INS(25-110) [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-264893
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Proinsulin
Locations in the PathwayBrowser for interactor UniProt:P01308 INS
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External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
BioGPS Gene:3630 INS
COSMIC - genes:INS INS
CTD Gene:3630 INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
HGNC:6081 INS
KEGG:hsa:3630 INS
Monarch:3630 INS
NCBI Gene:3630 INS
OMIM:176730 INS
UCSC:P01308 INS
Reference Transcript
Participates
as an input of
as an output of
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
C Peptide [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
6xHC-INS(25-110) [Golgi membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
INS(90-110) [endosome lumen]
INS(25-54) [endosome lumen]
2xHC-INS(25-54) [extracellular region]
4xHC-INS(90-110) [extracellular region]
Inferred To
ins [endoplasmic reticulum lumen] (Danio rerio)
Ins1 [endoplasmic reticulum lumen] (Mus musculus)
Ins1 [endoplasmic reticulum lumen] (Rattus norvegicus)
Ins2 [endoplasmic reticulum lumen] (Rattus norvegicus)
Homologues of INS(25-110) [endoplasmic reticulum lumen] (Mus musculus)
Homologues of INS(25-110) [endoplasmic reticulum lumen] (Rattus norvegicus)
INS [endoplasmic reticulum lumen] (Bos taurus)
INS [endoplasmic reticulum lumen] (Canis familiaris)
INS [endoplasmic reticulum lumen] (Gallus gallus)
INS [endoplasmic reticulum lumen] (Sus scrofa)
Ins2(25-110) [endoplasmic reticulum lumen] (Mus musculus)
Cross References
RefSeq
OpenTargets
ENSEMBL
GeneCards
INS
HPA
PRO
Pharos - Targets
Orphanet
INS
PDB
4EYD, 3U4N, 5USV, 5UDP, 4IYD, 1HIT, 1SJT, 5MT3, 5CNY, 3V19, 8ONR, 2N2V, 3V1G, 9LVX, 5UU4, 3HYD, 1ZNJ, 3W80, 5HYJ, 9M50, 2MPG, 5WOB, 4F0N, 3W12, 2M1E, 5E7W, 3EXX, 7Z5L, 5EN9, 3W7Y, 4UNE, 2RN5, 1IOH, 2KQP, 1MSO, 6VES, 3I40, 2WS0, 7STK, 5AIY, 4AKJ, 2VJZ, 7SL4, 2OLY, 2WS7, 4AJZ, 3AIY, 5BOQ, 9LVD, 4EX0, 8GUY, 2K9R, 1G7B, 8ONK, 3KQ6, 5BTS, 8ONP, 3ZQR, 2KXK, 5HPU, 5UU3, 1VKT, 1T1Q, 4F1A, 3W13, 6CEB, 2M1D, 2MLI, 5CO9, 2R35, 2OM1, 4P65, 7BW7, 8WU0, 3E7Y, 1MHJ, 1XGL, 3P33, 