Tie2 Signaling

Stable Identifier
R-HSA-210993
Type
Pathway
Species
Homo sapiens
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The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.

Literature References
PubMed ID Title Journal Year
11191051 Tek/Tie2 signaling: new and old partners

Dumont, DJ, Jones, N

Cancer Metastasis Rev 2000
9764820 The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

Dumont, DJ, Jones, N

Oncogene 1998
11969368 The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development

Ward, NL, Dumont, DJ

Semin Cell Dev Biol 2002
11566266 Angiopoietin and Tie signaling pathways in vascular development

Sato, TN, Loughna, S

Matrix Biol 2001
Participants
Participates
Orthologous Events
Cross References
GlyCosmos
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