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Interaction of SOS-1 to Tie2 bound Grb2
Stable Identifier
R-HSA-210974
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Interaction of SOS-1 to Tie2 bound Grb2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Grb2 binds directly to autophosphorylated Tie2 receptor. GRB2 also contains two SH3 domains, which bring various ligands to the sites of active signaling. One of the SH3 domains on Tie2-bound Grb2 recruits SOS1, an activating nucleotide exchange factor for Ras. This interaction of Sos1 to Grb2 brings Sos1 towards Ras molecules leading to Ras activation. Ras is implicated in the MAP kinase cascade, a pathway in cell growth stimulation, migration and differentiation.
Literature References
PubMed ID
Title
Journal
Year
11191051
Tek/Tie2 signaling: new and old partners
Dumont, DJ
,
Jones, N
Cancer Metastasis Rev
2000
7478529
GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase
Peters, KG
,
Turck, CW
,
Huang, L
,
Rao, P
Oncogene
1995
Participants
Input
Grb2 bound to Tie2 [plasma membrane]
(Homo sapiens)
SOS1 [cytosol]
(Homo sapiens)
Output
SOS-1 bound to Tie2:Grb2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Tie2 Signaling (Homo sapiens)
Orthologous Events
Interaction of SOS-1 to Tie2 bound Grb2 (Bos taurus)
Interaction of SOS-1 to Tie2 bound Grb2 (Canis familiaris)
Interaction of SOS-1 to Tie2 bound Grb2 (Danio rerio)
Interaction of SOS-1 to Tie2 bound Grb2 (Gallus gallus)
Interaction of SOS-1 to Tie2 bound Grb2 (Mus musculus)
Interaction of SOS-1 to Tie2 bound Grb2 (Rattus norvegicus)
Interaction of SOS-1 to Tie2 bound Grb2 (Sus scrofa)
Interaction of SOS-1 to Tie2 bound Grb2 (Xenopus tropicalis)
Authored
Garapati, P V (2008-03-05)
de Bono, B (2008-03-05)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2008-01-18)
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