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6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
Stable Identifier
R-HSA-265073
Type
Complex
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Proinsulin-Zinc-Calcium Complex (granule)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Insulin processing (Homo sapiens)
PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Participants
components
x 6
6xHC-INS(25-110) [secretory granule lumen]
(Homo sapiens)
Ca2+ [secretory granule lumen]
x 2
Zn2+ [secretory granule lumen]
Participates
as an input of
Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)
PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)
as an output of
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)
Inferred To
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
(Canis familiaris)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
(Danio rerio)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
(Gallus gallus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
(Mus musculus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
(Rattus norvegicus)
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