MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein

Stable Identifier
R-HSA-211289
Type
Reaction [omitted]
Species
Homo sapiens
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The INS1 gene, encoding insulin precursor protein, is transcribed and its mRNA is translated on membrane-associated ribosomes. INS1 transcription is positively regulated by the activities of the MAFA, NKX2-2, PAX6, and PDX1 transcription factors. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.

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Summation

RFX6 binds an X box motif in the promoter of the insulin (INS) gene and transactivates transcription (Chandra et al. 2014). RFX6 also activates expression of genes encoding calcium channels. Missense mutations in RFX6 appear to cause neonatal diabetes.

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