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Interaction of Tie2 with Ang2
Stable Identifier
R-HSA-204863
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Interaction of Tie2 with Ang2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The major ligands for Tie2 are Ang1 and Ang2. Ang1 has been considered as the primary activating ligand of Tie2 whereas role of Ang2 remains controversial. Ang2 acts as stimulating in some studies and inhibiting in others. The activity of Ang2 is concentration dependent. Ang2 possesses similar receptor affinity to Ang1 and they both share the same binding site on Tie2. The Ang2 fibrinogen domain is solely responsible for receptor recognition and binding, the coiled-coil motif mediates its oligomerization.
Literature References
PubMed ID
Title
Journal
Year
16895971
Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
Nguyen, VP
,
Bogdanovic, E
,
Dumont, DJ
J Cell Sci
2006
15893672
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition
Tzvetkova, D
,
Nikolov, DB
,
Barton, WA
Structure
2005
Participants
Input
ANGPT2 [extracellular region]
(Homo sapiens)
TEK [plasma membrane]
(Homo sapiens)
Output
ANGPT2:TEK [plasma membrane]
(Homo sapiens)
Participates
as an event of
Tie2 Signaling (Homo sapiens)
Orthologous Events
Interaction of Tie2 with Ang2 (Bos taurus)
Interaction of Tie2 with Ang2 (Canis familiaris)
Interaction of Tie2 with Ang2 (Danio rerio)
Interaction of Tie2 with Ang2 (Gallus gallus)
Interaction of Tie2 with Ang2 (Mus musculus)
Interaction of Tie2 with Ang2 (Rattus norvegicus)
Interaction of Tie2 with Ang2 (Sus scrofa)
Interaction of Tie2 with Ang2 (Xenopus tropicalis)
Authored
Garapati, P V (2008-03-05)
de Bono, B (2008-03-05)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-12-03)
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