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AGRN binds NCAM1, PTPRS
Stable Identifier
R-HSA-2467659
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
AGRN binds NCAM1, PTPRS (Homo sapiens)
General
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Several agrin (AGRN) ligands require the presence of heparan-sulfate sidechains and are probably mediated by them. Membrane-associated AGRN ligands include the neural cell adhesion molecule NCAM1 (Burg et al. 1995, Tsen et al. 1995, Cole & Halfter 1996 - represented in REACT_19071) and receptor protein tyrosine phosphatase sigma (PTPRS) (Aricescu et al. 2002).
Participants
Input
AGRN(30-2068) [extracellular region]
(Homo sapiens)
NCAM1, PTPRS [plasma membrane]
(Homo sapiens)
Output
AGRN:NCAM1, PTPRS [plasma membrane]
(Homo sapiens)
Participates
as an event of
ECM proteoglycans (Homo sapiens)
Inferred From
AGRN binds NCAM1, PTPRS (Gallus gallus)
Authored
Jupe, S (2013-01-10)
Reviewed
Venkatesan, N (2013-05-21)
Ricard-Blum, S (2013-05-22)
Created
Jupe, S (2012-09-13)
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