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Gal-Xyl-AGRN [Golgi lumen]
Stable Identifier
R-HSA-2064130
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective B3GALT6 causes EDSP2 and SEMDJL1 (Homo sapiens)
Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-AGRN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-AGRN [Golgi lumen] (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-AGRN [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-AGRN [Golgi lumen] (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-AGRN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
BioGPS Gene:375790 O004686
COSMIC (genes):AGRN AGRN
CTD Gene:375790 O004686
dbSNP Gene:375790 O004686
ENSEMBL:ENSG00000188157 AGRN
HGNC:329 O004686
KEGG:hsa:375790 O004686
Monarch:375790 O004686
NCBI Gene:375790 O004686
OMIM:103320 O004686
UCSC:O00468 O004686
Reference Transcript
RefSeq:NM_001305275.1 O004686
RefSeq:NM_198576.3 O004686
RefSeq:XM_005244749.3 O004686
Participates
as a member of
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HS(4)-AGRN [plasma membrane]
HS(6)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(1)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(5)-AGRN [plasma membrane]
AGRN(30-2045) [extracellular region]
AGRN(30-2045) [Golgi lumen]
XylS-AGRN(30-2045) [Golgi lumen]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
HS(1)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(1)-AGRN [Golgi lumen]
Heparan-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(5)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
Inferred To
SP2353 [Golgi lumen]
(Drosophila melanogaster)
itx-1 [Golgi lumen]
(Caenorhabditis elegans)
Gal-Xyl-AGRN [Golgi lumen]
(Caenorhabditis elegans)
Gal-Xyl-AGRN [Golgi lumen]
(Mus musculus)
Gal-Xyl-AGRN [Golgi lumen]
(Rattus norvegicus)
Homologues of Gal-Xyl-AGRN [Golgi lumen]
(Caenorhabditis elegans)
AGRN [Golgi lumen]
(Bos taurus)
AGRN [Golgi lumen]
(Canis familiaris)
AGRN [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63502) at unknown position
Modification
beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
XP_005244806.1
,
NP_940978.2
,
NP_001292204.1
OpenTargets
ENSG00000188157
ENSEMBL
ENSP00000368678
,
ENST00000379370
,
ENSG00000188157
GeneCards
AGRN
HPA
ENSG00000188157-AGRN
PRO
O00468
Pharos - Targets
O00468
GlyGen
O00468
Orphanet
AGRN
PDB
8S9P
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
PDPK1 [plasma membrane]
(R-HSA-61459)
PDPK1 [cytosol]
(R-HSA-202210)
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [nucleoplasm]
(R-HSA-8869458)
ATXN7 [cytosol]
(R-HSA-201591)
0.508
2
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