Reactome | NR3C1-1 [nucleoplasm]

NR3C1-1 [nucleoplasm]

Stable Identifier

R-HSA-3196163

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Glucocorticoid receptor isoform 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04150-1 NR3C1

Gene Names

NR3C1, GRL

Other Identifiers

1102_s_at

11735194_a_at

11736504_a_at

11741227_a_at

11742190_a_at

11742425_a_at

11743737_a_at

11743738_a_at

11743739_a_at

11751289_a_at

11755240_s_at

17001100

201865_3p_x_at

201865_PM_x_at

201865_x_at

201866_PM_s_at

201866_s_at

211671_PM_s_at

211671_s_at

216321_PM_s_at

216321_s_at

2879322

2879323

2879324

2879325

2879326

2879327

2879336

2879338

2879339

2879342

2879346

2879347

2879366

2879373

2879374

2879375

2879378

2879379

2879380

2879381

2879382

2879383

2879384

2879385

2879386

2879387

2879388

2879390

2879391

2879398

2879399

2879400

2908

36690_at

3672865

706_at

76985_at

8114814

A_23_P214059

A_24_P214754

A_33_P3216297

A_33_P3767927

GE57805

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001046

GO:0001227

GO:0001228

GO:0003677

GO:0003700

GO:0003723

GO:0004879

GO:0004883

GO:0005496

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006111

GO:0006325

GO:0006355

GO:0006357

GO:0006629

GO:0006915

GO:0006954

GO:0007059

GO:0007165

GO:0008211

GO:0008270

GO:0008289

GO:0009611

GO:0010467

GO:0014004

GO:0016020

GO:0016607

GO:0017025

GO:0019901

GO:0022414

GO:0030154

GO:0030325

GO:0030518

GO:0031946

GO:0031958

GO:0032991

GO:0034056

GO:0035249

GO:0042711

GO:0042802

GO:0042921

GO:0043226

GO:0043525

GO:0043565

GO:0045202

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048708

GO:0048856

GO:0051301

GO:0051384

GO:0051414

GO:0051879

GO:0060603

GO:0061744

GO:0071383

GO:0071385

GO:0071549

GO:0071560

GO:0150076

GO:1901654

GO:1902895

GO:1990239

GO:1990837

GO:1990841

HMNXSV003012343

HMNXSV003022467

HMNXSV003032444

Hs.75772.0.S1_3p_a_at

Hs.75772.1.S1_3p_a_at

ILMN_1668525

ILMN_1812384

ILMN_2389347

M10901_at

PH_hs_0026745

PH_hs_0034651

TC05001887.hg

g4504132_3p_a_at

g458656_3p_s_at

Participates

as a member of

NR [nucleoplasm] (Homo sapiens)

Inferred To

nr3c1 [nucleoplasm] (Danio rerio)

nr3c1 [nucleoplasm] (Xenopus tropicalis)

knrl [nucleoplasm] (Drosophila melanogaster)

Nr3c1 [nucleoplasm] (Mus musculus)

Nr3c1 [nucleoplasm] (Rattus norvegicus)

ERR [nucleoplasm] (Drosophila melanogaster)

kni [nucleoplasm] (Drosophila melanogaster)

NR3C1 [nucleoplasm] (Bos taurus)

NR3C1 [nucleoplasm] (Canis familiaris)

NR3C1 [nucleoplasm] (Gallus gallus)

NR3C1 [nucleoplasm] (Sus scrofa)

Homologues of NR3C1-1 [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001191190.1, NP_001191191.1, NP_001018087.1, NP_001018086.1, NP_001019265.1, NP_001351109.1, XP_005268480.1, XP_005268476.1, XP_005268479.1, NP_001018661.1, XP_016864886.1, XP_005268477.1, NP_001191192.1, NP_001191193.1, XP_016864887.1, NP_000167.1, NP_001191189.1, NP_001191187.1, NP_001351114.1, NP_001351113.1, NP_001018085.1, NP_001351110.1, NP_001351112.1, NP_001018084.1, NP_001191188.1, NP_001351111.1

ZINC - World Drugs

GCR_HUMAN

Guide to Pharmacology - Targets

625

OpenTargets

ENSG00000113580

ENSEMBL

ENSP00000343205, ENST00000394466, ENSP00000387672, ENSP00000377979, ENSP00000422518, ENST00000394464, ENST00000415690, ENST00000504572, ENST00000343796, ENST00000231509, ENSP00000377977, ENST00000503201, ENST00000424646, ENSP00000231509, ENSP00000427672, ENSG00000113580, ENSP00000405282

ZINC - FDA approved

GCR_HUMAN

ZINC - Substances

GCR_HUMAN

ZINC - Biogenic

GCR_HUMAN

ZINC target

P04150

PRO

P04150

GlyGen

P04150

PDB

5EMQ, 3K23, 4P6X, 5EMP, 3K22, 4P6W, 7KW7, 4UDD, 5G5W, 3BQD, 5UC1, 5E6B, 5VA0, 5E6C, 6EL6, 5CBZ, 8FFV, 8FFW, 4MDD, 6X6D, 6YOS, 5CBX, 4HN6, 7PRW, 1P93, 7PRV, 5NFT, 1M2Z, 6CFN, 6YMO, 5G3J, 4UDC, 3CLD, 5CC1, 5UC3, 6DXK, 5E6A, 6EL7, 4CSJ, 5E69, 5VA7, 6EL9, 5EMC, 1NHZ, 7KRJ, 5E6D, 3H52, 6X6E, 8VKZ, 5CBY, 5NFP, 4LSJ, 6BQU, 4HN5, 7PRX, 3E7C, 6YO8, 8A9G

ZINC - Investigational

GCR_HUMAN

ZINC - Metabolites

GCR_HUMAN

HPA

ENSG00000113580-NR3C1

GeneCards

NR3C1

Pharos - Targets

P04150

Orphanet

NR3C1

ZINC - Predictions - Purchasable

GCR_HUMAN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.775	8
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.643	4
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.635	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.611	5
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.61	5
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:P25491	3	YDJ1 [cytosol] (R-SCE-9857072) YDJ1 [cytosol] (R-SCE-3371578) YDJ1 [cytosol] (R-SCE-3371555)	0.499	5
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.463	3

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