7YQ3, 4GBI, 2JZQ, 7QID, 5HQI, 4F4V, 2WRW, 3TT8, 6SOF, 6HN5, 5CJO, 1T1K, 4FG3, 7STH, 4EX1, 6CE7, 4EFX, 7QAC, 4EWW, 4EXX, 8YYS, 4AIY, 5HPR, 1HIS, 5MT9, 7MD4, 1SF1, 1T1P, 4F1B, 5URT, 2WRU, 6H3M, 7PG0, 5UQA, 4F0O, 2WC0, 5VIZ, 8IPZ, 5CO6, 2L1Z, 8PJH, 3ZU1, 7SL2, 4UNG, 1HIQ, 3W7Z, 5C0D, 7STI, 8HSK, 2WS1, 8EYX, 2HIU, 6VEP, 4F51, 3ROV, 4OGA, 8SBD, 4EWX, 4IYF, 6GV0, 9LVC, 3ILG, 4EY9, 1GUJ, 1Q4V, 6JR3, 1G7A, 5USP, 4F1C, 4CXL, 4IUZ, 2JV1, 1EV6, 1HUI, 7MD5, 3JSD, 2HH4, 2WS6, 2OM0, 7Z5Q, 5MHD, 2OMG, 7NMG, 9M4Z, 2CEU, 1A7F, 6GNQ, 3UTQ, 3E7Z, 6U46, 2L1Y, 1TRZ, 7YQ4, 7SL3, 1MHI, 2OMI, 1IOG, 4UNH, 2WS4, 8EYY, 7PG4, 1LPH, 8HGZ, 5MWQ, 2KJU, 5BQQ, 5ENA, 8Z4B, 2KJJ, 1XDA, 4GBN, 4F8F, 4AK0, 4GBK, 4WDI, 4XC4, 1LKQ, 4F1D, 5T7R, 1EV3, 3ZS2, 2C8R, 2G54, 2N2X, 6NWV, 4EYP, 2H67, 7RZF, 2LGB, 1HTV, 9M51, 2QIU, 2OMQ, 2MVD, 7BW8, 1W8P, 8GSG, 6CE9, 2JMN, 1J73, 5EMS, 4Z76, 6B3Q, 4EYN, 2OMH, 2WRX, 4Y1A, 2WBY, 6VER, 6S4J, 1FU2, 7PG2, 1ZEH, 6P4Z, 1BEN, 7KD6, 1AI0, 8RVT, 1TYM, 8VCX, 6JK8, 1JCO, 8VDD, 2JUM, 3Q6E, 6X4X, 1EFE, 8ONI, 2C8Q, 4NIB, 6B70, 2G56, 3FQ9, 7RZE, 2VK0, 1OS4, 1T0C, 4FKA, 6CK2, 1FUB, 8RRP, 8PI4, 7S4Y, 2JUV, 1B9E, 2M2P, 3P2X, 3BXQ, 5MAM, 2R34, 3I3Z, 7SL1, 6O17, 1XW7, 5BPO, 4Z77, 7MQR, 7PG3, 5HRQ, 7QGF, 1TYL, 4GBC, 5USS, 5WBT, 4GBL, 1UZ9, 3UTT, 1SJU, 4CXN, 4CY7, 4F1G, 3ZI3, 7NHU, 4EWZ, 2M2N, 1EVR, 5UU2, 9M4Y, 8PI5, 7V3P, 2HHO, 1QJ0, 5UOZ, 2JUU, 2MVC, 2M2O, 6TC2, 3W11, 5WDM, 6Z7W, 6S34, 2LWZ, 8EZ0, 4Z78, 1JK8, 1RWE, 6S4I, 1QIZ, 7MQO, 4Y19, 1AIY, 6K59, 7SL6, 1ZEG, 7MQS, 2K91, 6TYH, 9LVE, 1KMF, 4AJX, 4RXW, 4EY1, 7JP3, 3IR0, 3UTS, 5CO2, 7U6E, 2N2W, 9LVY, 5URU, 2M2M, 9M4X, 2MPI, 8PI6, 4F4T, 2W44, 3INC, 1K3M, 7BWA, 1OS3, 7RZI, 8OKY, 6BFC, 6Z7Y, 1JCA, 2R36, 4F1F, 1HLS, 2KQQ, 7YQ5, 6VET, 7RKD, 1QIY, 8HSF, 7SL7, 2OLZ, 2AIY, 2WRV, 7STJ
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01308 INS  20 0.971 21
 UniProt:P06213-2 INSR      0.697 6
 UniProt:P14735-1 IDE      0.618 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:Q8IUG1 KRTAP1-3  1 0.556 3
 UniProt:Q07627 KRTAP1-1  1 0.556 3
 UniProt:A8MQ03 CRTP1      0.556 3
 UniProt:P0DPK4 NOTCH2NLC  1 0.556 3
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