to the laminin gamma1 subunit (Denzer et al. 1997, Kammerer et al. 1999, Mascarenhas et al. 2003). This may indirectly bind AGRN to integrins on the cell surface (Bezakova & Ruegg 2003).
Participants
Input
AGRN(30-2045) [extracellular region]
(Homo sapiens)
Laminins with gamma-1 [extracellular region]
(Homo sapiens)
Output
AGRN:Laminins with gamma-1 [extracellular region]
(Homo sapiens)
Participates
as an event of
ECM proteoglycans (Homo sapiens)
Inferred From
AGRN binds laminins (Mus musculus)
Authored
Jupe, S (2013-01-10)
Reviewed
Ricard-Blum, S (2013-05-22)
Venkatesan, N (2013-05-21)
Created
Jupe, S (2012-07-09)
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