Reactome | CRP(19-224) [extracellular region]

CRP(19-224) [extracellular region]

Stable Identifier

R-HSA-976719

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C-reactive protein, CRP, CRP_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Classical antibody-mediated complement activation (Homo sapiens)
        
        Activation of C1r (Homo sapiens)
        
        C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Homo sapiens)
        
        C-reactive protein pentamer:phosphocholine [plasma membrane] (Homo sapiens)
        
        C-reactive protein homopentamer [extracellular region] (Homo sapiens)
        
        CRP(19-224) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02741 CRP

Gene Names

CRP, PTX1

Chain

signal peptide:1-18, chain:19-224, chain:19-223

Reference Genes

BioGPS Gene:1401 CRP

COSMIC (genes):CRP CRP

CTD Gene:1401 CRP

dbSNP Gene:1401 CRP

ENSEMBL:ENSG00000132693 CRP

ENSEMBL_homo_sapiens_GENE:ENSG00000132693.12 CRP

HGNC:2367 CRP

KEGG Gene (Homo sapiens):1401 CRP

Monarch:1401 CRP

NCBI Gene:1401 CRP

OMIM:123260 CRP

UCSC:P02741 CRP

Reference Transcript

Other Identifiers

11734732_s_at

11744471_s_at

1401

16695151

205753_PM_at

205753_at

2439713

2439715

2439716

2439717

2439718

2439719

2439720

2439721

2439722

2439723

2439724

2439725

2439726

37020_PM_at

37020_at

4901355_3p_at

7921449

A_24_P342484

A_33_P3317670

GE59819

GO:0001849

GO:0002376

GO:0003013

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0006953

GO:0006954

GO:0008228

GO:0010628

GO:0010745

GO:0010888

GO:0016192

GO:0030154

GO:0030169

GO:0032677

GO:0032930

GO:0032945

GO:0033265

GO:0042310

GO:0042802

GO:0045087

GO:0046872

GO:0050750

GO:0050830

GO:0098542

HMNXSV003009852

ILMN_1780575

PH_hs_0004413

TC01003389.hg

X56692_at

g10835134_3p_at

g10835134_3p_x_at

Participates

as a component of

C-reactive protein homopentamer [extracellular region] (Homo sapiens)

Inferred To

CRP(19-224) [extracellular region] (Mus musculus)

CRP(19-224) [extracellular region] (Rattus norvegicus)

CRP [extracellular region] (Bos taurus)

CRP [extracellular region] (Canis familiaris)

CRP [extracellular region] (Gallus gallus)

CRP [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000558.2, NP_001315987.1, NP_001315986.1

OpenTargets

ENSG00000132693

HPA

ENSG00000132693-CRP

GeneCards

P02741

Ensembl

ENST00000255030, ENSP00000255030, ENST00000368112, ENSG00000132693, ENSP00000357093

PRO

P02741

Pharos - Targets

P02741

HMDB Protein

HMDBP02073

PDB

7TBA, 1B09, 7PKE, 7PK9, 1LJ7, 1GNH, 7PKF, 7PKG, 3L2Y, 3PVO, 3PVN, 7PKB, 7PKH, 7PKD

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.976	39
phosphocholine [ChEBI:18132]	3	ChoP [extracellular region] (R-ALL-6814794) ChoP [endoplasmic reticulum lumen] (R-ALL-1606280) ChoP [cytosol] (R-ALL-194358)	0.589	2
UniProt:Q9UBV7 B4GALT7	4	B4GALT7 A186D [Golgi membrane] (R-HSA-3621785) B4GALT7 L206P [Golgi membrane] (R-HSA-3621790) B4GALT7 R270C [Golgi membrane] (R-HSA-3621734) B4GALT7 [Golgi membrane] (R-HSA-1889950)	0.527	2
UniProt:O00468 AGRN	20	AGRN(30-2045) [lysosomal lumen] (R-HSA-2090057) HS(6)-AGRN [lysosomal lumen] (R-HSA-2090081) HS(1)-AGRN [Golgi lumen] (R-HSA-2076350) HS(2)-AGRN [Golgi lumen] (R-HSA-2076521) HS(3)-AGRN [Golgi lumen] (R-HSA-2076493) HS(4)-AGRN [Golgi lumen] (R-HSA-2076337) HS(6)-AGRN [Golgi lumen] (R-HSA-2076568) HS(5)-AGRN [Golgi lumen] (R-HSA-2076606) Heparan-AGRN [Golgi lumen] (R-HSA-2076530) Heparan(1)-AGRN [Golgi lumen] (R-HSA-2076317) Heparan(2)-AGRN [Golgi lumen] (R-HSA-2076301) Heparan(4)-AGRN [Golgi lumen] (R-HSA-2076300) Heparan(3)-AGRN [Golgi lumen] (R-HSA-2076569) AGRN(30-2045) [Golgi lumen] (R-HSA-2054104) XylS-AGRN(30-2045) [Golgi lumen] (R-HSA-2064220) Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064130) HS(4)-AGRN [plasma membrane] (R-HSA-2076654) HS(6)-AGRN [plasma membrane] (R-HSA-2076678) HS(2)-AGRN [plasma membrane] (R-HSA-2076686) HS(1)-AGRN [plasma membrane] (R-HSA-2076634)	0.527	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.454	2

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